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Effects of anesthetics on coronary microcirculation in post-ischemic heart

Research Project

Project/Area Number 15390477
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Anesthesiology/Resuscitation studies
Research InstitutionSapporo Medical University

Principal Investigator

KANAYA Noriaki  Sapporo Medical University, School of Medicine, Anesthesiology, Associate Professor, 医学部, 講師 (10244344)

Co-Investigator(Kenkyū-buntansha) NAKAYAMA Masayasu  Sapporo Medical University, School of Medicine, Anesthesiology, Assistant Professor, 医学部, 講師 (60336401)
KAWAMATA Mikito  Sapporo Medical University, School of Medicine, Assistant Professor, 医学部, 講師 (90315523)
Project Period (FY) 2003 – 2006
Project Status Completed (Fiscal Year 2006)
Budget Amount *help
¥14,800,000 (Direct Cost: ¥14,800,000)
Fiscal Year 2006: ¥1,100,000 (Direct Cost: ¥1,100,000)
Fiscal Year 2005: ¥1,200,000 (Direct Cost: ¥1,200,000)
Fiscal Year 2004: ¥1,100,000 (Direct Cost: ¥1,100,000)
Fiscal Year 2003: ¥11,400,000 (Direct Cost: ¥11,400,000)
KeywordsHeart / Remodeling / Myocardial Ischemia / Anesthetics
Research Abstract

Anesthetics are known to modulate coronary circulation. However, it is not well known the effects of anesthetics on coronary microcirculation in post-ischemic remodeling heart. We investigated the effects of anesthetics on coronary microcirculation in post-ischemic remodeling rat hearts. Coronary microcirculation was observed by high-resolution CCD camera under pentobarbital anesthesia.

Report

(5 results)
  • 2006 Annual Research Report   Final Research Report Summary
  • 2005 Annual Research Report
  • 2004 Annual Research Report
  • 2003 Annual Research Report
  • Research Products

    (35 results)

All 2007 2006 2005 2004 Other

All Journal Article (25 results) Book (3 results) Publications (7 results)

  • [Journal Article] Propofol increases pulmonary vascular resistance during alpha-adrenoreceptor activation in normal and monocrotaline-induced pulmonary hypertensive rats.2007

    • Author(s)
      Edanaga M, Nakayama M, Kanaya N, Tohse N, Namiki A
    • Journal Title

      Anesth Analg 104・1

      Pages: 112-118

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] 抗生物質投与によるビタミンK欠乏に起因すると思われる凝固抑制で硬膜外血腫を来した1症例.2007

    • Author(s)
      平田直之, 金谷憲明, 渡辺政徳, 清水斎, 並木昭義
    • Journal Title

      麻酔 56・1

      Pages: 181-185

    • NAID

      40015292209

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Propofol increases pulmonary vascular resistance during alpha-adrenoreceptor activation in normal and monocrotaline-induced pulmonary hypertensive rats.2007

    • Author(s)
      Edanaga M, Nakayama M, Kanaya N, Tohse N, Namiki A
    • Journal Title

      Anesth Analg 104

      Pages: 112-118

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Propofol increases pulmonary vascular resistance during alpha-adrenoreceptor activation in normal and monocrotaline-induced pulmonary hypertensive rats.2007

    • Author(s)
      Edanaga M, Nakayama M, Kanaya N, Tohse N, Namiki A.
    • Journal Title

      Anesth Analg 104・1

      Pages: 112-118

    • Related Report
      2006 Annual Research Report
  • [Journal Article] 抗生物質投与によるビタミンK欠乏に起因すると思われる凝固抑制で硬膜外血腫を来した1症例.2007

    • Author(s)
      平田直之, 金谷憲明, 渡辺政徳, 清水斎, 並木昭義.
    • Journal Title

      麻酔 56・1

      Pages: 181-185

    • NAID

      40015292209

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Effects of L-type Ca2+ channel modulation on direct myocardial effects of diazepam and midazolam in adult rat ventricular myocytes.2006

    • Author(s)
      Kanaya N, Murray PA, Damron DS
    • Journal Title

      Journal of Anesthesia 20・1

      Pages: 17-25

    • NAID

      10017245084

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Effects of ulinastatin on pulmonary artery pressure during abdominal aortic aneurysmectomy.2006

    • Author(s)
      Kurosawa S, Kanaya N, Fujimura N, Nakayama M, Edanaga M, Mizuno E, Park KW, Namiki A
    • Journal Title

      J Clin Anesth 18・1

      Pages: 18-23

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Effects of thiopental on bispectral index and heart rate variability.2006

    • Author(s)
      Tsuchiya S, Kanaya N, Hirata N, Kurosawa S, Edanaga, T, Nakayama M, Omote K, Namiki A
    • Journal Title

      Eur J Anaesth 23・6

      Pages: 454-459

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] 術前の経食道心エコーで診断された乳頭筋断裂の1症例.2006

    • Author(s)
      木村慶信, 中山雅康, 鎌佃康宏, 佐藤順一, 金谷憲明, 並木昭義
    • Journal Title

      麻酔 55・10

      Pages: 1247-1249

    • NAID

      40015125951

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Effects of L-type Ca2+ channel modulation on direct myocardial effects of diazepam and midazolam in adult rat ventricular myocytes.2006

    • Author(s)
      Kanaya N, Murray PA, Damron DS
    • Journal Title

      Journal of Anesthesia 20

      Pages: 17-25

    • NAID

      10017245084

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Effects of ulinastatin on pulmonary artery pressure during abdominal aortic aneurysmectomy.2006

    • Author(s)
      Kurosawa S, Kanaya N, Fujimura N, Nakayama M, Edanaga M, Mizuno E, Park KW, Namiki A
    • Journal Title

      J Clin Anesth 18

      Pages: 18-23

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Effects of thiopental on bispectral index and heart rate variability.2006

    • Author(s)
      Tsuchiya S, Kanaya N, Hirata N, Kurosawa S, Edanaga, T, Nakayama M, Omote K, Namiki A
    • Journal Title

      Eur J Anaesth 23

      Pages: 454-459

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Effects of L-type Ca2^+ channel modulation on direct myocardial effects of diazepam and midazolam in adult rat ventricular myocytes.2006

    • Author(s)
      Kanaya N, Murray PA, Damron DS
    • Journal Title

      Journal of Anesthesia 20・1

      Pages: 17-25

    • NAID

      10017245084

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Effects of ulinastatinonpulmonaryarterypressureduringabdominalaortic aneurysmectomy.2006

    • Author(s)
      Kurosawa S, Kanaya N, Fujimura N, Nakayama M, Edanaga M, Mizuno E, Park KW, Namiki A.
    • Journal Title

      J Clin Anesth 18・1

      Pages: 18-23

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Effects of thiopental on bispectral index and heart rate variability.2006

    • Author(s)
      Tsuchiya S, Kanaya N, Hirata N, Kurosawa S, Edanaga T, Nakayama M, Omote K, Namiki A.
    • Journal Title

      Eur J Anaesth 23・6

      Pages: 454-459

    • Related Report
      2006 Annual Research Report
  • [Journal Article] 術前の経食道心エコーで診断された乳頭筋断裂の1症例.2006

    • Author(s)
      木村慶信, 中山雅康, 鎌田康宏, 佐藤順一, 金谷憲明, 並木昭義.
    • Journal Title

      麻酔 55・10

      Pages: 1247-1249

    • NAID

      40015125951

    • Related Report
      2006 Annual Research Report
  • [Journal Article] A useful method for laryngeal mask insertion.2005

    • Author(s)
      Kanaya N, Kanaya J, Namiki A
    • Journal Title

      Journal of Anesthesia 19・5

      Pages: 266-267

    • NAID

      10016650673

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Experimental conditions are important determinants of cardiac inotropic effects of propofol.2005

    • Author(s)
      Kanaya N, Gable B, Wickley PJ, Murray PA, Damron DS
    • Journal Title

      Anesthesiology 103・5

      Pages: 1026-1034

    • Related Report
      2005 Annual Research Report
  • [Journal Article] 新しい気道確保器具(エアウェイ)(CobraPLA)とラリンジアルマスクの比較2005

    • Author(s)
      金谷憲明, 数井 薫, 清水恵子, 紅露伸司, 中山雅康, 並木昭義
    • Journal Title

      臨床麻酔 29・3

      Pages: 569-572

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Forehead is as sensitive as finger pulse oximetry during general anesthesia.2004

    • Author(s)
      Sugino S, Kanaya N, Mizuuchi M, Nakayama M, Namiki A
    • Journal Title

      Can J Anesth 51・5

      Pages: 432-436

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Differential pressor response to intravenous ephedrine during recovery from deliberate hypotension.2004

    • Author(s)
      Kanaya N, Nakayama Y, Nakayama M, Okazaki K, Hattori J, Kurosawa S, Edanaga M, Namiki A
    • Journal Title

      J Clin Anesth 16・4

      Pages: 266-270

    • Related Report
      2004 Annual Research Report
  • [Journal Article] A comparison of the failure times of pulse oximeters during blood pressure cuff-induced hypoperfusion in volunteers.2004

    • Author(s)
      Kawagishi T, Kanaya N, Nakayama M, Kurosawa S Namiki A
    • Journal Title

      Anesth Analg 99・3

      Pages: 793-796

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Left ventricular mechanical performance in elderly patients after induction of anaesthesia. A comparison of inhalational induction with sevoflurane and intravenous induction with fentanyl and propofol.2004

    • Author(s)
      Nishikawa K, Kanaya N, Kawamata M, Namiki A
    • Journal Title

      Anaesthesia 59・10

      Pages: 948-953

    • Related Report
      2004 Annual Research Report
  • [Journal Article] パーカー気管チューブ(Parker Flex-Tip)を用いての巨大声帯ポリープ患者の麻酔経験2004

    • Author(s)
      水野絵里, 金谷憲明, 並木昭義
    • Journal Title

      麻酔 53・7

      Pages: 788-790

    • NAID

      40006340087

    • Related Report
      2004 Annual Research Report
  • [Journal Article] 吸引カテーテルの潤滑性の検討2004

    • Author(s)
      羽生朗子, 鳥谷部政樹, 黒沢さおり, 須佐泰之, 中山雅康, 金谷憲明, 渡辺廣昭, 並木昭義
    • Journal Title

      麻酔 53・9

      Pages: 998-1002

    • Related Report
      2004 Annual Research Report
  • [Book] ここがポイント.麻酔手技上達のコツ.2006

    • Author(s)
      平田直之, 金谷憲明
    • Total Pages
      389
    • Publisher
      南江堂
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Annual Research Report 2006 Final Research Report Summary
  • [Book] 先端医療シリーズ33.麻酔科の新しい流れ.2005

    • Author(s)
      金谷憲明
    • Total Pages
      420
    • Publisher
      先端医療技術研究所
    • Related Report
      2005 Annual Research Report
  • [Book] 役に立つ手術室ハンドブック-手術患者に最良の医療を提供するために-(並木昭義, 渡辺廣昭 編)2004

    • Author(s)
      金谷憲明
    • Related Report
      2004 Annual Research Report
  • [Publications] Kanaya N, Hirata N, Nakayama M, Kurosawa S, Namiki A: "Differential effects of propofol and sevoflurane on heart rate variability"Anesthesiology. 98・1. 34-40 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Hattori J, Fujimura N, Kanaya N, Okazaki K, Namiki A: "Bronchospasm induced by propofol in a patient with sick house syndrome"Anesth Analg. 96・1. 163-164 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Nakayama M, Kanaya N, Ichinose H, Yamamoto S, Namiki A: "Intravenous droperidol causes a reduction in the bispectral index in propofol-sedated patients during spinal anesthesia"Anesth Analg. 96・3. 765-768 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Okazaki K, Seki S, Kanaya N, Hattori J, Tohse N, Namiki A: "Role of endothelium-derived hyperpolarizing factor in phenylephrine-induced oscillatory vasomotion in rat small mesenteric artery"Anesthesiology. 98・5. 1164-1171 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Kurosawa S, Kanaya N, Niiyama Y, Nakayama M, Fujita S, Namiki A: "Landiolol, esmolol and propranolol protect from ischemial reperfusion injury in isolated guinea pig hearts"Can J Anesth. 50・5. 489-494 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Kanaya N, Gable B, Murray PA, Damron DS: "Propofol increases phosphorylation of troponin I and myosin light chain 2 via PKG activation in cardiomyocytes"Anesthesiology. 98・6. 1363-1371 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] 金谷憲明: "麻酔・周術期管理に役立つ臨床モニター機器の知識と使い方"真興交易株式会社図書出版部. 192 (2003)

    • Related Report
      2003 Annual Research Report

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Published: 2003-04-01   Modified: 2016-04-21  

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