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Search for the biologically active substances from the marine invertebrates in the Caribbean

Research Project

Project/Area Number 15404010
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section海外学術
Research Field Chemistry related to living body
Research InstitutionKanazawa University

Principal Investigator

TSUKAMOTO Sachiko  Kanazawa University, Graduate School of Natural Science and Technology, Associate Professor, 自然科学研究科, 助教授 (40192190)

Project Period (FY) 2003 – 2004
Project Status Completed (Fiscal Year 2004)
Budget Amount *help
¥7,800,000 (Direct Cost: ¥7,800,000)
Fiscal Year 2004: ¥3,800,000 (Direct Cost: ¥3,800,000)
Fiscal Year 2003: ¥4,000,000 (Direct Cost: ¥4,000,000)
Keywordsbiological activity / marine invertebrates / drug discovery / Caribbean / 国際研究者交流 / アメリカ
Research Abstract

The marine environment has proven to be a rich source of extremely potent compounds that have demonstrated significant activities in antitumor, antiinflammatory, analgesia, immunomodulation, allergy, and antiviral assays. Especially, the marine invertebrates in the Caribbean afforded the variety of compounds. Among them ecteinascidin 743 was known to be an antitumor compound. In this project we collected marine invertebrates in the Caribbean and prepared samples for screening of drug discovery.

Report

(3 results)
  • 2004 Annual Research Report   Final Research Report Summary
  • 2003 Annual Research Report
  • Research Products

    (11 results)

All 2005 2004 2003 Other

All Journal Article (8 results) Publications (3 results)

  • [Journal Article] Himeic Acid A : A New Ubiquitin-Activating Enzyme Inhibibtor Isolated from a Marine-Derived Fungus, Aspergillus sp.2005

    • Author(s)
      Sachiko Tsukamoto
    • Journal Title

      Bioorg.Med.Chem.Lett. 15(1)

      Pages: 191-194

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Annual Research Report 2004 Final Research Report Summary
  • [Journal Article] Isolation of Parguerol and Isoparguerol as Neurotrophic Agents from the Sea Hare, Aplysia kurodai.2004

    • Author(s)
      Sachiko Tsukamoto
    • Journal Title

      Mar.Drugs 2(4)

      Pages: 170-175

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Annual Research Report 2004 Final Research Report Summary
  • [Journal Article] Girolline, an Antitumor Compound Isolated from a Sponge, Induces G2/M Cell Cycle Arrest and Accumulation of Polyubiquitinated p53.2004

    • Author(s)
      Sachiko Tsukamoto
    • Journal Title

      Biol.Pharm.Bull. 27(5)

      Pages: 699-701

    • NAID

      110003608834

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Annual Research Report 2004 Final Research Report Summary
  • [Journal Article] Aspermytin A : a new neurotrophic polyketide isolated from a marine-derived fungus of the genus Aspergillus.2004

    • Author(s)
      Sachiko Tsukamoto
    • Journal Title

      Bioorg.Med.Chem.Lett. 14(2)

      Pages: 417-420

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Annual Research Report 2004 Final Research Report Summary
  • [Journal Article] New Polyhydroxy Sterols : Proteasome Inhibitors from a Marine Sponge Acanthodendrilla sp.2003

    • Author(s)
      Sachiko Tsukamoto
    • Journal Title

      J.Nat.Prod 66(9)

      Pages: 1181-1185

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Three New Cytotoxic Sesterterpenes from a Marine Sponge Spongia sp.2003

    • Author(s)
      Sachiko Tsukamoto
    • Journal Title

      J.Nat.Prod 66(3)

      Pages: 438-440

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] New Polyhydroxy Sterols : Proteasome Inhibitors from a Marine Sponge Acanthodendrilla sp.2003

    • Author(s)
      Sachiko Tsukamoto
    • Journal Title

      J.Nat.Prod. 66(9)

      Pages: 1181-1185

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Three New Cytotoxic Sesterterpenes from a Marine Sponge Spongia sp.2003

    • Author(s)
      Sachiko Tsukamoto
    • Journal Title

      J.Nat.Prod. 66(3)

      Pages: 438-440

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Publications] Sachiko Tsukamoto: "Aspermytin A : a new neurotrophic polyketide isolated from a marine-derived fungus of the genus Aspergillus"Bioorg.Med.Chem.Lett.. 14(2). 417-420 (2004)

    • Related Report
      2003 Annual Research Report
  • [Publications] Sachiko Tsukamoto: "New Polyhydroxy Sterols : Proteasome Inhibitors from a Marine Sponge Acanthodendrilla sp."J.Nat.Prod. 66(9). 1181-1185 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Sachiko Tsukamoto: "Three New Cytotoxic Sesterterpenes from a Marine Sponge Spongia sp."J.Nat.Prod.. 66(3). 438-440 (2003)

    • Related Report
      2003 Annual Research Report

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Published: 2003-04-01   Modified: 2019-04-12  

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