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Analysis of development and remodeling of neural circuit related to the visceral reflexes in the medulla and spinal cord

Research Project

Project/Area Number 15500244
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Nerve anatomy/Neuropathology
Research InstitutionYokohama City University

Principal Investigator

FUNAKOSHI Kengo  Yokohama City University School of Medicine, Professor, 医学研究科, 教授 (60291572)

Co-Investigator(Kenkyū-buntansha) ATOBE Yoshitoshi  Yokohama City University School of Medicine, Assistant professor, 医学研究科, 助手 (60264602)
NAKANO Masato  Yokohama City University School of Medicine, Assistant professor, 医学研究科, 助手 (50237351)
Project Period (FY) 2003 – 2005
Project Status Completed (Fiscal Year 2005)
Budget Amount *help
¥3,600,000 (Direct Cost: ¥3,600,000)
Fiscal Year 2005: ¥400,000 (Direct Cost: ¥400,000)
Fiscal Year 2004: ¥500,000 (Direct Cost: ¥500,000)
Fiscal Year 2003: ¥2,700,000 (Direct Cost: ¥2,700,000)
KeywordsTRPV1 / CGRP / parasympathetic preganglionic cell / infrared sense / superior salivary nucleus / celiac ganglion / spinal ganglia / 交感節前細胞 / 後根神経節 / 排尿反射 / カルシトニン遺伝子関連ペプチド(CGRP) / 爬虫類
Research Abstract

(1) Ontogenic study of the neural pathways related to mouse visceral reflexes: In order to clarify the generating process of neural pathways related to the visceral reflexes of mammals, expression of TRPV1 in sensory nerves was investigated in prenatal mice. TRPV1 was observed in the dorsal root ganglion cells at E13, and also in the central terminals in the spinal cord. The period of TRPV1 expression in the peripheral processes was different among viscera, i.e., in the urinary tract and the rectum at E14-15, and in the trachea and in the bronchi at E18-P1. Moreover, the rate of coexistence of TRPV1 and calcitonin gene-related peptide (CGRP) varied greatly among organs; thus, the bronchi and the urinary tract showed a high rate of coexistence, and in the stomach and the large intestine, the rate was low. Moreover, in the spinal cord of prenatal mice, TRPV1 positive fibers and CGRP positive fibers projected directly to the parasympathetic preganglionic cells at the sacral level by E16. … More Therefore, the possibility that the reflective circuit related to the visceral reflexes from the urinary tract and the lower alimentary canal is completed by E16 was shown.
2) Phylogenic study of the neural circuit related to the visceral reflex: In the tracer experiments on the facial nerve of a pit viper, the existence and location of the superior salivary nucleus, which is general visceral efferent in nature, were confirmed. This nucleus mediates salivary gland secretion of the upper and lower jaws, and also participates in blood-flow regulation in the pit membrane, an infrared receptor of pit vipers. Since the superior salivary nucleus was close to the nucleus caloris which is a relay nucleus of infrared sensation, it was surmised that infrared sensation may affect the cranial parasympathetic nervous system through the nucleus caloris. We also explored the possibility that the sensory nerves originating in the dorsal root ganglia terminate in the celiac ganglion of Xenopus. When lesion experiments and capsaicin medication experiments were conducted, most nerve fibers enclosing the ganglion cells disappeared. Moreover, when the tracer was injected into the celiac ganglion, many neurons in the dorsal root ganglia were retrogradely labeled, and they contained SP. From this, the possibility that the sensory nerves perform reflective regulation via axon collaterals to the sympathetic postganglionic cells also in amphibians was suggested Less

Report

(4 results)
  • 2005 Annual Research Report   Final Research Report Summary
  • 2004 Annual Research Report
  • 2003 Annual Research Report
  • Research Products

    (11 results)

All 2006 2004 2003 Other

All Journal Article (10 results) Publications (1 results)

  • [Journal Article] Differential development of TRPV1-expressing sensory nerves in peripheral organs2006

    • Author(s)
      Funakoshi K et al.
    • Journal Title

      Cell Tissue Research 323・1

      Pages: 27-41

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Prenatal development of transient receptor potential vanilloid 1-expressing primary sensory projections to sacral autonomic preganglionic neurons2006

    • Author(s)
      Funakoshi K et al.
    • Journal Title

      Neuroscience Letters 407・3

      Pages: 230-233

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Differential development of TRPV1-expressing sensory nerves in peripheral organs2006

    • Author(s)
      Funakoshi K et al.
    • Journal Title

      Cell and Tissue Research 323(1)

      Pages: 27-41

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Prenatal development of transient receptor potential vanilloid 1-expressing primary sensory projections to sacral autonomic preganglionic neurons2006

    • Author(s)
      Funakoshi K et al.
    • Journal Title

      Neuroscience Letters 407(3)

      Pages: 230-233

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Differential development of TRPV1-expressing sensory nerves in peripheral organs2006

    • Author(s)
      Funakoshi K et al.
    • Journal Title

      Cell Tissue Research 323

      Pages: 27-41

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Medullary efferent and afferent neurons of the facial nerve of the pit viper Gloydius brevicaudus2004

    • Author(s)
      Atobe Y et al.
    • Journal Title

      Journal of Comparative Neurology 472・3

      Pages: 345-357

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Medullary efferent and afferent neurons of the facial nerve of the pit viper Gloydius brevicaudus2004

    • Author(s)
      Atobe Y et al.
    • Journal Title

      Journal of Comparative Neurology 472(3)

      Pages: 345-357

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Medullary efferent and afferent neurons of the facial nerve of the pit viper Gloydius brevicaudus2004

    • Author(s)
      Yoshitoshi Atobe et al.
    • Journal Title

      Journal of Comparative Neurology 472

      Pages: 345-357

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Prenatal development of peptidergic primary afferent projections to mouse lumbosacral autonomic preganglionic cell columns2003

    • Author(s)
      Funakoshi K et al.
    • Journal Title

      Developmental Brain Research 114・1

      Pages: 107-119

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Prenatal development of peptidergic primary afferent projections to mouse lumbosacral autonomic preganglionic cell columns2003

    • Author(s)
      Funakoshi K et al.
    • Journal Title

      Developmental Brain Research 144(1)

      Pages: 107-119

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Publications] Kengo Funakoshi et al.: "Prenatal development of peptidergic primary afferent projections to mouse lumbosacral autonomic preganglionic cell columns"Developmental Brain Research. 144. 107-119 (2003)

    • Related Report
      2003 Annual Research Report

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Published: 2003-04-01   Modified: 2016-04-21  

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