Investigation for brain mechanisms of tinnitus using positron emission tomography(PET).
| Project/Area Number |
15390518
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Otorhinolaryngology
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| Research Institution | Osaka University |
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Principal Investigator |
KUBO Takeshi Osaka University, Graduate School of Medicine, Professor, 医学系研究科, 教授 (30107031)
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| Co-Investigator(Kenkyū-buntansha) |
NISHIMURA Hiroshi Osaka University, Graduate School of Medicine, Assistant Professor, 医学系研究科, 助手 (80362698)
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| Project Period (FY) |
2003 – 2004
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| Project Status |
Completed (Fiscal Year 2004)
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| Budget Amount *help |
¥4,500,000 (Direct Cost: ¥4,500,000)
Fiscal Year 2004: ¥1,900,000 (Direct Cost: ¥1,900,000)
Fiscal Year 2003: ¥2,600,000 (Direct Cost: ¥2,600,000)
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| Keywords | Cochlear implant / tinnitus / PET / H_2O_<15> / residual inhibition / ^<11>C-flumazenil / 盲聾患者 |
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| Research Abstract |
Residual inhibition is a transient suppression of tinnitus after auditory stimulation has stopped. We used positron emission tomography to study brain regions underlying residual inhibition in three tinnitus patients with cochlear implants and six normal hearing controls. Regional cerebral blood flow was measured and compared under two conditions : with tinnitus and during the residual inhibition of tinnitus. The right anterior middle and superior temporal gyri (Brodmann areas 21 and 38) were activated during residual inhibition, while the right cerebellum was activated during tinnitus perception in the tinnitus patients. No significant activation was observed in the normal controls. Our results suggest that tinnitus and residual inhibition are related to cortical networks of auditory higher-order processing, memory and attention.
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Report
(3 results)
Research Products
(6 results)
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[Journal Article] Neural mechanism of residual inhibition of tinnitus in cochlear implant users.2005
Author(s)
Y Osaki, H Nishimura, M Takasawa, M Imaizumi, Takayuki Kawashima, Takako Iwaki, N Oku, K Hashikawa, K Doi, T Nishimura, J Hatazawa, T Kubo.
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Journal Title
NeuroReport 16
Pages: 1625-1628
Description
「研究成果報告書概要(和文)」より
Related Report
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[Journal Article] Neural mechanism of residual inhibition of tinnitus in cochlear implant users.2005
Author(s)
Y Osaki, H Nishimura, M Takasawa, M Imaizumi, T Kawashima, T Iwaki, N Oku, K Hashikawa, K Doi, T Nishimura, J Hatazawa, T Kubo.
-
Journal Title
NeuroReport 16
Pages: 1625-1628
Description
「研究成果報告書概要(欧文)」より
Related Report
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