| Project/Area Number |
15500290
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Single-year Grants |
|---|
| Section | 一般 |
|---|
| Research Field |
Neurophysiology and muscle physiology
|
|---|
| Research Institution | Kinki University |
|---|
Principal Investigator |
INASE Masahiko Kinki University, School of Medicine, Professor, 医学部, 教授 (80249961)
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
OSHIO Ken-ichi Kinki University, School of Medicine, Assistant, 医学部, 助手 (30296751)
|
|---|
| Project Period (FY) |
2003 – 2004
|
| Project Status |
Completed (Fiscal Year 2004)
|
| Budget Amount *help |
¥3,300,000 (Direct Cost: ¥3,300,000)
Fiscal Year 2004: ¥1,400,000 (Direct Cost: ¥1,400,000)
Fiscal Year 2003: ¥1,900,000 (Direct Cost: ¥1,900,000)
|
|---|
| Keywords | conditional motor kearning / cerebral cortex / prefrontal cortex / primate / neuronal activity / basal ganglia / stimulus response / association learning / 運動学習 / 神経生理学 |
|---|
| Research Abstract |
In order to examine functional roles of the prefrontal cortex in arbitrary visuomotor association, we recorded neuronal activity in the medial prefrontal cortex, area 9m, of a behaving monkey during conditional visuomotor learning. The monkey was presented a cueing visual stimulus, and following a delay period required to push, pull, or turn a manipulator according to the cue. Under the control condition three cues instructed the monkey to the three responses in a block of trials. After a few months of training the animal was familiar with these associations. Under the learning condition, two of the three familiar cues and one novel cue were presented in a block. The monkey needed to learn a new cue-response association by trial and error. Area 9m neurons responded to cue presentation. The Cue responses changed whether a cue was familiar or novel. A group of area 9m neurons responded to a novel cue, bur not to familiar ones. Other group of neurons responded to familiar cues, but not to a novel one. In a subgroup of these familiar cue-selective neurons the cue responses were enhanced under the learning condition compared to the control condition. These results suggest that cue familiarity is represented in area 9m activity and/or that the activity may be involved in action selection during the arbitrary visuomotor association learning.
|
