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Carcinogenic risk assessment of arsenic poisoning in Bangladesh and ingestion of organo-arsenic in Japan.

Research Project

Project/Area Number 15406029
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section海外学術
Research Field Hygiene
Research InstitutionOsaka City University

Principal Investigator

ENDO Ginji  Osaka City University, Graduate School of Medicine, professor, 大学院医学研究科, 教授 (20160393)

Co-Investigator(Kenkyū-buntansha) WANIBUCHI Hideki  Osaka City University, Graduate School of Medicine, associate professor, 大学院医学研究科, 助教授 (90220970)
KITAMURA Mari  Mukogawa Women's University, Faculty of life environment, lecturer, 生活環境学部・食物栄養学科, 講師 (40369666)
HAYASHI Tomoshige  Osaka City University, Graduate School of Medicine, associate professor, 大学院医学研究科, 助教授 (10381980)
吉田 香  甲子園大学, 栄養学部, 助教授 (10336787)
黒田 孝一  大阪市立大学, 大学院・医学研究科, 助教授 (30158886)
Project Period (FY) 2003 – 2005
Project Status Completed (Fiscal Year 2005)
Budget Amount *help
¥13,300,000 (Direct Cost: ¥13,300,000)
Fiscal Year 2005: ¥3,900,000 (Direct Cost: ¥3,900,000)
Fiscal Year 2004: ¥4,100,000 (Direct Cost: ¥4,100,000)
Fiscal Year 2003: ¥5,300,000 (Direct Cost: ¥5,300,000)
Keywordsarsenic / well water / organoarsenic / environmental pollution / Bangladesh / food / risk assessment / carcinogenicity / 生物学的モニタリング / 誘導結合プラズマ質量分析装置 / 粒子線励起X線 / ジメチルアルシン酸 / 発がんリスク評価
Research Abstract

The purpose of this study was to examine the association between current arsenic level of well water and urinary arsenic concentration to examine the effectiveness of Bangladeshi mitigation programs. A community-based cross-sectional study was conducted in the Pabna district of Bangladesh between May and July 2005. We included 174 married couples and collected their drinking water from 138 wells. Of 326 subjects, 304 cases exceeded urinary arsenic level of 40μg/1.5L/day. Of all wells, 23.1% wells had arsenic level >50 μg/L. Multiple-adjusted odds ratio of urinary arsenic level >40μg/1.5L/day were 8.90 (95% CI : 3.31-23.93) for arsenic level of well water of 11-50 μg/L and 53.07 (11.91-236.46) for that of 51.332 μg/L as compared with that of 【less than or equal】10 μg/L. These results suggest that arsenic level of well water of 11.50 μg/L that Bangladesh government regarded as safe were not safe.
We performed speciation analysis of urinary arsenic for 210 Japanese male subjects without occupational exposure using HPLC-ICP-MS. The median values of urinary arsenics were as follows : sodium arsenite (AsIII),3.5 ; sodium arsenate (AsV), 0.1 ; monomethylarsonic acid (MMA), 3.1 ; dimethylarsinic acid (DMA), 42.6 ; arsenobetaine (AsBe), 61.3 ; arsenocholine, trimethylarsine oxide, and unidentified arsenics (others), 5.2 ; and total arsenic (total As), 141.3 μgAs/1. It appears that the high levels of DMA and AsBe observed in Japan may be due in part to seafood intake.
To clarify the risks of Hijiki ingestion, a 42-year-old male volunteer ingested 825 μg of iAs compounds contained in eight servings of commercial Hijiki food, after refraining from eating seafood for 3 months. The total amounts of AsV, AsIII, MMA and DMA excreted in urine over 50 h were 11.2, 31.8, 40.9 and 104.0 μg, respectively. Long-term ingestion of Hijiki might thus have the potential to cause arsenic poisoning.

Report

(4 results)
  • 2005 Annual Research Report   Final Research Report Summary
  • 2004 Annual Research Report
  • 2003 Annual Research Report
  • Research Products

    (47 results)

All 2007 2006 2005 2004 2003 Other

All Journal Article (40 results) Book (1 results) Publications (6 results)

  • [Journal Article] HPLC-ICP-MS speciation analysis of arsenic in urine of Japanese subjects without occupational exposure.2007

    • Author(s)
      Hata A, Endo Y, Nakajima Y, Ikebe M, Ogawa M, Fujitani N, Endo G
    • Journal Title

      J Occup Health 49(in press)

    • NAID

      110006278716

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] HPLC-ICP-MS speciation analysis of arsenic in urine of Japanese subjects without occupational exposure.2007

    • Author(s)
      Hata A, Endo Y, Nakajima Y, Ikebe M, Ogaw a M, Fujitani N, Endo G
    • Journal Title

      J Occup Health 49 (in press)

    • NAID

      110006278716

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Ingestion of Hijiki seaweed and risk of arsenic poisoning.2006

    • Author(s)
      Nakajima Y, Endo Y, Inoue Y, Yamanaka K, Kato K, Wanibuchi H, Endo G
    • Journal Title

      Appl Organomet Chem 20

      Pages: 557-564

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] 化学兵器処理作業者のバイオロジカルモニタリング2006

    • Author(s)
      中嶋義明, 圓藤吟史, 井上嘉則, 雪田清廣, 圓藤陽子
    • Journal Title

      日職災医誌 54

      Pages: 29-33

    • NAID

      10024572122

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] A comparative study of the sub-chronic toxic effects of three organic arsenical compounds on the urothelium in F344 rats; gender-based differences in response.2006

    • Author(s)
      Shen J, Wanibuchi H, Waalkes MP, Salim EI, Kinoshita A, Yoshida K, Endo G, Fukushima S
    • Journal Title

      Toxicol Appl Pharmacol. 210(3)

      Pages: 171-180

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Ingestion of Hijiki seaweed and risk of arsenic poisoning.2006

    • Author(s)
      Nakajima Y, Endo Y, Inoue Y, Yamanaka K, Kato K, Wanibuchi H, Endo G
    • Journal Title

      Appl Organomet Chem. 20

      Pages: 557-564

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] A comparative study of the sub-chronic toxic effects of three organic arsenical compounds on the urothelium in F344 rats; gender-based differences in response.2006

    • Author(s)
      Shen J, Wanibuchi H, Waalkes MP, Salim EI, Kinoshita A, Yoshida K, Endo G, Fukushima S.
    • Journal Title

      Toxicol Appl Pharmacol. 1;210(3)

      Pages: 171-80

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Biological monitoring of the workers engaged in the disposal of chemical weapons2006

    • Author(s)
      Nakajima Y, Endo G, Inoue Y, Yukita K, Endo Y
    • Journal Title

      Japanese Journal of Occupational Medicine and Traumatology 54

      Pages: 29-33

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] 非職業性ヒ素曝露者における形態別尿中ヒ素濃度の調査2006

    • Author(s)
      畑明寿, 中嶋義明, 池部麻衣子, 圓藤陽子, 北村真理, 藤谷登, 圓藤吟史
    • Journal Title

      日本衛生学雑誌 61(2)

      Pages: 299-299

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Genotoxicity of dimethylarsinous acid : high induction of tetraploids.2005

    • Author(s)
      Kuroda K, Yoshida K, Yoshimura M, Endo Y, Wanibuchi H, Fukushima S, Endo G
    • Journal Title

      Appl Organomet Chem 19(2)

      Pages: 221-225

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] 海産物のヒ素-その健康リスク.2005

    • Author(s)
      圓藤吟史, 中嶋義明, 圓藤陽子
    • Journal Title

      医学のあゆみ 212(9)

      Pages: 846-847

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Genotoxicity of dimethylarsinous acid : high induction of tetraploids.2005

    • Author(s)
      Kuroda K, Yoshida K, Yoshimura M, Endo Y, Wanibuchi H, Fukushima S, Endo G
    • Journal Title

      Appl Organomet Chem 19 (2)

      Pages: 221-225

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Arsenic in seafood-the health risk2005

    • Author(s)
      Endo G, Nakajima Y, Endo Y
    • Journal Title

      Igaku no Ayumi. 212 (9)

      Pages: 846-847

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Red and Green marked well still awareness in arsenic polluted area in Bangladesh2005

    • Author(s)
      Md.Ahsan Habib, Hayashi T, Hata A, Ikebe M, F Rarman, Endo G.
    • Journal Title

      ヒ素シンポジウム講演要旨集 12

      Pages: 84-85

    • Related Report
      2005 Annual Research Report
  • [Journal Article] 海産物のヒ素-その健康リスク2005

    • Author(s)
      圓藤吟史, 中嶋義明, 圓藤陽子
    • Journal Title

      医学のあゆみ 212(9)

      Pages: 846-847

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Diphenylarsinic acid poisoning from chemical weapons in Kamisu, Japan.2004

    • Author(s)
      Ishii K, Tamaoka A, Otsuka F, Iwasaki N, Shin K, Matsui A, Endo G, Kumagai Y, Ishii T, Shoji S, Ogata T, Ishizaki M, Doi M, Shimojo N
    • Journal Title

      Ann Neurol. 56(5)

      Pages: 741-745

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Microbial metabolite of dimethylarsinic acid is highly toxic and genotoxic.2004

    • Author(s)
      Kuroda K, Yoshida K, Yoshimura M, Endo Y, Wanibuchi H, Fukushima S, Endo G
    • Journal Title

      Toxicol Appl Pharmacol. 198(3)

      Pages: 345-353

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Understanding arsenic carcinogenicity by the use of animal models.2004

    • Author(s)
      Wanibuchi H, Salim EI, Kinoshita A, Shen J, Wei M, Morimura K, Yoshida K, Kuroda K, Endo G, Fukushima S
    • Journal Title

      Toxicol Appl Pharmacol. 198(3)

      Pages: 366-376

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Determination of trivalent methylated arsenicals in rat urine by liquid chromatography-inductively coupled plasma mass spectrometry after solvent extraction.2004

    • Author(s)
      Okina M, Yoshida K, Kuroda K, Wanibuchi H, Fukushima S, Endo G
    • Journal Title

      J Chromatogr B Analyt Technol Biomed Life Sci. 799(2)

      Pages: 209-215

    • NAID

      10016546419

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] 食餌中のシステインおよび腸内細菌がヒ素の代謝に与える影響.2004

    • Author(s)
      吉田香, 翁昌子, 北村真理, 周栩, 鰐渕英機, 圓藤吟史, 黒田孝一
    • Journal Title

      生活衛生 48

      Pages: 407-414

    • NAID

      130004809609

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Diphenylarsinic acid poisoning from chemical weapons in Kamisu, Japan.2004

    • Author(s)
      Ishii K, Tamaoka A, Otsuka F, Iwasaki N, Shin K, Matsui A, Endo G, Kumagai Y, Ishii T, Shoji S, Ogata T, Ishizaki M, Doi M, Shimojo N.
    • Journal Title

      Ann Neurol. 56(5)

      Pages: 741-5

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Microbial metabolite of dimethylarsinic acid is highly toxic and genotoxic.2004

    • Author(s)
      Kuroda K, Yoshida K, Yoshimura M, Endo Y, Wanibuchi H, Fukushima S, Endo G.
    • Journal Title

      Toxicol Appl Pharmacol. 1; 198(3)

      Pages: 345-53

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Understanding arsenic carcinogenicity by the use of animal models.2004

    • Author(s)
      Wanibuchi H, Salim EI, Kinoshita A, Shen J, Wei M, Morimura K, Yoshida K, Kuroda K, Endo G, Fukushima S.
    • Journal Title

      Toxicol Appl Pharmacol. 1; 198(3)

      Pages: 366-76

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Determination of trivalent methylated arsenicals in rat urine by liquid chromatography-inductively coupled plasma mass spectrometry after solvent extraction.2004

    • Author(s)
      Okina M, Yoshida K, Kuroda K, Wanibuchi H, Fukushima S, Endo G.
    • Journal Title

      J Chromatogr B Analyt Technol Biomed Life Sci. 25; 799(2)

      Pages: 209-15

    • NAID

      10016546419

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Effects of dietary cysteine and entromicroorganisms on metabolism of arsenic.2004

    • Author(s)
      Yoshida K, Okina S, Kitamura M, Zhou X, Wanibuchi H, Endo G, Kuroda, K
    • Journal Title

      Seikatsu Eisei 48

      Pages: 407-414

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Determination of trivalent methylated arsenicals in rat urine by liquid chromatography-inductively coupled plasma mass spectrometry after solvent extraction2004

    • Author(s)
      Okina M, Yoshida K, Kuroda K, Wanibuchi H, Fukushima S, Endo G.
    • Journal Title

      J Chromatogr B 799(2)

      Pages: 209-215

    • NAID

      10016546419

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Microbial metabolite of dimethylarsinic acid is highly toxic and genotoxic2004

    • Author(s)
      Kuroda K, Yoshida K, Yoshimura M, Endo Y, Wanibuchi H, Fukushima S, Endo G
    • Journal Title

      Toxicol Appl Pharmacol. 198(3)

      Pages: 345-353

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Understanding arsenic carcinogenicity by the use of animal models2004

    • Author(s)
      Wanibuchi H, Salim EI, Kinoshita A, Shen J, Wei M, Morimura K, Yoshida K, Kuroda K, Endo G, Fukushima S.
    • Journal Title

      Toxicol Appl Pharmacol 198(3)

      Pages: 366-376

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Genotoxicity of dimethylarsinous acid : high induction of tetraploids.2004

    • Author(s)
      Kuroda K, Yoshida K, Yoshimura M, Endo Y, Wanibuchi H, Fukushima S, Endo G
    • Journal Title

      Appl.Organomet.Chem. 19

      Pages: 221-225

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Induction of glutathione S-transferase placental form positive foci in liver and epithelial hyperplasia in urinary bladder, but no tumor development in male Fischer 344 rats treated with monomethylarsonic acid for 104 weeks.2003

    • Author(s)
      Shen J, Wanibuchi H, Salim EI, Wei M, Doi K, Yoshida K, Endo G, Morimura K, Fukushima S
    • Journal Title

      Toxicol Appl Pharmacol. 193(3)

      Pages: 335-345

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Liver tumorigenicity of trimethylarsine oxide in male Fischer 344 rats-association with oxidative DNA damage and enhanced cell proliferation.2003

    • Author(s)
      Shen J, Wanibuchi H, Salim EI, Wei M, Kinoshita A, Yoshida K, Endo G, Fukushima S
    • Journal Title

      Carcinogenesis. 24(11)

      Pages: 1827-1835

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Urinary sulfur-containing metabolite produced by intestinal bacteria following oral administration of dimethylarsinic acid to rats.2003

    • Author(s)
      Yoshida K, Kuroda K, Zhou X, Inoue Y, Date Y, Wanibuchi H, Fukushima S, Endo G
    • Journal Title

      Chem Res Toxicol. 16(9)

      Pages: 1124-1129

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Effects of cysteine on the cytotoxicity of arsenic compounds.2003

    • Author(s)
      Zhou X, Yoshida K, Kuroda K, Endo Y, Endo G
    • Journal Title

      Arch Environ Contam Toxicol. 45(3)

      Pages: 324-330

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Carcinogenicity of dimethylarsinic acid in p53 heterozygous knockout and wild-type C57BL/6J mice.2003

    • Author(s)
      Salim EI, Wanibuchi H, Morimura K, Wei M, Mitsuhashi M, Yoshida K, Endo G, Fukushima S
    • Journal Title

      Carcinogenesis 24(2)

      Pages: 335-342

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Induction of glutathione S-transferase placental form positive foci in liver and epithelial hyperplasia in urinary bladder, but no tumor development in male Fischer 344 rats treated with monomethylarsonic acid for 104 weeks.2003

    • Author(s)
      Shen J, Wanibuchi H, Salim EI, Wei M, Doi K, Yoshida K, Endo G, Morimura K, Fukushima S.
    • Journal Title

      Toxicol Appl Pharmacol. 15; 193(3)

      Pages: 335-45

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Liver tumorigenicity of trimethylarsine oxide in male Fischer 344 rats-association with oxidative DNA damage and enhanced cell proliferation.2003

    • Author(s)
      Shen J, Wanibuchi H, Salim EI, Wei M, Kinoshita A Yoshida K, Endo G, Fukushima S.
    • Journal Title

      Carcinogenesis 24(11)

      Pages: 1827-35

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Urinary sulfur-containing metabolite produced by intestinal bacteria following oral administration of dimethylarsinic acid to rats.2003

    • Author(s)
      Yoshida K, Kuroda K, Zhou X, Inoue Y, Date Y, Wanibuchi H, Fukushima S, Endo G.
    • Journal Title

      Chem Res Toxicol. 16(9)

      Pages: 1124-9

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Effects of cysteine on the cytotoxicity of arsenic compounds.2003

    • Author(s)
      Zhou X, Yoshida K, Kuroda K, Endo Y, Endo G.
    • Journal Title

      Arch Environ Contam Toxicol. 45(3)

      Pages: 324-30

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Carcinogenicity o dimethylarsinic acid in p53 heterozygous knockout and wild-type C57BL/6J mice.2003

    • Author(s)
      Salim EI, Wanibuchi H, Morimura K, Wei M, Mitsuhashi M, Yoshida K, Endo G, Fukushima S.
    • Journal Title

      Carcinogenesis. 24(2)

      Pages: 335-42

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Heavy metals pollution-arsenic2003

    • Author(s)
      Endo G
    • Journal Title

      The Proceeding of 26^<th> General Assembly of the Japan Medical Congress.

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Book] 第26回日本医学会総会会誌2003

    • Author(s)
      圓藤 吟史
    • Publisher
      重金属汚染-ヒ素.
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Publications] Zhou, X., Yoshida, K., Kuroda, K., Endo, Y., Endo, G.: "Effects of cysteine on the cytotoxicity of arsenic compounds"Arch.Environ.Contam.Toxcol.. 45. 324-330 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Yoshida, K., Kuroda, K., Zhou, X., Inoue, Y., Date, Y., Wanibuchi, H., Fukushima, S., Endo, G.: "Urinary sulfur-containing metabolite produced by intestinal bacteria following oral administration of dimethylarsinic acid to rats"Chem.Res.Texicol.. 16・9. 1124-1129 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] 圓藤 吟史: "重金属汚染-ヒ素"第26回日本医学会総会会誌. (In press). (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] "ジフェニルアルシン化合物の毒性(日本ヒ素研究会)"Arsenic Letter. No.8. 8-13 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] 圓藤 吟史: "重金属汚染-ヒ素"第26回日本医学会総会会誌. (In press). (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] "ジフェニルアルシン化合物の毒性"Arsenic Letter(日本ヒ素研究会). No.8. 8-13 (2003)

    • Related Report
      2003 Annual Research Report

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Published: 2003-04-01   Modified: 2016-04-21  

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