| Project/Area Number |
15406026
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 海外学術 |
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| Research Field |
Hygiene
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| Research Institution | Nagoya University |
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Principal Investigator |
NASU Tamie Nagoya University, Graduate School of Medicine, Professor, 大学院・医学系研究科, 教授 (10020794)
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| Co-Investigator(Kenkyū-buntansha) |
KAMIJIMA Michihiro Nagoya University, Graduate School of Medicine, Associate Professor, 大学院・医学系研究科, 助教授 (80281070)
ICHIHARA Gaku Nagoya University, Graduate School of Medicine, Associate Professor, 大学院・医学系研究科, 助教授 (90252238)
SHIBATA Eiji Aichi Medical University, School of Medicine, Associated Professor, 医学部, 助教授 (90206128)
王 海蘭 名古屋大学, 大学院・医学系研究科, 外国人特別研究員
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| Project Period (FY) |
2003 – 2005
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| Project Status |
Completed (Fiscal Year 2005)
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| Budget Amount *help |
¥13,300,000 (Direct Cost: ¥13,300,000)
Fiscal Year 2005: ¥4,000,000 (Direct Cost: ¥4,000,000)
Fiscal Year 2004: ¥4,000,000 (Direct Cost: ¥4,000,000)
Fiscal Year 2003: ¥5,300,000 (Direct Cost: ¥5,300,000)
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| Keywords | trichloroethylene / exposure concentrations / severe skin and liver disorders / China / human herpes virus 6 / infectious disease / case-control study / reactivation / 6型ヒトヘルペスウイルス / 抗体価 / 全身性皮膚・肝障害 / 薬剤性過敏性症候群 / HHV-6 / 発熱 / 皮疹 / 脱脂洗浄作業 / アジア諸国 / 肝障害 / 皮膚障害 / 感受性因子 / 尿中代謝物 / 個人曝露量 / 疫学調査 |
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| Research Abstract |
After banning of chlorofluorocarbons and 1,1,1-trichloroethane, various kinds of solvents have been used as substitutes for the above degreasing agents in great demand. As a result, in the developing Asian countries where the rapid industrialization goes far beyond the development of the occupational health system, there have been epidemics of unexpected health disorders (severe skin and liver disorders due to trichloroethylene, TRI) resulting from the introduction of the alternatives. It is notable that TRI, of which the consumed amount dramatically decreased in Japan, is widely used as an alternative solvent in China and has become a cause of this new occupational disease. Especially in Guangdong Province, 208 patients (including 29 fatalities) suffered from the disorders until 2004. While TRI was mainly used as degreaser for metal parts, lens, and semiconductors in the developed countries, there have been only limited number of reports about the disorders. Thus clarifying the mechan
… More
ism and establishing the preventive measures are urgent issues.
We have conducted international collaborative study since 2003 with Hospital for Occupational Diseases Control of Guangdong Province. We investigated TRI exposure levels of the colleague in the company, where the patients worked, by measuring personal exposure levels as well as the urinary metabolites of trichloroethylene. Many workers engaged in their work at higher TRI exposure level than the Occupational Exposure limits in Japan. Many patients with generalized skin reaction were thought to work at the higher exposure levels than the limits in Japan, judging from their urinary metabolites of trichloroethylene.
As for the immunological analysis for the infection by several kinds of virus, there are many patients (14/59) with positive for anti-human herpes virus 6 (HHV6). Interestingly, no positive subjects were seen in the control group. These results suggest that reactivation of HHV6 may be induced in these patients, but the relationship to the development of these diseases are still unknown. Less
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