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Research on the mechanism of generalized skin reaction caused by trichloroethylene exposure

Research Project

Project/Area Number 15406026
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section海外学術
Research Field Hygiene
Research InstitutionNagoya University

Principal Investigator

NASU Tamie  Nagoya University, Graduate School of Medicine, Professor, 大学院・医学系研究科, 教授 (10020794)

Co-Investigator(Kenkyū-buntansha) KAMIJIMA Michihiro  Nagoya University, Graduate School of Medicine, Associate Professor, 大学院・医学系研究科, 助教授 (80281070)
ICHIHARA Gaku  Nagoya University, Graduate School of Medicine, Associate Professor, 大学院・医学系研究科, 助教授 (90252238)
SHIBATA Eiji  Aichi Medical University, School of Medicine, Associated Professor, 医学部, 助教授 (90206128)
王 海蘭  名古屋大学, 大学院・医学系研究科, 外国人特別研究員
Project Period (FY) 2003 – 2005
Project Status Completed (Fiscal Year 2005)
Budget Amount *help
¥13,300,000 (Direct Cost: ¥13,300,000)
Fiscal Year 2005: ¥4,000,000 (Direct Cost: ¥4,000,000)
Fiscal Year 2004: ¥4,000,000 (Direct Cost: ¥4,000,000)
Fiscal Year 2003: ¥5,300,000 (Direct Cost: ¥5,300,000)
Keywordstrichloroethylene / exposure concentrations / severe skin and liver disorders / China / human herpes virus 6 / infectious disease / case-control study / reactivation / 6型ヒトヘルペスウイルス / 抗体価 / 全身性皮膚・肝障害 / 薬剤性過敏性症候群 / HHV-6 / 発熱 / 皮疹 / 脱脂洗浄作業 / アジア諸国 / 肝障害 / 皮膚障害 / 感受性因子 / 尿中代謝物 / 個人曝露量 / 疫学調査
Research Abstract

After banning of chlorofluorocarbons and 1,1,1-trichloroethane, various kinds of solvents have been used as substitutes for the above degreasing agents in great demand. As a result, in the developing Asian countries where the rapid industrialization goes far beyond the development of the occupational health system, there have been epidemics of unexpected health disorders (severe skin and liver disorders due to trichloroethylene, TRI) resulting from the introduction of the alternatives. It is notable that TRI, of which the consumed amount dramatically decreased in Japan, is widely used as an alternative solvent in China and has become a cause of this new occupational disease. Especially in Guangdong Province, 208 patients (including 29 fatalities) suffered from the disorders until 2004. While TRI was mainly used as degreaser for metal parts, lens, and semiconductors in the developed countries, there have been only limited number of reports about the disorders. Thus clarifying the mechan … More ism and establishing the preventive measures are urgent issues.
We have conducted international collaborative study since 2003 with Hospital for Occupational Diseases Control of Guangdong Province. We investigated TRI exposure levels of the colleague in the company, where the patients worked, by measuring personal exposure levels as well as the urinary metabolites of trichloroethylene. Many workers engaged in their work at higher TRI exposure level than the Occupational Exposure limits in Japan. Many patients with generalized skin reaction were thought to work at the higher exposure levels than the limits in Japan, judging from their urinary metabolites of trichloroethylene.
As for the immunological analysis for the infection by several kinds of virus, there are many patients (14/59) with positive for anti-human herpes virus 6 (HHV6). Interestingly, no positive subjects were seen in the control group. These results suggest that reactivation of HHV6 may be induced in these patients, but the relationship to the development of these diseases are still unknown. Less

Report

(4 results)
  • 2005 Annual Research Report   Final Research Report Summary
  • 2004 Annual Research Report
  • 2003 Annual Research Report
  • Research Products

    (17 results)

All 2005 2004 2003 Other

All Journal Article (13 results) Publications (4 results)

  • [Journal Article] トリクロロエチレン作業者に発生する重症皮膚肝障害2005

    • Author(s)
      上島通浩他
    • Journal Title

      産業衛生学雑誌 47

      Pages: 767-767

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Systemic severe skin and liver disorders in workers exposed to trichloroethylene.2005

    • Author(s)
      Kamijima M et al.
    • Journal Title

      J Occup Health 47

      Pages: 767-767

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] トリクロロエチレン作業者に発生する重症皮膚肝障害2005

    • Author(s)
      上島通浩他
    • Journal Title

      産業衛生学雑誌 47・臨時増刊

      Pages: 767-767

    • Related Report
      2005 Annual Research Report
  • [Journal Article] トリクロロエチレン曝露作業者に発生する全身性皮膚・肝障害 第1報 : ウイルス感染の合併2004

    • Author(s)
      黄漢林他
    • Journal Title

      産業衛生学雑誌 46

      Pages: 545-545

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] トリクロロエチレン曝露作業者に発生する全身性皮膚・肝障害 第2報 : 尿中代謝物量2004

    • Author(s)
      上島通浩他
    • Journal Title

      産業衛生学雑誌 46

      Pages: 546-546

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Systemic severe skin and liver disorders in workers exposed to trichloroethylene. 1. Complication with virus infections2004

    • Author(s)
      Huang K et al.
    • Journal Title

      J Occup Health 46

      Pages: 545-545

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Systemic severe skin and liver disorders in workers exposed to trichloroethylene. 2. Urinary metabolites2004

    • Author(s)
      Kamijima M et al.
    • Journal Title

      J Occup Health 46

      Pages: 546-546

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Generalized skin reactions in relation to trichloroethylene exposure : A review from the viewpoint of drug-metabolizing enzymes2003

    • Author(s)
      Nakajima et al.
    • Journal Title

      J Occup Health 45

      Pages: 8-14

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] トリクロロエチレン作業者に発生する全身性皮膚・肝障害 第1報 : 患者発生作業状況の調査2003

    • Author(s)
      王 海蘭他
    • Journal Title

      産業衛生学雑誌 45

      Pages: 562-562

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] トリクロロエチレン作業者に発生する全身性皮膚・肝障害 第2報 : 作業中の自覚症状と尿中代謝物量2003

    • Author(s)
      上島通浩他
    • Journal Title

      産業衛生学雑誌 45

      Pages: 563-563

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Generalized skin reactions in relation to trichloroethylene exposure : A review from the drug-metabolizing enzymes2003

    • Author(s)
      Nakajima T, Yamanoshita O, Kamijima M, Kishi R, Ichihara G.
    • Journal Title

      J Occup Health 45

      Pages: 8-14

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Systemic severe skin and liver disorders in workers exposed to trichloroethylene. 1. Working status of the patients with severe skin and liver disorders2003

    • Author(s)
      Wang H, et al.
    • Journal Title

      J Occup Health 45

      Pages: 562-562

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Systemic severe skin and liver disorders in workers exposed to trichloroethylene. 2. Relationship between the symptoms and urinary metabolites of trichloroethylene.2003

    • Author(s)
      Kamijima M et al.
    • Journal Title

      J Occup Health 45

      Pages: 563-563

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Publications] Nakajima T, Yamanosita O, Kamijima M, Kishi R, Ichihara G: "Generalized skin reactions in relation to trichloroethylene exposure : a review from the viewpoint of drug-metabolizing enzymes"J Occup Health. 45(1). 8-14 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] 上島通浩, 柴田英治: "有機溶剤中毒の最近の話題"日本医事新報. 4148. 33-36 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] 那須民江他: "環境化学物質の代謝とその周辺"日本公衆衛生協会. 362 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] 分子予防環境医学編(那須民江他): "分子予防環境医学"本の泉社. 768 (2003)

    • Related Report
      2003 Annual Research Report

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Published: 2003-04-01   Modified: 2016-04-21  

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