| Project/Area Number |
15405005
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 海外学術 |
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| Research Field |
Risk sciences of radiation/Chemicals
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| Research Institution | Nagasaki University |
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Principal Investigator |
SOYANO Kiyoshi Nagasaki University, Institute for East China Sea Research, Associate Professor, 環東シナ海海洋環境資源研究センター, 助教授 (80260735)
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| Co-Investigator(Kenkyū-buntansha) |
ISHIMATSU Atsushi Nagasaki University, Institute for East China Sea Research, Professor, 環東シナ海海洋環境資源研究センター, 教授 (00184565)
TAKAO Yuji Nagasaki University, Faculty of Environmental Studies, Associate Professor, 環境科学部, 助教授 (20206709)
NAGAE Masaki Nagasaki University, Faculty of Environmental Studies, Associate Professor, 環境科学部, 助教授 (00315227)
ISHIBASHI Yasuhiro Nagasaki University, Environmental Protection Center, Assistant Professor, 共同研究交流センター, 助手 (00212928)
HARA Akihiko Hokkaido Univ., Graduate School of Fisheries Science, Professor, 大学院・水産科学研究院, 教授 (40091483)
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| Project Period (FY) |
2003 – 2005
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| Project Status |
Completed (Fiscal Year 2005)
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| Budget Amount *help |
¥12,200,000 (Direct Cost: ¥12,200,000)
Fiscal Year 2005: ¥3,700,000 (Direct Cost: ¥3,700,000)
Fiscal Year 2004: ¥3,800,000 (Direct Cost: ¥3,800,000)
Fiscal Year 2003: ¥4,700,000 (Direct Cost: ¥4,700,000)
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| Keywords | Endocrine disruption / grey mullet / abnormality / vitellogenin / East China Sea |
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| Research Abstract |
It is well known that endocrine and sexual disruptions in wild teleosts are induced by endocrine disrupting chemicals which have an estrogen-like function. However, the actualities of contamination by these substances in aquatic environment of coastal waters are not investigated well in Japan and East Asia. We carried out the monitoring of environmental estrogens in marine and estuarine areas using wild grey mullet (Mugil cephalus). In this research, we tried to determine the plasma concentrations of vitellogenin (VTG) which is the major yolk protein produced by the liver under the influence of estrogen. Moreover, we observed gonadal abnormalities using histological technique.
VTG levels of grey mullets in the bay areas were significantly higher than the ones of fish collected in the open sea. In male and immature female fish of Tokyo Bay, Osaka Bay, Japan, VTG levels were the same as mature female fish. These areas are fed by a large amount of industrial and domestic sewage and effluent. VTG level is generally very low (<1μg/ml) in male and immature fish, because vitellogenic oocytes are not included in the gonad of these fish. These results indicate that VTG synthesis was induced by exogenous estrogen-like substance (environmental estrogen). VTG levels of the fish collected from South part of Korea were higher than another place of Korea.
We will start the new survey of estrogenic contaminations in costal waters in the East China Sea with scientist of Korea and China. Moreover, we have a plan to construct the network of scientist for the research of endocrine disruption in East Asia.
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