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Investigation of Indonesian Marine Organisms as Medicinal Resources

Research Project

Project/Area Number 15406005
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section海外学術
Research Field Environmental pharmacy
Research InstitutionOsaka University

Principal Investigator

KOBAYASHI Motomasa  Osaka University, Graduate school of Pharmaceutical Sciences, professor, 薬学研究科, 教授 (40116033)

Co-Investigator(Kenkyū-buntansha) HIGA Tatsuo  University of the Ryukyus, Department of Chemistry, Biology, and Marine Science, professor, 理学部, 教授 (10101461)
TANAKA Junichi  University of the Ryukyus, Department of Chemistry, Biology, and Marine Science, associate professor, 理学部, 助教授 (20163529)
AOKI Shunji  Osaka University, Graduate school of Pharmaceutical Sciences, lecturer, 薬学研究科, 講師 (60252699)
Project Period (FY) 2003 – 2005
Project Status Completed (Fiscal Year 2005)
Budget Amount *help
¥13,000,000 (Direct Cost: ¥13,000,000)
Fiscal Year 2005: ¥4,200,000 (Direct Cost: ¥4,200,000)
Fiscal Year 2004: ¥4,200,000 (Direct Cost: ¥4,200,000)
Fiscal Year 2003: ¥4,600,000 (Direct Cost: ¥4,600,000)
KeywordsIndonesia / marine invertebrate / medicinal resource / marine sponge / bioactivity
Research Abstract

Indonesia consists of more than 17,000 islands distributed along the equator stretched over the two oceans. The Indonesian waters are known to have diverse species of sessile organisms such as sponges and soft corals. However, their regional and biological distribution and biomedical potential are scarcely understood. We, a group of scientists from both Indonesia and Japan, aim to conduct survey, collection, and chemical and pharmaceutical investigation of these organisms. Owing to the deterioration of coastal environment caused by industrial and municipal effluents and also by sedimentation of red clay discharged from land development, existence of sessile marine organisms are endangered in the coasts of Japan. This situation is not confined only to Japan. Similar situation is developing in Indonesia, especially along the coasts of Jakarta and other coastal cities. The problem is serious not only from the viewpoint of environmental conservation.
Considering these situations, we started the study of Indonesian marine organisms as sources of lead compounds for new medicines before some of these species disappear from the coastal waters. The present research is carried out as a collaborative project of Pusat Penelitian dan Pengembangan Oseanologi (Research and Development Centre for Oceanology)-LIPI, Lampung University, Diponegoro University, Indonesia and Osaka University and University of the Ryukyus, Japan. We have proceeded survey of marine invertebrates at Lampung in Sumatra Island in 2003, Carita in Java Island in 2004, and Biak Island in 2005 as shown below. 1) Search for diversity and correction of marine invertebrates by SCUBA diving. 2) Isolation of bioactive constituents from those marine invertebrates. We have already isolated several anti-tumor active constituents (cell cycle inhibitor or anti-angiogenesis). 3) Separation of marine microorganism from marine sediment and investigation of bioactive constituents of those marine microorganisms.

Report

(4 results)
  • 2005 Annual Research Report   Final Research Report Summary
  • 2004 Annual Research Report
  • 2003 Annual Research Report
  • Research Products

    (93 results)

All 2006 2005 2004 2003 Other

All Journal Article (84 results) Publications (9 results)

  • [Journal Article] Bastadin 6, a Spongean Brominated Tyrosine Derivative, Inhibits Tumor Angiogenesis by Inducing Selective Apoptosis to Endothelial Cells2006

    • Author(s)
      S.Aoki et al.
    • Journal Title

      ANTI-CANCER DRUGS 17

      Pages: 269-278

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Cortistatins A, B, C, and D, Anti-Angiogenic Steroidal Alkaloids, from the Marine Sponge Corticium simplex2006

    • Author(s)
      S.Aoki et al.
    • Journal Title

      J.Am.Chem.Soc. 128

      Pages: 3148-3149

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Aaptamine, a spongean alkaloid, activates p21 promoter in a p53-independent manner2006

    • Author(s)
      S.Aoki et al.
    • Journal Title

      BIOCHEM.BIOPHYS.RES.COMMUN. 342

      Pages: 101-106

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Hepatitis C virus-related internal ribosome entry sites are found in multiple genera of the family Picornaviridae2006

    • Author(s)
      LS.Chard et al.
    • Journal Title

      J.GEN.VIROL. 87

      Pages: 927-936

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Bastadin 6, a spongean brominated tyrosine derivative, inhibits tumor angiogenesis by inducing selective apoptosis to endothelial cells2006

    • Author(s)
      Aoki S, Cho S-H, Ono M, Kuwano T, Nakao S, Kuwano M, Nakagawa S, Gao JQ, Mayumi T, Shibuya M, Kobayashi M
    • Journal Title

      ANTI-CANCER DRUGS 17

      Pages: 269-278

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Cortistatins A, B, C, and D, anti-angiogenic steroidal alkaloids, from the marine sponge Corticium simplex2006

    • Author(s)
      Aoki S, Watanabe Y, Sanagawa M, Setiawan A, Kotoku N, Kobayashi M
    • Journal Title

      JOURNAL OF AMERICAN CHEMICAL SOCIETY 128

      Pages: 3148-3149

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Aaptamine, a spongean alkaloid, activates p21 promoter in a p53-independent manner2006

    • Author(s)
      Aoki S, Kong D, Suna H, Sowa Y, Sakai T, Setiawan A, Kobayashi M
    • Journal Title

      BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 342

      Pages: 101-106

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Hepatitis C virus-related internal ribosome entry sites are found in multiple genera of the family Picornaviridae2006

    • Author(s)
      Chard LS, Bordeleau M-E, Pelletier J, Tanaka J, Belsham GJ
    • Journal Title

      J.GEN.VIROL. 87

      Pages: 927-936

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Absolute stereo-structure of kendarimide a, a novel MDR modulator, from a marine sponge.2005

    • Author(s)
      N.Kotoku et al.
    • Journal Title

      HETEROCYCLES 65

      Pages: 563-578

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Annual Research Report 2005 Final Research Report Summary
  • [Journal Article] Shimalactone A, a novel polyketide, from marine-derived fungus Emericella variecolor GF10.2005

    • Author(s)
      H.Wei et al.
    • Journal Title

      Tetrahedron 61

      Pages: 8054-8058

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Annual Research Report 2005 Final Research Report Summary
  • [Journal Article] Efficient total synthesis of bastadin 6, an anti-angiogenic brominated tyrosine-derived metabolite from marine sponge.2005

    • Author(s)
      N.Kotoku et al.
    • Journal Title

      Tetrahedron 61

      Pages: 7211-7218

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Annual Research Report 2005 Final Research Report Summary
  • [Journal Article] GSH inhibits trypsinization of the C-terminal half of human MRP1.2005

    • Author(s)
      X-Q.Ren et al.
    • Journal Title

      J.Biol.Chem. 280

      Pages: 6231-6237

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Annual Research Report 2005 Final Research Report Summary
  • [Journal Article] MRP1 mutated in the L-O region transports SN-38 but not leukotriene C-4 or estradiol-17 (beta-D-glucuronate)2005

    • Author(s)
      T.Noguchi et al.
    • Journal Title

      BIOCHEMICAL PHARMACOLOGY 70

      Pages: 1056-1065

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Polycitorols A and B, New Tricyclic Alkaloids from an Ascidian2005

    • Author(s)
      H-H.Issa et al.
    • Journal Title

      Mar.Drugs 3

      Pages: 78-83

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Structural Basis of Swinholide A Binding to Actin.2005

    • Author(s)
      A.Vadim et al.
    • Journal Title

      Chemistry & Biology 12

      Pages: 287-291

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Fluorescent Kabiramides : New Probes to Quantify Actin in Vitro and in Vivo2005

    • Author(s)
      C Petchprayoon et al.
    • Journal Title

      Bioconjugate Chem. 16

      Pages: 1382-1389

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Annual Research Report 2005 Final Research Report Summary
  • [Journal Article] Chemical diversity of Sarcophyton soft corals in Okinawa2005

    • Author(s)
      J.Tanaka et al.
    • Journal Title

      GALAXEA 7

      Pages: 1-9

    • NAID

      130003670756

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Diverse metabolites of coral reef organisms2005

    • Author(s)
      J.Tanaka et al.
    • Journal Title

      Pure Appl.Chem. 77

      Pages: 83-89

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Annual Research Report 2005 Final Research Report Summary
  • [Journal Article] GSH inhibits trypsinization of the C-terminal half of human MRP12005

    • Author(s)
      Ren XQ, Furukawa T, Nakajima Y, Takahashi H, Aoki S, Sumizawa T, Haraguch M, Kobayashi M, Chijiiwa K, Akiyama S
    • Journal Title

      JOURNAL OF BIOLOGICAL CHEMISTRY 280

      Pages: 6231-6237

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Absolute stereo-structure of kendarimide A, a novel MDR modulator, from a marine sponge2005

    • Author(s)
      Kotoku N, Cao LW, Aoki S, Kobayashi M
    • Journal Title

      HETEROCYCLES 65

      Pages: 563-578

    • NAID

      40006650944

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Shimalactone A, a novel polyketide, from marine-derived fungus Emericella variecolor GF102005

    • Author(s)
      Wei H, Itoh T, Kinoshita M, Kotoku N, Aoki S, Kobayashi M
    • Journal Title

      TETRAHEDRON 61

      Pages: 8054-8058

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] MRP1 mutated in the L-0 region transports SN-38 but not leukotriene C-4 or estradiol-17 (beta-D-glucuronate)2005

    • Author(s)
      Noguchi T, Ren XQ, Aoki S, Igarashi Y, Che XF, Nakajima Y, Takahashi H, Mitsuo R, Tsujikawa K, Sumizawa T, Haraguchi M, Kobayashi M, Goto S, Kanehisa M, Aikou T, Akiyama S, Furukawa T
    • Journal Title

      BIOCHEMICAL PHARMACOLOGY 70

      Pages: 1056-1065

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Chemical diversity of Sarcophyton soft corals in Okinawa2005

    • Author(s)
      Tanaka J, Yoshida T, Benayahu Y
    • Journal Title

      GALAXEA 7

      Pages: 1-9

    • NAID

      130003670756

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Polycitrols A and B, new tricyclic alkaloids from an ascidian2005

    • Author(s)
      Issa HH, Tanaka J, Rachmat R, Setiawan A, Trianto A, Higa T
    • Journal Title

      MARINE DRUGS 3

      Pages: 78-83

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Fluorescent kabiramides : new probes to quantify actin in vitro and in vivo2005

    • Author(s)
      Petchaprayoon C, Suwanborirux K, Tanaka J, Yan Y, Sakata T, Marriott G
    • Journal Title

      BIOCONJUGATE CHEMISTRY 16

      Pages: 1382-1389

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Structural basis of swinholide A binding to actin2005

    • Author(s)
      Klenchin VA, King R, Tanaka J, Marriott G, Rayment I
    • Journal Title

      CHEMSTRY & BIOLOGY 12

      Pages: 287-291

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Diverse metabolites of coral reef organisms2005

    • Author(s)
      Tanaka J, Kuniyoshi M, Tanaka C, Issa HH, Balansa W, Otsuka M, Githige WP, Higa T
    • Journal Title

      PURE & APPLIED CHEMISTRY 77

      Pages: 83-89

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Polycitorols A and B, New Tricyclic Alkaloids from an Ascidiam2005

    • Author(s)
      H-H.Issa et al.
    • Journal Title

      Mar.Drugs 3

      Pages: 78-83

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Structural Basis of Swinbolide A Binding to Actin.2005

    • Author(s)
      Vadim A. et al.
    • Journal Title

      Chemistry & Biology 12

      Pages: 287-291

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Diverse metabolites from coral reef organisms2005

    • Author(s)
      J.Tanaka, T.Higa et al.
    • Journal Title

      Pure and Applied Chem. 77

      Pages: 83-89

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Sesquiterpene aminoquinones, from a marine sponge, induce erythroid differentiation in human chronic myelogenous leukemia, K562 cells.2004

    • Author(s)
      S.Aoki et al.
    • Journal Title

      Chem.Pharm.Bull. 52

      Pages: 935-937

    • NAID

      110003615689

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Kendarimide A, a novel peptide reversing P-glycoprotein-mediated multidrug resistance in tumor cells, from a marine sponge of Haliclona sp.2004

    • Author(s)
      S.Aoki et al.
    • Journal Title

      Tetrahedron 60

      Pages: 7053-7059

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Erythroid differentiation in K562 chronic myelogenous cellsinduced by crambescidin 800, a pentacyclic guanidine alkaloid2004

    • Author(s)
      S.Aoki et al.
    • Journal Title

      ANTICANCER RESEARCH 24

      Pages: 2325-2330

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] New analogue of arenastatin A, a potent cytotoxic spongean depsipeptide, with anti-tumor activity2004

    • Author(s)
      N.Murakami et al.
    • Journal Title

      BIOORG.MED.CHEM.LETT. 14

      Pages: 2597-2601

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Cytotoxic sesquiterpenes, 6-epi-ophiobolin G and 6-epi-ophioblin N, from marine derived fungus Emericella varuecolor GF10.2004

    • Author(s)
      Wei H et al.
    • Journal Title

      Tetrahedron 60

      Pages: 6015-6019

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Synthesis of a bioprobe for elucidation of target molecule of spongean anti-malarial peroxides2004

    • Author(s)
      N.Murakami et al.
    • Journal Title

      BIOORG.MED.CHEM.LETT. 14

      Pages: 3513-3516

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Structure-activity relationship of anti-malarial spongean peroxides having a 3-methoxy-1,2-dioxane structure.2004

    • Author(s)
      M.Kawanishi et al.
    • Journal Title

      BIOORG.MED.CHEM. 12

      Pages: 5297-5307

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Briarane diterpenes of two species of octocorals, Ellisella sp. and Pteroeides sp.2004

    • Author(s)
      C.Tanaka et al.
    • Journal Title

      J Nat.Prod. 67

      Pages: 1368-1373

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Absolute stereochemistry of ulapualide A2004

    • Author(s)
      JS.Alligham et al.
    • Journal Title

      ORGANIC LETTERS 6

      Pages: 597-599

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Function of the ABC signature sequences in the human multidrug resistance protein 1.2004

    • Author(s)
      X-Q.Ren et al.
    • Journal Title

      MOLECULAR PHARMACOLOGY 65

      Pages: 1536-1542

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Function of the ABC signature sequences in the human multidrug resistance protein 12004

    • Author(s)
      Ren XQ, Furukawa T, Haraguchi M, Sumizawa T, Aoki S, Kobayashi M, Akiyama S
    • Journal Title

      MOLECULAR PHARMACOLOGY 65

      Pages: 1536-1542

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] New analogue of arenastatin A, a potent cytotoxic spongean depsipeptide, with anti-tumor activity2004

    • Author(s)
      Murakami N, Tamura S, Koyama K, Sugimoto M, Maekawa R, Kobayashi M
    • Journal Title

      BIOORGANIC & MEDICINAL CHEMISTRY LETTERS 14

      Pages: 2597-2601

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Cytotoxic sesquiterpenes, 6-epi-ophiobolin G and 6-epi-ophiobolin N, from marine derived fungus Emericella variecolor GF10.2004

    • Author(s)
      Wei H, Itoh T, Kinoshita K, Nakai Y, Kurotaki M, Kobayashi M
    • Journal Title

      TETRAHEDRON 60

      Pages: 6015-6019

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Smenospongine, a spongean sesquiterpene aminoquinone, induces erythroid differentiation in K562 cells2004

    • Author(s)
      Aoki S, Kong D, Matsui K, Kobayashi M
    • Journal Title

      ANTI-CANCER DRUGS 15

      Pages: 363-369

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Synthesis of a bioprobe for elucidation of target molecule of spongean anti-malarial peroxides2004

    • Author(s)
      Murakami N, Kawanishi M, Itagaki S, Horii T, Kobayashi M
    • Journal Title

      BIOORGANIC & MEDICINAL CHEMISTRY LETTERS 14

      Pages: 3513-3516

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Kendarimide A, a novel peptide reversing P-glycoprotein-mediated multidrug resistance in tumor cells, from a marine sponge of Haliclona sp.2004

    • Author(s)
      Aoki S, Cao L, Matsui K, Rachmat R, Akiyama S, Kobayashi M
    • Journal Title

      TETRAHEDRON 60

      Pages: 7053-7059

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Sesquiterpene aminoquinones, from a marine sponge, induce erythroid differentiation in human chronic myelogenous leukemia, K562 cells2004

    • Author(s)
      Aoki S, Kong D, Matsui H, Rachmat R, Kobayashi M
    • Journal Title

      CHEM.PHARM.BULL. 52

      Pages: 935-937

    • NAID

      110003615689

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Erythroid differentiation in K562 myelogenous cells induced by crambescidin 800, a pentacyclic guanidine alkaloid2004

    • Author(s)
      Aoki S, Kong D, Matsui H, Kobayashi M
    • Journal Title

      ANTICANCER RESEARCH 24

      Pages: 2325-2330

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Structure-activity relationship of anti-malarial spongean peroxides having a 3-methoxy-1,2-dioxane structure2004

    • Author(s)
      Kawanishi M, Kotoku N, Itagaki S, Horii T, Kobayashi M
    • Journal Title

      BIOORGANIC & MEDICINAL CHEMISTRY 12

      Pages: 5297-5307

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Briarane diterpenes of two species of octocorals, Ellisella sp. and Pteroeides sp.2004

    • Author(s)
      Tanaka C, Yamamoto Y, Otsuka M, Tanaka J, Ichiba T, Marriott G, Rachmat R, Higa T
    • Journal Title

      JOURNAL OF NATURAL PRODUCTS 67

      Pages: 1368-1373

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Absolute stereochemistry of ulapualide A2004

    • Author(s)
      Alligham JS, Tanaka J, Marriott G, Rayment I
    • Journal Title

      ORGANIC LETTERS 6

      Pages: 597-599

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Cytotoxic sesterterpenes, 6-epi-ophiobolin G and 6-epi-ophiobolin N, from marine derived fungus Emericella variecolor GF102004

    • Author(s)
      Wei H, M.Kobayashi et al.
    • Journal Title

      TETRAHEDRON 60

      Pages: 6015-6019

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Smenospongine, a spongean sesquiterpene aminoquinone, induces erythroid differentiation in K562 cells.2004

    • Author(s)
      S.Aoki, M.Kobayashi et al.
    • Journal Title

      ANTI-CANCER DRUGS 15

      Pages: 363-369

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Sesquiterpene aminoquinones, from a marine sponge, induce erythroid differentiation in human chronic myelogenous leukemia, K562 cells.2004

    • Author(s)
      S.Aoki, M.Kobayashi et al.
    • Journal Title

      Chem.Pharm.Bull. 52

      Pages: 935-937

    • NAID

      110003615689

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Kendarimide A, a novel peptide reversing P-glycoprotein-mediated multidrug resistance in tumor cells, from a marine sponge of Haliclona2004

    • Author(s)
      S.Aoki, M.Kobayashi et al.
    • Journal Title

      TETRAHEDRON 60

      Pages: 7053-7059

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Briarane diterpenes from two species of octocorals, Ellisella sp. and Pteroeides sp.2004

    • Author(s)
      J.Tanaka, T.Higa et al.
    • Journal Title

      J.Nat.Prod. 67

      Pages: 1368-1373

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Stereostructure of komodoquinone A, a neuritogenic anthracycline, from marine Streptomyces sp.KS32003

    • Author(s)
      T.Itoh et al.
    • Journal Title

      Chem.Pharm.Bull. 51

      Pages: 1402-1404

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Komodoquinone A, a novel neuritogenic anthracycline, from marine Streptomyces sp.KS3.2003

    • Author(s)
      T.Itoh et al.
    • Journal Title

      J Nat.Prod. 66

      Pages: 1373-1377

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Binding site(s) on P-glycoprotein for a newlysynthesized photoaffinity analog of agosterol A2003

    • Author(s)
      M.Mitsuo et al.
    • Journal Title

      Oncology Research 14

      Pages: 39-48

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] New anti-malarial peroxides with in vivo potency derived from spongean metabolites.2003

    • Author(s)
      N.Murakami et al.
    • Journal Title

      BIOORG.MED.CHEM.LETT. 13

      Pages: 4081-4084

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Malformation of immature starfish oocytes by theonellapeptolide Ie, a tridecapeptide lactone from a marine sponge Petrosia species, through disturbance of cortical F-actin distribution2003

    • Author(s)
      E.Ohta et al.
    • Journal Title

      BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY 67

      Pages: 1908-1915

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Reversal of the resistance to STI571 in human chronic myelogenous leukemia K562 cells.2003

    • Author(s)
      M.Mukai et al.
    • Journal Title

      Cancer Sci. 94

      Pages: 557-563

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Localization of the GSH-dependent photolabelling site of an agosterol A analog on human MRP1.2003

    • Author(s)
      X-Q.Ren et al.
    • Journal Title

      Br J Pharmacol. 138

      Pages: 1553-1561

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] In situ photoaffinity labeling of the target protein for lembehyne A, a neuronal differentiation inducer2003

    • Author(s)
      S.Aoki et al.
    • Journal Title

      FEBS Lett. 544

      Pages: 223-227

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Pyridoacridine alkaloids inducing neuronal differentiation in a neuroblastoma cell line, from marine sponge Biemna fortis2003

    • Author(s)
      S.Aoki et al.
    • Journal Title

      Bioorg.Med.Chem. 11

      Pages: 1969-1973

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] New semisynthetic quassinoids with in vivo antimalarial activity2003

    • Author(s)
      N.Murakami et al.
    • Journal Title

      J.Med.Chem. 46

      Pages: 638-641

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Trisoxazole macrolide toxins mimic the binding of actin-capping proteins to actin2003

    • Author(s)
      VA.Klenchin et al.
    • Journal Title

      NATURE STUCTUREL BIOLOGY 10

      Pages: 1058-1063

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] New cytotoxic sesterterpenes from an Okinawan marine sponge, Ircinia sp.2003

    • Author(s)
      HH.Issa et al.
    • Journal Title

      J Nat.Prod. 66

      Pages: 251-254

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Floresolides A-C, new merosesquiterpenes from an Indonesian tunicate Aplidium sp.2003

    • Author(s)
      HH.Issa et al.
    • Journal Title

      Tetrahedron Lett. 44

      Pages: 1243-1245

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Biomolecular mimicry in the actin cytoskeleton : mechanisms underlying the cytotoxicity of kabiramide C and related macrolides2003

    • Author(s)
      J.Tanaka et al.
    • Journal Title

      PROC.NAT.ACAD.SCI.USA 100

      Pages: 13851-13856

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Stereostructure of komodoquinone A, a neuritogenic anthracycline, from marine Streptomyces sp.KS32003

    • Author(s)
      Itoh T, Kinoshita M, Wei H, Kobayashi M
    • Journal Title

      CHEM.PHARM.BULL. 51

      Pages: 1402-1404

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Komodoquinone A, a novel neuritogenic anthracycline, from marine Streptomyces sp.KS32003

    • Author(s)
      Itoh T, Kinoshita M, Aoki S, Kobayashi M
    • Journal Title

      J.NATURAL PRODUCTS 66

      Pages: 1373-1377

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Binding site(s) on P-glycoprotein for a newly synthesized photoaffinity analog of agosterol A2003

    • Author(s)
      Mitsuo M, Noguchi T, Nakajima Y, Aoki S, Ren X.-Q, Sumizawa T, Haraguchi M, Kobayashi M, Baba M, Nagata Y, Akiyama S, Furukawa T
    • Journal Title

      ONCOLOGY RESEARCH 14

      Pages: 39-48

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] New anti-malarial peroxides with in vivo potency derived from spongean metabolites2003

    • Author(s)
      Murakami N, Kawanishi M, Mostaqul H.M, Li J, Itagaki S, Horii T, Kobayashi M
    • Journal Title

      BIOORGANIC MEDICINAL CHEMISTRY LETTERS 13

      Pages: 4081-4084

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Malformation of immature starfish oocytes by theonellapeptolide Ie, a tridecapeptide lactone from a marine sponge Petrosia species, through disturbance of cortical F-actin distribution2003

    • Author(s)
      Ohta E, Okada H, Ohta S, Kobayashi M, Kitagawa I, Horiike S, Takahashi T, Hosoya H, Yamamoto K, Ikegami S
    • Journal Title

      BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY 67

      Pages: 1908-1915

    • NAID

      110002694326

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Reversal of the resistance to STI571 in human chronic myelogenous leukemia K562 cells2003

    • Author(s)
      Mukai M, Che X.-F, Furukawa T, Sumizawa T, Aoki S, Ren X.-Q, Haraguchi M, Sugimoto Y, Kobayashi M, Takamatsu H, Akiyama S
    • Journal Title

      CANCER SCIENCE 94

      Pages: 557-563

    • NAID

      10011689584

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Localization of the GSH-dependent photolabelling site of an agosterol A analog on human MRP12003

    • Author(s)
      Ren X-Q, Furukawa T, Aoki S, Sumizawa T, Haraguchi M, Che X.-F, Kobayashi M, Akiyama S
    • Journal Title

      BRITISH J.PHARMACOLOGY 138

      Pages: 1553-1561

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] In situ photoaffinity labeling of the target protein for lembehyne A, a neuronal differentiation inducer2003

    • Author(s)
      Aoki S, Matsui K, Takata T, Kobayashi M
    • Journal Title

      FEBS LETTERS 544

      Pages: 223-227

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Pyridoacridine alkaloids inducing neuronal differentiation in a neuroblastoma cell line, from marine sponge Biemna fortis2003

    • Author(s)
      Aoki S, Wei H, Matsui K, Rachmat R, Kobayashi M
    • Journal Title

      BIOORGANIC MEDICINAL CHEMISTRY 11

      Pages: 1969-1973

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] New semisynthetic quassinoids with in vivo antimalarial activity2003

    • Author(s)
      Murakami N, Sugimoto M, Kawanishi M, Tamura S, Kim H.-S, Begum K, Wataya Y, Kobayashi M
    • Journal Title

      J.MEDICINAL CHEMISTRY 46

      Pages: 638-641

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Biomolecular mimicry in the actin cytoskeleton : mechanisms underlying the cytotoxicity of kabiramide C and related macrolides2003

    • Author(s)
      Tanaka J, Yan Y, Choi J, Bai J, Klenchin VA, Rayment I, Marriott G
    • Journal Title

      PROC.NAT.ACAD.SCI.USA 100

      Pages: 13851-13856

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Trisoxazole macrolide toxins mimic the binding of actin-capping proteins to actin2003

    • Author(s)
      Klenchin VA, Allingham JS, King R, Tanaka J, Marriott G, Rayment I
    • Journal Title

      NATURE STUCTUREL BIOLOGY 10

      Pages: 1058-1063

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] New cytotoxic sesterterpenes from an Okinawan marine sponge, Ircinia sp.2003

    • Author(s)
      Issa HH, Tanaka J, Higa T
    • Journal Title

      JOURNAL OF NATURAL PRODUCTS 66

      Pages: 251-254

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Floresolides A-C, new merosesquiterpenes from an Indonesian tunicate Aplidium sp.2003

    • Author(s)
      Issa HH, Tanaka J, Higa T, Rachmat R
    • Journal Title

      TETRAHEDRON LETTERS 44

      Pages: 1243-1245

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Publications] S.Aoki: "In situ photoaffinity labeling of the target protein for lembehyne A, a neuronal differentiation inducer"FEBS Letters. 544. 223-227 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] S.Aoki: "Pyridoacridine alkaloids inducing neuronal differentiation in a neuroblastbma cell line, from marine sponge Biemna fortis"Bioorg.Med.Chem.. 11. 1969-1973 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] N.Murakami: "New semisynthetic quassinoids with in vivo antimalarial activity"J.Med.Chem.. 46. 638-641 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] M.Mitsuo: "Binding site(s) on P-glycoprotein for a synthesized photoaffinity analog of agosterol A"Oncology Research. 14. 39-48 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] H.H.Issa: "New cytotoxic sesterterpenes from an Okinawan marine sponge, Ircinia sp."J.Nat.Prod.. 66. 251-254 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] H.H.Issa: "Floresolides A-C, new metacyclophane hydroquinone lactones from an Ascidian, Aplidium sp."Tetrahedron Lett. 44. 1243-1245 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] T.Itoh: "Komodoquinone A, a novel neuritogenic anthracycline, from marine Streptomyces sp.KS3"J.Natural Products. 66. 1373-1377 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] T.Itoh: "Stereostructure of Komodoquinone A, a neuritogenic anthracycline, from marine Streptomyces sp.KS3"Chem.Pharm.Bull.. 51. 1402-1404 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] N.Murakami: "New anti-malarial peroxides with in vivo potency derived from spongean metabolites"Biorg.Med.Chem.Lett.. 13. 4081-4084 (2003)

    • Related Report
      2003 Annual Research Report

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Published: 2003-04-01   Modified: 2016-04-21  

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