• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Mesial orthodontic movement of rat molars after extraction of the adjacent first molar and

Research Project

Project/Area Number 15390640
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Orthodontic/Pediatric dentistry
Research InstitutionThe Nippon Dental University

Principal Investigator

YAGISHITA Hisao  The Nipponn Dental University, School of Life Dentistry at Tokyo, Associate Professor, 生命歯学部, 助教授 (50256989)

Co-Investigator(Kenkyū-buntansha) ANDO Fuhihito  The Nipponn Dental University, School of Life Dentistry at Tokyo, Lecturer, 生命歯学部, 講師 (90318543)
SHIMAZU Yoshihito  The Nipponn Dental University, School of Life Dentistry at Tokyo, Lecturer, 生命歯学部, 講師 (10297947)
NAKAHARA Rizako  The Nipponn Dental University, School of Life Dentistry at Tokyo, Professor, 生命歯学部, 教授 (90155804)
SATO Kaori  The Nipponn Dental University, School of Life Dentistry at Tokyo, Lecturer, 生命歯学部, 講師 (90287772)
AOBA Takaaki  The Nipponn Dental University, School of Life Dentistry at Tokyo, Professor, 生命歯学部, 教授 (30028807)
添野 雄一  日本歯科大学, 歯学部, 助手 (70350139)
Project Period (FY) 2003 – 2006
Project Status Completed (Fiscal Year 2006)
Budget Amount *help
¥12,400,000 (Direct Cost: ¥12,400,000)
Fiscal Year 2006: ¥2,700,000 (Direct Cost: ¥2,700,000)
Fiscal Year 2005: ¥2,700,000 (Direct Cost: ¥2,700,000)
Fiscal Year 2004: ¥2,700,000 (Direct Cost: ¥2,700,000)
Fiscal Year 2003: ¥4,300,000 (Direct Cost: ¥4,300,000)
KeywordsOrthodontic tooth movement / Root resorption / Rat / μCT / Alveolar bone remodeling / Tooth extraction / Drug delivery / Bone morphometry / 臼歯
Research Abstract

The present study aimed to develop a new orthodontic apparatus integrating a removable super-elastic nickel-titanium (NiTi) alloy closed coil springs. Male SD rats (5 weeks old) were used. Maxillary incisors were pinned and utilized as anchorage for a closed-coil appliance. At the same time, upper first molars were extracted. After 5 days interval for wound healing, the activated closed-coil appliance was placed between the fixed incisor and the second molar. Three types of fabricated NiTi closed coil springs were used to generate certain ranges of force 10-40gf. We first assessed the retainability and durability of the apparatus by placing NiTi coil springs at the position for various periods ranging from 4 days to 14 days. The results supported the practical usefulness of the apparatus by showing that most of the NiTi coil springs under investigation remained activated at position throughout the observation periods. Examination of animal specimens in conjunction with microfocus x-ray tomography (μCT) and 3D-reconstruction technology validated that the second and third molars executed mesial drifts, accompanying the force-induced deformation at the incisal-premaxillary bony suture. It is pertinent that alveolar bone modeling in the intraseptal region progressed markedly during tooth displacement, whereas the bodily tooth drift did not accompany any marked compression of periodontal ligament or ankylosis. We also developed experimental models using an Alzet osmotic pump for systemic-infusion of bisphosphonate during tooth movement. Histologic examination revealed the local variation in agent-dependent osteoclastic cell behavior during its systemic delivery period. The present orthodontic tooth movement model will be useful in a wide range of investigation of the kinetics of tooth displacement under magnitude/temporal characteristics, e.g., continuous versus intermittent force application.

Report

(5 results)
  • 2006 Annual Research Report   Final Research Report Summary
  • 2005 Annual Research Report
  • 2004 Annual Research Report
  • 2003 Annual Research Report
  • Research Products

    (27 results)

All 2006 2005 2004 Other

All Journal Article (23 results) Book (3 results) Publications (1 results)

  • [Journal Article] ラット臼歯の近心移動モデルに適用できるNiTiコイルスプリング可撤式矯正装置の開発2006

    • Author(s)
      中村 佳司
    • Journal Title

      Orthod Wave-Jpn Ed. 65・3

      Pages: 165-173

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] 日本歯科大学病理学教科での3次元動画教材に関するアンケート調査と使用経験2006

    • Author(s)
      島津 徳人
    • Journal Title

      日歯教誌 21・1

      Pages: 78-82

    • NAID

      10017419200

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Use of a removable NiTi coiled-spring for mesial drift of rat molars into extraction sockets2006

    • Author(s)
      Nakamura, K.
    • Journal Title

      Orthod. Waves Jpn. Ed. 65(3)

      Pages: 165-173

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Introduction of three-dimensional moving constructs as teaching materials into the oral pathology course2006

    • Author(s)
      Shimazu, Y.
    • Journal Title

      J.J.D.E.A. 21(1)

      Pages: 78-82

    • NAID

      10017419200

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] ラット臼歯の近心移動モデルに適用できるNiTiコイルスプリング可撤式矯正装置の開発2006

    • Author(s)
      中村 桂司
    • Journal Title

      Orthod Wave-Jpn Ed. 65・3

      Pages: 165-173

    • Related Report
      2006 Annual Research Report
  • [Journal Article] 日本歯科大学病理学教科での3次元動画教材に関するアンケート調査と使用経験2006

    • Author(s)
      島津徳人
    • Journal Title

      日歯教誌 21・1

      Pages: 78-82

    • NAID

      10017419200

    • Related Report
      2006 Annual Research Report
  • [Journal Article] ラット臼歯抜歯窩と歯根膜における破骨細胞の分化・活性化 : Bisphosphonate(HEBP)持続投与が及ぼす影響2005

    • Author(s)
      青柳 暁子
    • Journal Title

      小児歯誌 43・3

      Pages: 591-598

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Molecular mechanism for connective tissue destruction by dipeptidyl aminopeptidase IV produced by the periodontal pathogen Porphyromonas gingivalis2005

    • Author(s)
      Kumagai, Y.
    • Journal Title

      Infect. Immun. 73・5

      Pages: 2655-2664

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Discrete effects of continuous bisphosphonate administration on differentiation and activation of rat osteoclasts in alveolar sockets and periodontal alveolar bone2005

    • Author(s)
      Aoyagi, K.
    • Journal Title

      Jpn. J. Ped. Dent. 43(3)

      Pages: 591-598

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Molecular mechanism for connective tissue destruction by dipeptidyl aminopeptidase IV produced by the periodontal pathogen Porphyromonas gingivalis2005

    • Author(s)
      Kumagai, Y.
    • Journal Title

      Infect. Immun. 74(1)

      Pages: 2655-2664

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Formation and properties of bioapatites in mammals2005

    • Author(s)
      Aoba, T.
    • Journal Title

      Current Topics in Crystal Growth 7

      Pages: 31-38

    • Related Report
      2005 Annual Research Report
  • [Journal Article] ラット臼歯抜歯窩と歯根膜における破骨細胞の分化・活性化:Bisphosphonate(HEBP)持続投与が及ぼす影響2005

    • Author(s)
      青柳暁子
    • Journal Title

      小児歯誌 43

      Pages: 591-598

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Molecular mechanism for connective tissue destruction by dipeptidyl aminopeptidase IV produced by the periodontal pathogen Porphyromonas gingivalis2005

    • Author(s)
      Kumagai, Y.
    • Journal Title

      Infect.Immunol. 73

      Pages: 2655-2664

    • Related Report
      2005 Annual Research Report
  • [Journal Article] 病理学実習に向けたメディア教材の開発と病理診断テストによる学習効果のパフォーマンス・アセスメント2005

    • Author(s)
      柳下寿郎
    • Journal Title

      日歯教誌 21

      Pages: 101-107

    • Related Report
      2005 Annual Research Report
  • [Journal Article] 歯学部学生の病理診断能の向上を目指した実習カリキュラムと自習教材の開発2005

    • Author(s)
      柳下寿郎
    • Journal Title

      日歯教誌 20

      Pages: 326-332

    • NAID

      10015590900

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Formation and properties of bioapatites in mammals2005

    • Author(s)
      Aoba T.
    • Journal Title

      Current Topics in Crystal Growth (in press)

    • Related Report
      2004 Annual Research Report
  • [Journal Article] ラット上顎第一臼歯抜歯窩への後方臼歯の矯正学的移動 : μGT-立体構築法を併用した実験モデルの開発2004

    • Author(s)
      島津 徳人
    • Journal Title

      Orthod. Wave-Jpn. Ed. 63・2

      Pages: 71-77

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] マイクロフォーカスX線CT法による3次元構造解析 : 立体画像の構築と形態計測2004

    • Author(s)
      柬理 頼亮
    • Journal Title

      J. Oral Biosci. 46・3

      Pages: 67-73

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Mesial orthodontic movement of rat upper second molar after extraction of the adjacent first molar : development of an experimental model in conjunction with μCT and 3D-reconstruction technology2004

    • Author(s)
      Shimazu, Y.
    • Journal Title

      Orthod. Waves Jpn. Ed. 63(2)

      Pages: 71-77

    • NAID

      110004014952

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Use of microfocus x-ray computer tomography for 3D-image construction and quantitative morphoanalysis2004

    • Author(s)
      Kanri, Y.
    • Journal Title

      J. Oral Biosci. 46(3)

      Pages: 67-73

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Caries experience of fluoride-relative and - irrelative enamel malformations2004

    • Author(s)
      Nakahara Y.
    • Journal Title

      Oral Med.Pathol. 9

      Pages: 61-66

    • Related Report
      2004 Annual Research Report
  • [Journal Article] ラット上顎第一臼歯抜歯窩への後方臼歯の矯正学的移動:μCT-立体構築法を併用した実験モデルの開発2004

    • Author(s)
      島津徳人
    • Journal Title

      日歯矯誌 63・2

      Pages: 71-77

    • NAID

      110004014952

    • Related Report
      2004 Annual Research Report
  • [Journal Article] マウス顎関節の発生と形態形成に関する組織計量解析2004

    • Author(s)
      柬理頼亮
    • Journal Title

      J.Oral Biosci. 46・3

      Pages: 243-250

    • Related Report
      2004 Annual Research Report
  • [Book] 平成17年度病理学Web教材(学内LAN配信資料・冊子版)(青葉孝昭監修)2005

    • Author(s)
      日本歯科大学病理学講座編
    • Total Pages
      143
    • Publisher
      日本歯科大学出版
    • Related Report
      2005 Annual Research Report
  • [Book] 病理学実習標本の観察手引き2004

    • Author(s)
      青葉孝昭
    • Publisher
      青葉孝昭
    • Related Report
      2004 Annual Research Report
  • [Book] Biomineralization: formation, deversity, evolution and application2004

    • Author(s)
      Aoba T.
    • Publisher
      Kobayashi I., Ozawa H.
    • Related Report
      2004 Annual Research Report
  • [Publications] 島津徳人, 他4名: "ラット上顎第一臼歯抜歯窩への後方臼歯の矯正学的移動:μCT-立体構築法を併用した実験モデルの開発"Orthodontic Waves. (2004)

    • Related Report
      2003 Annual Research Report

URL: 

Published: 2003-04-01   Modified: 2016-04-21  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi