Neurophysiological study to reveal the relationship between sleep bruxism and gastroesophageal reflux (GER).
| Project/Area Number |
15390634
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Orthodontic/Pediatric dentistry
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| Research Institution | OKAYAMA UNIVERSITY |
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Principal Investigator |
MIYAWAKI Shouichi Okayama University, Graduate School of Medicine Dentistry and Pharmaceutial Sciences, Associate Professor, 大学院・医歯薬学総合研究科, 助教授 (80295807)
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| Co-Investigator(Kenkyū-buntansha) |
TAKANO Teruko (YAMAMOTO Teruko) Okayama University, Graduate School of Medicine Dentistry and Pharmaceutial Sciences, Professor and Chair, 大学院・医歯薬学総合研究科, 教授 (00127250)
TANIMOTO Yuko Okayama University, Graduate School of Medicine Dentistry and Pharmaceutial Sciences, Assistant Professor, 大学院・医歯薬学総合研究科, 助手 (20190754)
藤木 辰哉 岡山大学, 医学部・歯学部附属病院, 助手 (20322232)
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| Project Period (FY) |
2003 – 2004
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| Project Status |
Completed (Fiscal Year 2004)
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| Budget Amount *help |
¥13,000,000 (Direct Cost: ¥13,000,000)
Fiscal Year 2004: ¥900,000 (Direct Cost: ¥900,000)
Fiscal Year 2003: ¥12,100,000 (Direct Cost: ¥12,100,000)
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| Keywords | Bruxism / pH-metry / Manometry / RMMA(Rhysmic masticatory mascle activity) / Temporomandibular disorder / Polysomnography / electromyogram(EMG) / electroencephalogram(EEG) |
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| Research Abstract |
Ten bruxism patients and 10 normal adults were used as subjects and they were matched for height, weight, age and sex. They did not have GER disease symptoms.
The bruxism group showed a significantly higher frequency of nocturnal bruxism episodes and a higher frequency and percentage of time of gastroesophageal reflux(GER) episodes with pH<4.0 and 5.0 than the control group. In the bruxism group, 100% of the GER episodes with pH<3.0 and 4.0 included both an RMMA episode and EMG burst whose duration was around 0.5 to 1.0 second, probably representing saliva swallowing. The majority of GER episodes with a pH of 4.0-5.0 also included both an RMMA episode and EMG burst, again probably due to saliva swallowing in the control and bruxism groups. The remaining minority of GER episodes with a pH of 4.0-5.0 contained only an EMG burst (saliva swallowing). The frequency of RMMA episodes after the PPI medication, which increased the gastric and esophageal pH, was significantly lower than that after the placebo medication in the control and bruxism groups.
Nocturnal bruxism may be secondary to nocturnal GER, occurring via sleep arousal, and often together with swallowing. The physiologic link between bruxism and increase in salivation needs to be investigated.
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Report
(3 results)
Research Products
(21 results)
