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Neurophysiological study to reveal the relationship between sleep bruxism and gastroesophageal reflux (GER).

Research Project

Project/Area Number 15390634
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Orthodontic/Pediatric dentistry
Research InstitutionOKAYAMA UNIVERSITY

Principal Investigator

MIYAWAKI Shouichi  Okayama University, Graduate School of Medicine Dentistry and Pharmaceutial Sciences, Associate Professor, 大学院・医歯薬学総合研究科, 助教授 (80295807)

Co-Investigator(Kenkyū-buntansha) TAKANO Teruko (YAMAMOTO Teruko)  Okayama University, Graduate School of Medicine Dentistry and Pharmaceutial Sciences, Professor and Chair, 大学院・医歯薬学総合研究科, 教授 (00127250)
TANIMOTO Yuko  Okayama University, Graduate School of Medicine Dentistry and Pharmaceutial Sciences, Assistant Professor, 大学院・医歯薬学総合研究科, 助手 (20190754)
藤木 辰哉  岡山大学, 医学部・歯学部附属病院, 助手 (20322232)
Project Period (FY) 2003 – 2004
Project Status Completed (Fiscal Year 2004)
Budget Amount *help
¥13,000,000 (Direct Cost: ¥13,000,000)
Fiscal Year 2004: ¥900,000 (Direct Cost: ¥900,000)
Fiscal Year 2003: ¥12,100,000 (Direct Cost: ¥12,100,000)
KeywordsBruxism / pH-metry / Manometry / RMMA(Rhysmic masticatory mascle activity) / Temporomandibular disorder / Polysomnography / electromyogram(EMG) / electroencephalogram(EEG)
Research Abstract

Ten bruxism patients and 10 normal adults were used as subjects and they were matched for height, weight, age and sex. They did not have GER disease symptoms.
The bruxism group showed a significantly higher frequency of nocturnal bruxism episodes and a higher frequency and percentage of time of gastroesophageal reflux(GER) episodes with pH<4.0 and 5.0 than the control group. In the bruxism group, 100% of the GER episodes with pH<3.0 and 4.0 included both an RMMA episode and EMG burst whose duration was around 0.5 to 1.0 second, probably representing saliva swallowing. The majority of GER episodes with a pH of 4.0-5.0 also included both an RMMA episode and EMG burst, again probably due to saliva swallowing in the control and bruxism groups. The remaining minority of GER episodes with a pH of 4.0-5.0 contained only an EMG burst (saliva swallowing). The frequency of RMMA episodes after the PPI medication, which increased the gastric and esophageal pH, was significantly lower than that after the placebo medication in the control and bruxism groups.
Nocturnal bruxism may be secondary to nocturnal GER, occurring via sleep arousal, and often together with swallowing. The physiologic link between bruxism and increase in salivation needs to be investigated.

Report

(3 results)
  • 2004 Annual Research Report   Final Research Report Summary
  • 2003 Annual Research Report
  • Research Products

    (21 results)

All 2005 2004 2003 Other

All Journal Article (15 results) Publications (6 results)

  • [Journal Article] Occlusal force and condylar motion in patients with anterior open bite.2005

    • Author(s)
      Miyawaki, S. et al.
    • Journal Title

      J Dent Res 82(2)

      Pages: 133-137

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Annual Research Report 2004 Final Research Report Summary
  • [Journal Article] Occlusal force and condylar motion in patients with anterior open bite.2005

    • Author(s)
      S.Miyawaki, et al.
    • Journal Title

      Journal of Dental Research Vol.82

      Pages: 133-137

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Relationships among nocturnal jaw muscle activities, decreased esophageal pH, and sleep positions.2004

    • Author(s)
      Miyawaki, S. et al.
    • Journal Title

      Am J Orthod.Dentofac Orthop 126(5)

      Pages: 615-619

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Movement of the lateral and medial poles of the working condyle during mastication in patients with unilateral posterior crossbite.2004

    • Author(s)
      Miyawaki, S. et al.
    • Journal Title

      Am J Orthod Dentofac Orthop 126(5)

      Pages: 549-554

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Annual Research Report 2004 Final Research Report Summary
  • [Journal Article] Salivary flow rates during relaxing, clenching and chewing-like movement with maxillary occlusal splints.2004

    • Author(s)
      Miyawaki, S. et al.
    • Journal Title

      Am J Orthod Dentofac Orthop 126(3)

      Pages: 367-370

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Assessment of undergraduate orthodontic education : a correlation between written examination, laboratory work, and objective structured clinical examination (OSCE) of medical interviews.2004

    • Author(s)
      Miyawaki, S. et al.
    • Journal Title

      Orthodontic Waves 63(3)

      Pages: 71-75

    • NAID

      110004012030

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Relatioships among nocturnal jaw muscle activities, decreased esophageal pH, and sleep positions.2004

    • Author(s)
      S.Miyawaki, et al.
    • Journal Title

      Am J Orthod.Dentofac Orthop. Vol.126

      Pages: 615-619

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Movement of the lateral and medial poles of the working condyle during mastication in patients with unilateral posterior crossbite.2004

    • Author(s)
      S.Miyawaki, et al.
    • Journal Title

      Am J Orthod.Dentofac Orthop. Vol.126

      Pages: 549-554

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Salivary flow rates during relaxing, clenching and chewing-like movement with maxillary occlusal splints.2004

    • Author(s)
      S.Miyawaki, et al.
    • Journal Title

      Am J Orthod.Dentofac Orthop. Vol.126

      Pages: 367-370

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Assessment of undergraduate orthodontic education : a correlation between written examination, laboratory work, and objective structured clinical examination(OSCE) of medical interviews.2004

    • Author(s)
      S.Miyawaki, et al.
    • Journal Title

      Orthodontic Waves Vol.63

      Pages: 71-75

    • NAID

      110004012030

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Relatioships among nocturnal jaw muscle activities, decreased esophageal pH, and sleep positions.2004

    • Author(s)
      Miyawaki, S. et al.
    • Journal Title

      Am J Orthod Dentofac Orthop 126(5)

      Pages: 615-619

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Salivary flow rates during relaxing, clenching and chewing-like movement with maxillary occlusal splints.2004

    • Author(s)
      Miyawaki, S. et al.
    • Journal Title

      Am J Orthod.Dentofac Orthop 126(3)

      Pages: 367-370

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Assessment of undergraduate orthodontic education : a correlation between written examination, laboratory work, and objective structured clinical examination(OSCE) of medical interviews.2004

    • Author(s)
      Miyawaki, S. et al.
    • Journal Title

      Orthodontic Waves 63(3)

      Pages: 71-75

    • NAID

      110004012030

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Association between nocturnal bruxism and gastroesophageal reflux.2003

    • Author(s)
      Miyawaki, S. et al.
    • Journal Title

      Sleep 26(7)

      Pages: 888-892

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Annual Research Report 2004 Final Research Report Summary
  • [Journal Article] Association between nocturnal bruxism and gastroesophageal reflux.2003

    • Author(s)
      S.Miyawaki, et al.
    • Journal Title

      Sleep Vol.26

      Pages: 888-892

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Publications] Miyawaki, S.: "Association between noctumal brnxism and gastroesophageal reflux"Sleep. 26. 888-892 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] 宮脇正一: "矯正臨床に機能評価をどう取り入れていくか-口腔の基本的機能ならびに異常機能について-睡眠時のブラキシズムについて-最新の知見と矯正患者への対応-"中・四国矯正歯科学会雑誌. 15. 25-28 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Miyawaki, S.: "Factors associated with the stability of titanium screws placed in the posterior region for orthodontic anchorage"American Journal of Orthodontics and Dentofacial Orthopedics. 124. 373-378 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Miyawaki, S.: "Salivary flow rates during relaxing, clenching and chewing-like movement with maxillary occlusal splints"American Journal of Orthodontics and Dentofacial Orthopedics. (in press). (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Miyawaki, S.: "Movement of the lateral and medial poles of the working condyle during mastication in patients with unilateral posterior crossbite"American Journal of Orthodontics and Dentofacial Orthopedics. (in press). (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Fujiki, T.: "Relationship between maxillofacial morphology and deglutitive tongue movement in patients with anterior open bite"American Journal of Orthodontics and Dentofacial Orthopedics. 125. 160-167 (2004)

    • Related Report
      2003 Annual Research Report

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Published: 2003-04-01   Modified: 2016-04-21  

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