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Control mechanism of midbrain dopaminergic neurons by the limbic system.

Research Project

Project/Area Number 15500238
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Nerve anatomy/Neuropathology
Research InstitutionShimane University (2004)
Shimane Medical University (2003)

Principal Investigator

YASUI Yukihiko  Shimane Univ., Dept.of Anatomy, Professor, 医学部, 教授 (30174501)

Co-Investigator(Kenkyū-buntansha) TSUMORI Toshiko  Shimane Univ., Dept.of Anatomy, Assistant Prof., 医学部, 助手 (30217377)
Project Period (FY) 2003 – 2004
Project Status Completed (Fiscal Year 2004)
Budget Amount *help
¥3,700,000 (Direct Cost: ¥3,700,000)
Fiscal Year 2004: ¥1,300,000 (Direct Cost: ¥1,300,000)
Fiscal Year 2003: ¥2,400,000 (Direct Cost: ¥2,400,000)
Keywordslimbic system / infralimbic cortex / amygdaloid body / retrorubral field / ventral tegmental area / dopaminergic neuron / synapse / rat / 扁桃体中心核 / チロシン水酸化酵素 / ビオチン化デキスランアミン
Research Abstract

We examined the synaptic organization between the amygdaloid fibers and the tyrosine hydroxylase(TH)-immunoreactive(TH-ir) neurons in the midbrain by using anterograde tracing combined with immunohistochemistry for TH, which catalyzes the rate-limiting step in the synthesis of catecholamines.
After biotinylated dextranamine(BDA) injection into the central amygdaloid nucleus, many BDA-labeled fibers and axon terminals were distributed in the retrorubral field(RRF). Some labeled fibers were also found in the lateral part of the substantia nigra pars compacta(SNc) although there were only a few labeled fibers in the ventral tegmental area(VTA). TH-like immunoreactive(THir) neurons were distributed in the RRA,SNc and VTA. The good overlapping distribution of these labeled axons and neurons was found in the RRF. Within the RRF,BDA-labeled axons made symmetrical synaptic contacts with the dendrites and somata of TH-ir neurons.
After BDA injection into the infralimbic cortex(ILC, many BDA-labeled fibers and axon terminals were distributed in the VTA and medialmost part of the SNc., where TH-ir neurons were embedded in the plexus of BDA-labeled axons. Within the VTA,BDA-labeled axons made asymmetrical synaptic contacts with the dendrites of TH-ir neurons.
The data suggest that dopaminergic neurons in the RRF and VTA receive inhibitory inputs from the ACe and excitatory inputs from the ILC, respectively.

Report

(3 results)
  • 2004 Annual Research Report   Final Research Report Summary
  • 2003 Annual Research Report
  • Research Products

    (14 results)

All 2004 2003 Other

All Journal Article (12 results) Publications (2 results)

  • [Journal Article] Glutamatergic pathways from the Kolliker-Fuse nucleus to the phrenic nucleus in the rat.2004

    • Author(s)
      Shigefumi Yokota et al.
    • Journal Title

      Brain Research 995

      Pages: 118-130

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Amygdaloid axon terminals are in contact with trigeminal premotor neurons in the parvicellular reticular formation of the rat medulla oblongata.2004

    • Author(s)
      Yukihiko Yasui et al.
    • Journal Title

      Brain Research 1016

      Pages: 129-134

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Glutamatergic pathways from the Kolliker-Fuse nucleus to the phrenic nucleus in the rat.2004

    • Author(s)
      Shigefumi Yokota et al.
    • Journal Title

      Brain Research 995(1)

      Pages: 118-130

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Amygdaloid axon terminals are in contact with trigeminal premotor neurons in the parvicellular reticular formation of the rat medulla oblongata.2004

    • Author(s)
      Yukihiko Yasui et al.
    • Journal Title

      Brain Research 1016(1)

      Pages: 129-134

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Glutamatergic pathways from the Kolliker-Fuse nucleus to the phrenic nucleus in the rat.2004

    • Author(s)
      Shigefumi Yokota
    • Journal Title

      Brain Research 995・1

      Pages: 118-130

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Amygdaloid axon terminals are in contact with trigeminal premotor neurons in the parvicellular reticular formation of the rat medulla oblongata.2004

    • Author(s)
      Yukihiko Yasui
    • Journal Title

      Brain Research 1016・1

      Pages: 129-134

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Synaptic organization between the cortical or amygdaloid fibers and the lateral hypothalamic neurons in the rat.2004

    • Author(s)
      Toshiko Tsumori
    • Journal Title

      Anatomical Science International 79・Suppl.

      Pages: 378-378

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Nigrothalamostriatal and nigrothalamocortical pathways via the ventrolateral parafascicular nucleus.2003

    • Author(s)
      Toshiko Tsumori et al.
    • Journal Title

      NeuroReport 14

      Pages: 81-86

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Comparative neurotoxicity of intrathecal and epidural lidocaine in rats.2003

    • Author(s)
      Yumiko Kirihara et al.
    • Journal Title

      Anesthesiology 99

      Pages: 961-968

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] 多重標識法による神経回路の解析2003

    • Author(s)
      安井幸彦
    • Journal Title

      電子顕微鏡 38

      Pages: 198-201

    • NAID

      10012563230

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Nigrothalamostriatal and nigrothalamocortical pathways via the ventrolateral parafascicular nucleus.2003

    • Author(s)
      Toshiko Tsumori et al.
    • Journal Title

      Neuro Report 14(1)

      Pages: 81-86

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Comparative neurotoxicity of intrathecal and epidural lidocaine in rats.2003

    • Author(s)
      Yumiko Kirihara et al.
    • Journal Title

      Anesthesiology 99(4)

      Pages: 961-968

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Publications] Shigefumi Yokota et al.: "Glutamatergic pathways from the Kolliker-Fuse nucleus to the phrenic nucleus in the rat"Brain Research. 995. 118-130 (2004)

    • Related Report
      2003 Annual Research Report
  • [Publications] Toshiko Tsumori et al.: "Cortical and amygdaloid fibers are in synaptic contact with the autonomic neurons in the lateral hypothalamus of the rat"Acta Anatomic Nipponica. 78, Suppl. 221 (2003)

    • Related Report
      2003 Annual Research Report

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Published: 2003-04-01   Modified: 2016-04-21  

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