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Improvement of biocompatibility of metallic biomaterials by surface amorphization

Research Project

Project/Area Number 15390581
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field 補綴理工系歯学
Research InstitutionHokkaido Univerisity

Principal Investigator

UO Motohiro  Hokkaido University, Graduate School of DentalMedicine, Associate Professor, 大学院・歯学研究科, 助教授 (20242042)

Co-Investigator(Kenkyū-buntansha) YOKOYAMA Atsuro  Hokkaido University, Graduate School of DentalMedicine, Professor, 大学院・歯学研究科, 教授 (20210627)
WATARI Fumio  Hokkaido University, Graduate School of DentalMedicine, Professor, 大学院・歯学研究科, 教授 (70158682)
Project Period (FY) 2003 – 2005
Project Status Completed (Fiscal Year 2005)
Budget Amount *help
¥14,200,000 (Direct Cost: ¥14,200,000)
Fiscal Year 2005: ¥2,400,000 (Direct Cost: ¥2,400,000)
Fiscal Year 2004: ¥1,700,000 (Direct Cost: ¥1,700,000)
Fiscal Year 2003: ¥10,100,000 (Direct Cost: ¥10,100,000)
Keywordsrarely conteined element / biocompatibility / titanium / X-ray absorption fine structure (XAFS) / metal / nitrization / セレン / レーザー急冷法 / 非晶質 / X線回析
Research Abstract

The biocompatibility is strongly affected by the physical and chemical properties of materials' surfaces. Metal carbides and nitrides are chemically stable compared to their original metals. Then, their biocompatibility are also same as or better than their original metals.
Recently, high energy lasers are applied to the welding of metallic dental restoratives. The laser provides high energy into restricted area without contermination. The authors applied the dental laser welder for surface treatment of dental alloys. Various dental alloys are irradiated by laser with various atmosphere and laser power and their surface properties were estimated. The alloy phase and crystal stracture was changed by laser irradiation. Therefore, the laser heating was possible to provide the heat treatment effect in the restricted area. The laser radiation in the N2 atmosphere, nitride layer was formed on titanium surface and surface hardness was imporoved. Thus, the surface treatment of aimed area was possible by laser irradiation.
To evaluate the biocompatibility, X-ray absorption fine structure (XAFS) analysis was applied for the analysis of titanium (Ti) in the human oral mucosa in contact with Ti dental implants from two different patients. Metallic Ti and an oxide (anatase) were detected. The metallic Ti was distributed in particulate form, which would be debris formed by the abrasion during the operation of implantation. The derivation of titanium oxides were assumed that the dissolved titanium was oxidized in the tissue and titanium dioxide was formed. The possibility of using XAFS for the analysis of the chemical state of rarely contained elements in biological tissue was suggested.

Report

(4 results)
  • 2005 Annual Research Report   Final Research Report Summary
  • 2004 Annual Research Report
  • 2003 Annual Research Report
  • Research Products

    (36 results)

All 2006 2005 2004 2003 Other

All Journal Article (31 results) Publications (5 results)

  • [Journal Article] Selenium distribution in human soft tissue determined by using X-ray scanning analytical microscope and X-ray absorption fine structure analysis2006

    • Author(s)
      Uo M., Asakura K., Kohgo T., Watari F.
    • Journal Title

      Chemistry Letters 35

      Pages: 66-67

    • NAID

      10016907840

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Annual Research Report 2005 Final Research Report Summary
  • [Journal Article] Rare earth oxide containing fluorescent glass filler for composite resin2005

    • Author(s)
      Uo M., Okamoto M., Watari F., Tani K., Morita M., Shintani A.
    • Journal Title

      Dental Materials Journal 24

      Pages: 49-52

    • NAID

      110002983792

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Annual Research Report 2005 Final Research Report Summary
  • [Journal Article] Analysis of Titanium Dental Implants Surrounding Soft Tissue using X-ray Absorption Fine Structure (XAFS)2005

    • Author(s)
      Uo M., Asakura K., Yokoyama A., Totsuka Y., Akasaka T., Watari F.
    • Journal Title

      Chemistry Letters 34

      Pages: 776-777

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Annual Research Report 2005 Final Research Report Summary
  • [Journal Article] The cytotoxicity of metal encapsulating carbon nanocapsules2005

    • Author(s)
      Uo M., Sato Y., Yokoyama A., Watari F., Totsuka Y., Tohji K., et al.
    • Journal Title

      Small 1

      Pages: 816-819

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Biological behavior of hat-stacked carbon nanofibers in the subcutaneous tissue in rats2005

    • Author(s)
      Yokoyama A., Sato Y., Akasaka T., Uo M., Watari F., Tohji K., et al.
    • Journal Title

      Nanoletters 5

      Pages: 157-161

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Influence of length on cytotoxicity of multi-walled carbon nanotubes against human acute monocytic leukemia cell line THP-1 in vitro and subcutaneous tissue of rats in vivo2005

    • Author(s)
      Sato K., Yokoyama A., Akasaka T., Uo M., Watari F., Tohji K., et al.
    • Journal Title

      Molecular Biosystems 1

      Pages: 176-182

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Analysis of Titanium Dental Implants Surrounding Soft Tissue using X-ray Absorption Fine Structure (XAFS)2005

    • Author(s)
      Uo M., Asakura K., Yokoyama A., Tamura K., Totsuka Y., Akasaka T., Watari F.
    • Journal Title

      Chemistry Letters 34

      Pages: 776-777

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] The cytotoxicity of metal encapsulating carbon nanocapsules2005

    • Author(s)
      Uo M., Tamura K, Sato Y., Yokoyama A., Watari F., Totsuka Y., Tohji K.
    • Journal Title

      Small 1

      Pages: 816-819

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Biological behavior of hat-stacked carbon nanofibers in the subcutaneous tissue in rats2005

    • Author(s)
      Yokoyama A., Sato Y., Nodasaka Y., Yamamoto S., Kawasaki T., Shindoh M., Kohgo T., Akasaka T., Uo M., Watari F., Tohji K.
    • Journal Title

      Nanoletters 5

      Pages: 157-161

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Influence of length on cytotoxicity of multi-walled carbon nanotubes against human acute monocytic leukemia cell line THP-1 in vitro and subcutaneous tissue of rats in vivo2005

    • Author(s)
      Sato K., Yokoyama A., Shibata K., Akimoto Y., Ogino S., Nodasaka Y., Kohgo T., Tamura K., Akasaka T., Uo M., Motomiya K., Jayadevan B., Ishiguro M., Hatakeyama R., Watari F., Tohji K.
    • Journal Title

      Molecular Biosystems 1

      Pages: 176-182

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] The cytotoxicity of metal encapsulating carbon nanocapsules2005

    • Author(s)
      Uo M., Sato Y., Yokoyama A., Watari F., Totsuka Y., Tohji K.et al.
    • Journal Title

      Small 1

      Pages: 816-819

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Biological behavior of hat-stacked carbon nanofibers in the subcutaneous tissue in rats2005

    • Author(s)
      Yokoyama A., Sato Y., Akasaka T., Uo M., Watari F., Tohji K.et al.
    • Journal Title

      Nanoletters 5

      Pages: 157-161

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Influence of length on cytotoxicity of multi-walled carbon nanotubes against human acute monocytic leukemia cell line THP-1 in vitro and subcutaneous tissue of rats in vivo2005

    • Author(s)
      Sato K., Yokoyama A., Akasaka T., Uo M., Watari F., Tohji K et al.
    • Journal Title

      Molecular Biosystems 1

      Pages: 176-182

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Rapid analysis of dental metallic restoratives using X-ray Scanning Analytical Microscope2004

    • Author(s)
      Uo M., Watari F.
    • Journal Title

      Dental Materials 20

      Pages: 611-615

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary 2004 Annual Research Report
  • [Journal Article] Quantitative analysis of biological specimens by X-ray scanning analytical microscope2004

    • Author(s)
      Uo M., Tanaka M., Watari F.
    • Journal Title

      Journal of Biomedical Materials Research,PartB Applied Biomaterials 70B

      Pages: 146-151

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Laser welding of titanium and dental precious alloys2004

    • Author(s)
      Iwasaki K., Ohkawa S., Uo M., Akasaka T., Watari F.
    • Journal Title

      Materials Transactions 45

      Pages: 1140-4416

    • NAID

      10012905756

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary 2004 Annual Research Report
  • [Journal Article] Three-dimensional topographic scanning electron microscope and Raman spectroscopic analyses of the irradiation effect on teeth by Nd : YAG, Er : YAG,and CO : lasers2004

    • Author(s)
      Yamada M.K., Uo M., Ohkawa S., Akasaka T., Watari F.
    • Journal Title

      Journal of Biomedical Materials Research,PartB Applied Biomaterials 71B

      Pages: 7-15

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Microparticle formation and its mechanism in single and double emulsion solvent evaporation2004

    • Author(s)
      Rosca I.D., Watari F., Uo M.
    • Journal Title

      Journal of Controlled Release 99

      Pages: 271-280

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary 2004 Annual Research Report
  • [Journal Article] Effects of micro/nano particle size on cell function and morphology2004

    • Author(s)
      Tamura K., Takashi N., Akasaka T., Uo M., Totsuka Y., Watari F.
    • Journal Title

      Key Engineering Materials 254-256

      Pages: 919-922

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary 2004 Annual Research Report
  • [Journal Article] Quantitative analysis of biological specimens by X-ray scanning analytical micro scope2004

    • Author(s)
      Uo M., Tanaka M., Watari F.
    • Journal Title

      Journal of Biomedical Materials Research, Part B Applied Biomaterials 70B

      Pages: 146-151

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Three-dimensional topographic scanning electron microscope and Raman spectroscopic analyses of the irradiation effect on teeth by Nd:YAG, Er:YAG, and CO_2 lasers2004

    • Author(s)
      Yamada M.K., Uo M., Ohkawa S., Akasaka T., Watari F.
    • Journal Title

      Journal of Biomedical Materials Research, Part B-Applied Biomaterials 71B

      Pages: 7-15

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Effects of micro/nano particle size on cell function and morphology2004

    • Author(s)
      Tamura K., Takashi N., Akasaka T., Rosca I.D., Uo M., Totsuka Y., Watari F.
    • Journal Title

      Key Engineering Materials 254-256

      Pages: 919-922

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Quantitative analysis of biological specimens by X-ray scanning analytical microscope2004

    • Author(s)
      Uo M., Tanaka M., Watari F.
    • Journal Title

      Journal of Biomedical Materials Research, PartB Applied Biomaterials 70B

      Pages: 146-151

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Three-dimensional topographic scanning electron microscope and Raman spectroscopic analyses of the irradiation effect on teeth by Nd:YAG, Er:YAG, and CO_2 lasers2004

    • Author(s)
      Yamada M.K., Uo M., Ohkawa S., Akasaka T., Watari F.
    • Journal Title

      Journal of Biomedical Materials Research, PartB Applied Biomaterials 71B

      Pages: 7-15

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Surface analysis of dental amalgams by x-ray photoelectron spectrometry and x-ray diffraction spectrometry2003

    • Author(s)
      Uo M., Berglund A., Cardenas J., Pohl L., Watari F., Bergman M., Sjoberg S.
    • Journal Title

      Dental Materials 19

      Pages: 639-644

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Cytotoxicity and bonding properties of dental ceramics2003

    • Author(s)
      Uo M., Sjogren G., Sundh A., Watari F., Bergman M., Lerner U.
    • Journal Title

      Dental Materials 19

      Pages: 497-492

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Tissue Response to a newly developed calcium phosphate cement containing succinic acid and carboxymethyl-chitin2003

    • Author(s)
      Yokoyama A., Matsuno H., Yamamoto S., Kawasaki T., Kohgo T., Uo M., Watari F.
    • Journal Title

      Journal of Biomedical Materials Research PartA 64A

      Pages: 491-501

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Discrimination between composite resin and teeth using fluorescence properties2003

    • Author(s)
      Tani K., Watari F., Uo M., Morota M.
    • Journal Title

      Dental Materials Journal 22

      Pages: 569-580

    • NAID

      110002983629

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Cytotoxicity and bonding properties of denta 1 ceramics2003

    • Author(s)
      Uo M., Sjogren G., Sundh A., Watari F., Bergman M., Lerner U.
    • Journal Title

      Dental Materials 19

      Pages: 487-492

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Tissue Response to a newly developed calcium phosphate cement containing succinic acid and carboxymethyl-chitin2003

    • Author(s)
      Yokoyama A., Matsuno H., Yamamoto S., Kawasaki T., Kohgo T., Uo M., Watari F.Nakasu M.
    • Journal Title

      Journal of Biomedical Materials Research 64 A

      Pages: 491-501

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Discrimination between composite resin and teeth using fluorescence properties2003

    • Author(s)
      Tani K., Watari F., Uo M., Morota M.
    • Journal Title

      Dental Materials Journal 22(4)

      Pages: 569-580

    • NAID

      110002983629

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Publications] Uo M., Berglund A., Cardenas J., Phl L., Watari F., Bergman M., Sjoberg S.: "Surface analysis of dental amalgams by x-ray photoelectron spectrometry and x-ray diffraction spectrometry"Dental Materials. 19. 639-644 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Uo M., Sjogren G., Sundh A., Watari F., Bergman M., Lerner U.: "Cytotoxicity and bonding properties of dental ceramics"Dental Materials. 19. 497-492 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Yokoyama A., Matsuno H., Yamamoto S., Kawasaki T., Kohgo T., Uo M., Watari F., Nakasu M.: "Tissue Response to a newly developed calcium phosphate cement containing succinic acid and carboxymetyl-chitin"Journal of Biomedical Materials Research PartA. 64A. 491-501 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Tani K., Watari F., Uo M., Morota M.: "Discrimination between composite resin and teeth using fluorescence properties"Dental Materials Journal. 22. 569-580 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Uo M., Watari F., Kohgo T.: "The application of X-ray scanning analytical microscope for the analysis of biological tissues"Journal of Dental Research. SI82. B-62 (2003)

    • Related Report
      2003 Annual Research Report

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Published: 2003-04-01   Modified: 2016-04-21  

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