| Project/Area Number |
15500283
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Neurophysiology and muscle physiology
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| Research Institution | TOYAMA MEDICAL AND PHARMACEUTICAL UNIVERSITY |
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Principal Investigator |
TABUCHI Eiichi Toyama Medical and Pharmaceutical University, System Emotional Science, Associate Professor, 大学院・医学系研究科, 助教授 (70272911)
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| Co-Investigator(Kenkyū-buntansha) |
UMENO Katsumi Toyama Medical and Pharmaceutical University, System Emotional Science, Assistant Professor, 大学院・医学系研究科, 助手 (90086596)
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| Project Period (FY) |
2003 – 2004
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| Project Status |
Completed (Fiscal Year 2004)
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| Budget Amount *help |
¥3,600,000 (Direct Cost: ¥3,600,000)
Fiscal Year 2004: ¥1,300,000 (Direct Cost: ¥1,300,000)
Fiscal Year 2003: ¥2,300,000 (Direct Cost: ¥2,300,000)
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| Keywords | Limbic system / Posterior cingulate cortex / Neural network / Hippocampus / Neuron / Cross-correlation / Behavior / Reward |
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| Research Abstract |
We found that neurons in the posterior cingulate cortex respond not to sensory stimuli but to motor action for a certain reward acquisition. Also, it is found that the hippocampal regions having reciprocal connection with the posterior cingulate cortex alter their responses in accord with place and condition. In the present study, to clarify how the context dependent hippocampal information converted into the posterior cingulate cortex which acts on motor evaluation, we recorded multiple single neuronal activities simultaneously from the posterior cingulate cortex and hippocampus in a sensory-reward association learning task. In this task, a water deprived rat received water or an intracranial self-stimulation (ICSS) (both reward), when the rat pressed a lever at a lit wall in an octagonal arena. The arena was equipped with 4 levers where one of 4 different rewards (small or large volume of water, weak or strong ICSS) was delivered. Then, we analyzed the neuronal activities in behavioral correlates, and the neuronal connectivity between the 2 brain regions using the cross-correlation method.
We found significant cross-correlation peaks in some pairs between the posterior cingulate cortex and hippocampal neurons during drinking in a specific position. The time difference of their discharges was 10 ms. These findings suggest that the connection from the hippocampus to the posterior cingulate cortex may convey integrated information among space, reward, and motion.
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