| Project/Area Number |
15500197
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Bioinformatics/Life informatics
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| Research Institution | Kobe University (2005)
Osaka University (2003-2004) |
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Principal Investigator |
OHKAWA Takenao Kobe University, Graduate School of Science and Technology, Professor, 自然科学研究科, 教授 (30223738)
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| Co-Investigator(Kenkyū-buntansha) |
OZAKI Tomonobu Kobe University, Graduate School of Science and Technology, Research Associate, 自然科学研究科, 助手 (40365458)
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| Project Period (FY) |
2003 – 2005
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| Project Status |
Completed (Fiscal Year 2005)
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| Budget Amount *help |
¥3,700,000 (Direct Cost: ¥3,700,000)
Fiscal Year 2005: ¥800,000 (Direct Cost: ¥800,000)
Fiscal Year 2004: ¥1,400,000 (Direct Cost: ¥1,400,000)
Fiscal Year 2003: ¥1,500,000 (Direct Cost: ¥1,500,000)
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| Keywords | Bioinformatics / Protein / Structure data / Functional information extraction / Profile / Retrieval system / Text mining / Data mining / 立体構造 / 表面モチーフ / 分子表面 / データベース / フィルタリング |
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| Research Abstract |
We have developed some methods of assisting knowledge discovery from protein structure database, which include three-dimensional data processing, structure data mining, text mining, and information filtering for protein functional analysis.
1. Profile extraction from protein structure data and its application to retrieval of protein with similar interaction
Since function of a protein depends on the interaction in its local site, a profile is automatically generated from information of location and properties of atoms in the interaction sites of proteins with the same interaction. Profile-based retrieval method has also been explored, in which the pattern matching between generated profile and protein structure data is introduced.
2. Surface motif discovery from protein surface data
A method of mining protein molecular surface database for extracting surface motifs, which are patterns of shape and physical properties that commonly appear in protein molecular surfaces, has been proposed. We also have proposed a method of filtering surface motifs by using TF-IDF evaluation and negative instances of interaction sites.
3. Protein functional information extraction from literature by using structure data
A method of extracting protein functional information from literature related to protein structure analysis has been proposed. In this method, interaction-related sentences are selected by using distance between protein and its partner based on structure data, and then, functional information is extracted by text processing and iterative learning using feedback information from the operator.
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