Mechanism of information processing in the posterior cingulate cortex-hippocampal system

• Project/Area Number: 15500283
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Neurophysiology and muscle physiology
• Research Institution: TOYAMA MEDICAL AND PHARMACEUTICAL UNIVERSITY
• Principal Investigator: TABUCHI Eiichi Toyama Medical and Pharmaceutical University, System Emotional Science, Associate Professor, 大学院・医学系研究科, 助教授 (70272911)
• Co-Investigator(Kenkyū-buntansha): UMENO Katsumi Toyama Medical and Pharmaceutical University, System Emotional Science, Assistant Professor, 大学院・医学系研究科, 助手 (90086596)
• Project Period (FY): 2003 – 2004
• Project Status: Completed (Fiscal Year 2004)
• Budget Amount: ¥3,600,000 (Direct Cost: ¥3,600,000); Fiscal Year 2004: ¥1,300,000 (Direct Cost: ¥1,300,000); Fiscal Year 2003: ¥2,300,000 (Direct Cost: ¥2,300,000)
• Keywords: Limbic system / Posterior cingulate cortex / Neural network / Hippocampus / Neuron / Cross-correlation / Behavior / Reward

Research Abstract

We found that neurons in the posterior cingulate cortex respond not to sensory stimuli but to motor action for a certain reward acquisition. Also, it is found that the hippocampal regions having reciprocal connection with the posterior cingulate cortex alter their responses in accord with place and condition. In the present study, to clarify how the context dependent hippocampal information converted into the posterior cingulate cortex which acts on motor evaluation, we recorded multiple single neuronal activities simultaneously from the posterior cingulate cortex and hippocampus in a sensory-reward association learning task. In this task, a water deprived rat received water or an intracranial self-stimulation (ICSS) (both reward), when the rat pressed a lever at a lit wall in an octagonal arena. The arena was equipped with 4 levers where one of 4 different rewards (small or large volume of water, weak or strong ICSS) was delivered. Then, we analyzed the neuronal activities in behavioral correlates, and the neuronal connectivity between the 2 brain regions using the cross-correlation method.
We found significant cross-correlation peaks in some pairs between the posterior cingulate cortex and hippocampal neurons during drinking in a specific position. The time difference of their discharges was 10 ms. These findings suggest that the connection from the hippocampus to the posterior cingulate cortex may convey integrated information among space, reward, and motion.

Research Products

• [Journal Article] Differentiation of reward types in posterior cingulate cortex. (2005)
  • Author(s): Tabuchi E., Furusawa A.A., Hori E., Umeno K., Ono T., Nishijo H.
  • Journal Title: Neuroreport (in press)
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Neural correlates to action and rewards in the rat posterior cingulate cortex. (2005)
  • Author(s): Tabuchi, E., Furusawa, A.A., Hori, E., Umeno, K., Ono, T., Nishijo, H.
  • Journal Title: Neuroreport (in press)
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Neurons in hippocampal afferent zones of rat striatum parse routes into multi-pace segments during maze navigation. (2004)
  • Author(s): Mulder A.B., Tabuchi E., Wiener S.I.
  • Journal Title: European Journal of Neuroscience 19 Pages: 1923-1932
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] 食物報酬の認知と摂食行動の神経機構 (2004)
  • Author(s): 西条寿夫, 田渕英一, 小野武年
  • Journal Title: 肥満研究 10 Pages: 4-11
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Neurons in hippocampal afferent zones of rat striatum parse routes into multi-pace segments during maze navigation. (2004)
  • Author(s): Murder A.B., Tabuchi E., Wiener S.I.
  • Journal Title: European Journal of Neuroscience 19 Pages: 1923-1932
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Neurons in hippocampal afferent zones of rat striatum parse routes into multi-pace segments during maze navigation. (2004)
  • Author(s): Mulder, A.B., Tabuchi, E., Wiener S.I.
  • Journal Title: Eur.J.Neurosci. 19 Pages: 1923-1932
• [Journal Article] Reward value invariant place responses and reward site associated activity in hippocampal neurons of behaving rats. (2003)
  • Author(s): Tabuchi E., Mulder A.B., Wiener S.I.
  • Journal Title: Hippocampus 13 Pages: 117-132
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Representation of place by monkey hippocampal neurons in real and virtual translocation. (2003)
  • Author(s): Hori E., Tabuchi E., Matsumura N., Tamura R., Eifuku S., Endo S., Nishijo H., Ono T.
  • Journal Title: Hippocampus 13 Pages: 148-154
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Differential activation in the medial temporal lobe during a sound-sequence discrimination task across age in human subjects. (2003)
  • Author(s): Takakura H., Umeno K., Tabuchi E., Hori E., Miyamoto K., Aso S., Watanabe Y., Ono T., Nishijo H.
  • Journal Title: Neuroscience 119 Pages: 517-532
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Gamma-band EEGs predict autonomic responses during mental arithmetic. (2003)
  • Author(s): Umeno K., Hori E., Tabuchi E., Takakura H., Miyamoto K., Ono T., Nishijo H.
  • Journal Title: Neuroreport 14 Pages: 477-480
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Autonomic responses during inhalation of natural fragrance "Cedrol" in humans. (2003)
  • Author(s): Dayawansa S., Umeno K., Takakura M., Hori E., Tabuchi E., Nagashima Y., Oosu H., Yada Y., Suzuki T., Ono T., Nishijo H.
  • Journal Title: Autonomic Neuroscience-Basic & Clinical 108 Pages: 79-86
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Spatial and behavioral correlates in nucleus accumbens neurons in zones receiving hippocampal or prefrontal cortical inputs. (2003)
  • Author(s): Wiener S.I., Shibata R., Tabuchi E., Trullier O., Albertin S.V., Murder A.B
  • Journal Title: Cognition and Emotion in the Brain (by Ono T., Matsumoto G., Llinas R.R., Berthoz A., Norgren R., Nishijo H., Tamura R.(Eds.))(Elsevier, Amsterdam) Pages: 275-292
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Role of the monkey amygdala in social cognition. (2003)
  • Author(s): Nishijo H., Hori E., Tazumi T., Eifuku S., Umeno K., Tabuchi E., Ono T.
  • Journal Title: Cognition and Emotion in the Brain (by Ono T., Matsumoto G., Llinas R.R., Berthoz A., Norgren R., Nishijo H., Tamura R.(Eds.))(Elsevier, Amsterdam) Pages: 295-310
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Reward value invariant place responses and reward site associated activity in hippocampal neurons of behaving rats. (2003)
  • Author(s): Tabuchi, E., Murder, A.B., Wiener, S.I.
  • Journal Title: Hippocampus 13 Pages: 117-132
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Representation of place by monkey hippocampal neurons in real and virtual translocation. (2003)
  • Author(s): Hori, E., Tabuchi, E., Matsumura, N., Tamura, R., Eifuku, S., Endo, S., Nishijo, H., Ono, T.
  • Journal Title: Hippocampus 13 Pages: 148-154
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Differential activation in the medial temporal lobe during a sound-sequence discrimination task across age in human subjects. (2003)
  • Author(s): Takakura, H., Umeno, K., Tabuchi, E., Hori, E., Miyamoto, K., Aso, S., Watanabe, Y., Ono, T., Nishijo, H.
  • Journal Title: Neuroscience 119 Pages: 517-532
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Gamma-band EEGs predict autonomic responses during mental arithmetic. (2003)
  • Author(s): Umeno, K., Hori, E., Tabuchi, E., Takakura, H., Miyamoto, K., Ono, T., Nishijo, H.
  • Journal Title: Neuroreport 14 Pages: 477-480
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Differentiation of reward types in posterior cingulate cortex.
  • Author(s): Tabuchi, E., Furusawa, A.A., Hori, E., Umeno, K., Ono, T., Nishijo, H.
  • Journal Title: Neuroreport (in press)
• [Book] 書くだけで、気持ちが安らぐ写経の練習帖 (2005)
  • Author(s): 田渕英一, 岩松浅夫 監修, 阪野然犀 書
  • Total Pages: 171
  • Publisher: ダイヤモンド社
  • Description: 「研究成果報告書概要(和文)」より
• [Book] ボケないための脳トレーニングドリル (2004)
  • Author(s): 田渕英一
  • Total Pages: 95
  • Publisher: PHP研究所
  • Description: 「研究成果報告書概要(和文)」より
• [Book] Role of the monkey amygdala in social cognition. In : Cognition and Emotion in the Brain.(Ono T., Matsumoto G., Llinas R.R., Berthoz A., Norgren R., Nishijo H., Tamura R. (Eds.)) (2003)
  • Author(s): Nishijo H., Hori E., Tazumi T., Eifuku S., Umeno K., Tabuchi E., Ono T.
  • Publisher: Amsterdam, Elsevier
  • Description: 「研究成果報告書概要(和文)」より
• [Book] Spatial and behavioral correlates in nucleus accumbens neurons in zones receiving hippocampal or prefrontal cortical inputs. In : Cognition and Emotion in the Brain.(Ono T., Matsumoto G., Llinas R.R., Berthoz A., Norgren R., Nishijo H., Tamura R. (Eds.)) (2003)
  • Author(s): Wiener S.I., Shibata R., Tabuchi E., Trullier O., Albertin S.V., Mulder A.B.
  • Publisher: Amsterdam, Elsevier
  • Description: 「研究成果報告書概要(和文)」より
• [Publications] Dayawansa S, Umeno K, Takakura M, Hori E, Tabuchi E, Nagashima Y, Oosu H, Yada Y, Suzuki T, Ono T, Nishijo H: "Autonomic responses during inhalation of natural fragrance "Cedrol" in humans."Autonomic Neuroscience-Basic & Clinical. 108. 79-86 (2003)
• [Publications] Umeno K, Hori E, Tabuchi B, Takakura H, Miyamoto K, Ono T, Nishijo H: "Gamma-band BEGs predict autonomic responses during mental arithmetic"Neuroreport. 14. 477-480 (2003)
• [Publications] Takakura H, Umeno K, Tabuchi E, Hori E, Miyamoto K, Aso S, Watanabe Y, Ono T, Nishijo H: "Differential activation in the medial temporal lobe during a sound-sequence discrimination task across age in human subjects"Neuroscience. 119. 517-532 (2003)
• [Publications] Tabuchi B, Mulder AB, Wiener SI: "Reward value invariant place responses and reward site associated activity in hippocampal neurons of behaving rats"Hippocampus. 13. 117-132 (2003)
• [Publications] Hori E, Tabuchi E, Matsumura N, Tamura R, Eifuku S, Endo S, Nishijo H, Ono T: "Representation of place by monkey hippocampal neurons in real and virtual translocation"Hippocampus. 13. 148-154 (2003)
• [Publications] Nishijo H., Hori E, Tazumi T, Eifuku S, Umeno K, Tabuchi B, Ono T.: "Role of the monkey amygdala in social cognition. In : Cognition and Emotion in the Brain"T Ono, G Matsumoto, RR Llinas, A Berthoz, R Norgren, H Nishijo, R Tamura, eds.Elsevier. 295-310 (2003)