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Clinical and epidemiological study on the endemic neurodegenerative diseases (parkinsonism-dementia complex : PDC) in the Kii peninsula of Japan, Guam island and Guadeloupe, French west Indies.

Research Project

Project/Area Number 15406034
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section海外学術
Research Field Neurology
Research InstitutionMie University

Principal Investigator

KUZUHARA Shigeki  Mie University, Graduate School of Medicine, Neurology, Professor, 大学院・医学系研究科, 教授 (70111383)

Co-Investigator(Kenkyū-buntansha) NARITA Yugo  Mie University Hospital, Neurology, Associate Professor, 医学部附属病院, 助教授 (50242954)
KOKUBO Yasumasa  Mie University, Graduate School of Medicine, Neurology, Assistant Professor, 大学院・医学系研究科, 助手 (60263000)
Project Period (FY) 2003 – 2005
Project Status Completed (Fiscal Year 2005)
Budget Amount *help
¥9,700,000 (Direct Cost: ¥9,700,000)
Fiscal Year 2005: ¥2,800,000 (Direct Cost: ¥2,800,000)
Fiscal Year 2004: ¥2,800,000 (Direct Cost: ¥2,800,000)
Fiscal Year 2003: ¥4,100,000 (Direct Cost: ¥4,100,000)
KeywordsALS / PDC / Neurological Intractable Disease / Food / Environment / Parkinsonism / Dementia / 認知症
Research Abstract

In 2004 and 2005 we visited Guadeloupe, and examined 17 atypical Caribbean parkinsonism patients with a cooperation of professor Lannuzel, Guadeloupe University Hospital, and have found they were characterized by akinesia and frontal abulia without obvious rigidity, tremor, freezing, and seemed to be a different entity from PDC on Guam and Kii peninsula. Fruit and herb tea of Annona which are suspected as its cause are not consumed in Japan. We were invited to the "Neurodegenerative disorders on Guam and in the Pacific regions symposium" held on December 2-5, 2005, and talked on ALS-PDC in the Kii peninsula: clinical, neuropathological and epidemiological studies. Similarities and differences between Guamanian and Kii diseases and possible causes were discussed. PDC on Guam and PDC in Kii may be included in an entity.

Report

(4 results)
  • 2005 Annual Research Report   Final Research Report Summary
  • 2004 Annual Research Report
  • 2003 Annual Research Report
  • Research Products

    (19 results)

All 2006 2005 2004 2003

All Journal Article (17 results) Book (2 results)

  • [Journal Article] 紀伊半島の筋萎縮性側索硬化症/パーキンソン痴呆複合症例脳のα-synuclein陽性構造の免疫組織学的検討2006

    • Author(s)
      谷口 彰, 小久保康昌, 葛原茂樹, 村山繁雄
    • Journal Title

      厚生労働科学研究費補助金難治性疾患克服研究事業 神経変性疾患に関する調査研究班 (主任研究者・葛原茂樹) 2005年度研究報告書

      Pages: 128-131

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] 前頭側頭型痴呆2006

    • Author(s)
      葛原茂樹
    • Journal Title

      Annual Review2006神経

      Pages: 188-197

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Atypical parkinsonism of Japan : amyotrophic lateral sclerosis-parkinsonism-dementia complex of the Kii peninsula of Japan (Muro disease) : An update2005

    • Author(s)
      Kuzuhara S, Kokubo Y
    • Journal Title

      Movement Disorders 20 (Suppl. 12)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] 運動ニューロン疾患を伴う痴呆症 紀伊半島のALS/PDC2005

    • Author(s)
      葛原茂樹
    • Journal Title

      Clinical Neuroscience 23

      Pages: 317-319

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Annual Research Report 2005 Final Research Report Summary
  • [Journal Article] 筋萎縮性側索硬化症・パーキンソン痴呆複合(ALS/PDC)の臨床遺伝学と病理2005

    • Author(s)
      葛原茂樹
    • Journal Title

      Cognition and Dementia 4

      Pages: 274-281

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Annual Research Report 2005 Final Research Report Summary
  • [Journal Article] 紀伊半島の筋萎縮性側索硬化症/パーキンソン痴呆複合に出現するpigmentary retinopathy2005

    • Author(s)
      小久保康昌, 伊藤邦生, 葛原茂樹
    • Journal Title

      厚生労働科学研究費補助金難治性疾患克服研究事業 神経変性疾患に関する調査研究班 (主任研究者・葛原茂樹) 2004年度研究報告書

      Pages: 80-82

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Atypical parkinsonism of Japan : amyotrophic lateral sclerosis-parkinsonism-dementia complex of the Kii peninsula of Japan (Muro disease) : An update2005

    • Author(s)
      Kuzuhara S, Kokubo Y
    • Journal Title

      Mov Disord 20(Suppl.12)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Clinical genetics and neuropathology of amyotrophic lateral sclerosis/parkinsonism-dementia complex (ALS/PDC)2005

    • Author(s)
      Kuzuhara S
    • Journal Title

      Cognition and Dementia 4

      Pages: 274-281

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Atypical parkinsonism of Japan : amyotrophic lateral sclerosis-parkinsonism-dementia complex of the Kii peninsula of Japan (Muro disease) : an update.2005

    • Author(s)
      Shigeki Kuzuhara, Yasumasa Kokubo
    • Journal Title

      Movement Disorders 20, Supple 12

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Neurofibrillary tangles of residents in ALS and parkinsonism-dementia complex focus in Japan2004

    • Author(s)
      Kokubo Y
    • Journal Title

      Neurology

      Pages: 2399-2401

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Neurofibrillary tangles of residents in ALS and parkinsonism-dementia complex focus in Japan2004

    • Author(s)
      Kokubo Y
    • Journal Title

      Neurology (In press)

    • Related Report
      2003 Annual Research Report
  • [Journal Article] Ophthalmomyiasis-like pigmentary retinopathy in ALS/PDC in the Kii peninsula of Japan.2003

    • Author(s)
      Kokubo Y
    • Journal Title

      Neurology 60

      Pages: 1725-1726

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Neuroradiological study on amyotrophic lateral sclerosis and parkinsonism-dementia complex in the Kii peninsula of Japan2003

    • Author(s)
      Kokubo Y
    • Journal Title

      Arch Neurol. 60

      Pages: 1257-1261

    • Related Report
      2004 Annual Research Report 2003 Annual Research Report
  • [Journal Article] Biochemical and ultrastructural study on neurofibrillary tangles of ALS/PDC cases in the Kii peninsula of Japan2003

    • Author(s)
      Ito N
    • Journal Title

      JNEN 62

      Pages: 791-798

    • Related Report
      2004 Annual Research Report 2003 Annual Research Report
  • [Journal Article] Somatosensory evoked potential recovery in Kii amyotrophic lateral sclerosis/parkinsonism dementia complex(Kii ALS/PDC).2003

    • Author(s)
      Machii K
    • Journal Title

      Clin Neurophysiol 114(In press)

      Pages: 564-568

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Ophthalmomyiasis-like pigmentary retinopathy in ALS/PDC in the Kii peninsula of Japan2003

    • Author(s)
      Kokubo Y
    • Journal Title

      Neurology 60

      Pages: 1725-1726

    • Related Report
      2003 Annual Research Report
  • [Journal Article] Somatosensory evoked potential recovery in Kii amyotrophic lateral sclerosis/parkinsonism dementia complex (Kii ALS/PDC).2003

    • Author(s)
      Machii K
    • Journal Title

      Clin Neurophysiol 114(In press)

      Pages: 564-568

    • Related Report
      2003 Annual Research Report
  • [Book] Annual Review 神経・2006 (柳澤信夫, 篠原幸人, 岩田 誠, 清水輝夫, 寺本 明 編集)、「前頭側頭型痴呆 (p188-197)」2006

    • Author(s)
      葛原茂樹
    • Total Pages
      378
    • Publisher
      中外医学社
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Book] Annual Review 神経 2004 (柳澤信夫, 篠原幸人, 岩田 誠, 清水輝夫, 寺本 明 編集)、「ALS/parkinsonism-dementiaの現状 (p189-197)」2004

    • Author(s)
      葛原茂樹
    • Total Pages
      366
    • Publisher
      中外医学社
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary

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Published: 2003-04-01   Modified: 2016-04-21  

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