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Development of evaluation and diagnostic method on integration and its disorders of mental and language functions by analysis of synchronous oscillations in brain

Research Project

Project/Area Number 15500312
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Biomedical engineering/Biological material science
Research InstitutionThe University of Tokyo

Principal Investigator

ITOH Kenji  The University of Tokyo, Graduate School of Medicine, Research Associate, 大学院・医学系研究科, 助手 (80010106)

Co-Investigator(Kenkyū-buntansha) YUMOTO Masato  The University of Tokyo, Faculty of Medicine Hospital, Research Associate, 医学部附属病院, 助手 (30240170)
KASAI Kiyoto  The University of Tokyo, Faculty of Medicine Hospital, Lecturer, 医学部附属病院, 講師 (80322056)
UNO Akira  Tsukuba University, School of Comprehensive Human Sci, Associate Professor, 大学院・人間総合科学研究科, 助教授 (10270688)
NAKAGOME Kazuyuki  Showa University, Faculty of Medicine Hospital, Associate Professor, 医学部附属病院, 助教授 (30198056)
IWANAMI Akira  Aino University, Faculty of Medical Health, Professor, 医療保健学部, 教授 (80276518)
越田 一郎  東京工科大学, 工学部, 教授 (00192055)
Project Period (FY) 2003 – 2004
Project Status Completed (Fiscal Year 2004)
Budget Amount *help
¥3,700,000 (Direct Cost: ¥3,700,000)
Fiscal Year 2004: ¥1,300,000 (Direct Cost: ¥1,300,000)
Fiscal Year 2003: ¥2,400,000 (Direct Cost: ¥2,400,000)
Keywordspersonality / high-density EEG and MEG / high-frequency oscillation / spectral analysis / social skill training / cognitive and language disorder / empathy / diagnostic speech / 高密度脳波 / コヒーレンス / 認知障害 / ジェスチャー / 対話
Research Abstract

We aimed to develop an evaluation and diagnostic method with behavioral as well as brain imaging and functional data on integration and its disorders of mental, language and music functions in normal, musicians and schizophrenics on the basis of the binding problem in distributed inter-/intra-hemispheric synchronous system related to personal ability and creativity in higher cognitive and verbal communications.
1.We investigated the algorism of extracting effective brain event-related potentials and oscillations, as well as their correlation analysis for specifying personal ability, mental as well as language disorders based on the cortico-subcortical system.
2.We extended the method of correlation analysis by including brain morphological data and personal rating on verbal and cognitive abilities.
3.We made verbal as well as music sound and graphic files for audio-visual tasks of new mismatch negativity paradigm.
4.We improved the integrated database system on mental and language disorders.
5.We tried to apply the system to evaluate mental and language disorders, training effectiveness as well as to establish individual training program
By introducing the knowledge on quantitative test for cognitive and verbal disorders, we confirmed the clinical applicability of the system.

Report

(3 results)
  • 2004 Annual Research Report   Final Research Report Summary
  • 2003 Annual Research Report
  • Research Products

    (51 results)

All 2005 2004 2003 Other

All Journal Article (42 results) Book (2 results) Publications (7 results)

  • [Journal Article] Auditory imagery mismatch negativity elicited in musicians2005

    • Author(s)
      Yumoto M, Matsuda M, Itoh K, Uno A, Karino S, Kaga K
    • Journal Title

      NeuroReport 16(in press)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Audiovisual phonological mismatch produces early negativity in auditory cortex2005

    • Author(s)
      Yumoto M, Uno A, Itoh K, Karino S, Saitoh O, Kaga K
    • Journal Title

      NeuroReport 16(in press)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Brain electric activity for active inhibition of auditory irrelevant information2005

    • Author(s)
      Araki T, Kasai K, Nakagome K, Fukuda M, Itoh K, Iwanami A
    • Journal Title

      Neuroscience Letters 374

      Pages: 11-16

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] A modified parallel paradigm for clinical evaluation of auditory echoic memory2005

    • Author(s)
      Karino S, Yumoto M, Itoh K, Yamakawa K, Mizuochi T, Kaga K
    • Journal Title

      NeuroReport 16

      Pages: 683-688

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Perceptual categorization of sound spectral envelopes reflected in auditory-evoked N1m2005

    • Author(s)
      Mizuochi T, Yumoto M, Karino S, Itoh K, Yamakawa K, Kaga K
    • Journal Title

      NeuroReport 16

      Pages: 555-558

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Effect of the spectral envelope on the auditory evoked N100m2005

    • Author(s)
      Mizuochi T, Yumoto M, Karino S, Itoh K, Yamakawa K, Kaga K
    • Journal Title

      International Congress Series 1278

      Pages: 247-250

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] 対話における共感の基本過程の神経モデル化2005

    • Author(s)
      伊藤憲治, 丹羽真一, 加我君孝
    • Journal Title

      2005年電子情報通信学会総合大会講演論文集 1

      Pages: 232-232

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Spatiotemporal neuromagnetic activities during pitch processing in musicians.2005

    • Author(s)
      Yumoto M, Uno A, Itoh K, Matuda M, Karino S, Kaga K
    • Journal Title

      NeuroReport 16 (in press)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Audiovisual phonological mismatch produces early negativity in auditory cortex.2005

    • Author(s)
      Yumoto M, Uno A, Itoh K, Karino S, Saitoh O, Kaga K
    • Journal Title

      NeuroReport 16 (in press)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Brain electric activity for active inhibition of auditory irrelevant information.2005

    • Author(s)
      Araki T, Kasai K, Nakagome K, Fukuda M, Itoh K, Iwanami A
    • Journal Title

      Neuroscience Letters 374

      Pages: 11-16

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] A modified parallel paradigm for clinical evaluation of auditory echoic memory.2005

    • Author(s)
      Karino S, Yumoto M, Itoh K, Yamakawa K, Mizuochi T, Kaga K
    • Journal Title

      NeuroReport 16

      Pages: 683-688

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Perceptual categorization of sound spectral envelopes reflected in auditory-evoked N1m.2005

    • Author(s)
      Mizuochi T, Yumoto M, Karino S, Itoh K, Yamakawa K, Kaga K
    • Journal Title

      NeuroReport 16

      Pages: 555-558

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Effect of the spectral envelope on the auditory evoked N100m.2005

    • Author(s)
      Mizuochi T, Yumoto M, Karino S, Itoh K, Yamakawa K, Kaga K
    • Journal Title

      International Congress Series 1278

      Pages: 247-250

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] A Basic neural model of empathy in communication.2005

    • Author(s)
      Itoh K, Niwa S, Kaga K
    • Journal Title

      Proceedings of the 2005 IEICE General Conference 1

      Pages: 232-232

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Brain electric activity for active inhibition of auditory irrelevant information2005

    • Author(s)
      Araki T, Kasai K, Nakagome K, Fukuda M, Itoh K, Iwanami A
    • Journal Title

      Neuroscience Letters 374・1

      Pages: 11-16

    • Related Report
      2004 Annual Research Report
  • [Journal Article] A modified parallel paradigm for clinical evaluation of auditory echoic memory2005

    • Author(s)
      Karino S, Yumoto M, Itoh K, Yamakawa K, Mizuochi T, Kaga K
    • Journal Title

      Neuro Report 16(in press)

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Perceptual categorization of sound spectral envelopes reflected in auditory-evoked N1m2005

    • Author(s)
      Mizuochi T, Yumoto M, Karino S, Itoh K, Yamakawa K, Kaga K
    • Journal Title

      Neuro Report 16(in press)

    • Related Report
      2004 Annual Research Report
  • [Journal Article] 対話における共感の基本過程の神経モデル化2005

    • Author(s)
      伊藤憲治, 丹羽真一, 加我君孝
    • Journal Title

      2005年電子情報通信学会総合大会講演論文集 1(印刷中)

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Spatiotemporal neuromagnetic activities during pitch processing in musicians2004

    • Author(s)
      Yumoto M, Uno A, Itoh K, Matsuda M, Karino S, Kaga K
    • Journal Title

      International Congress Series 1270

      Pages: 173-176

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Magnetoencephalographic study of human auditory steady-state responses to binaural beat2004

    • Author(s)
      Karino S, Yumoto M, Itoh K, Uno A, Sekimoto S, Yamakawa K, Kaga K
    • Journal Title

      International Congress Series 1270

      Pages: 169-172

    • NAID

      40020281399

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] A modified parallel paradigm for clinical evaluation of auditory echoic memory using magnetoencephalography2004

    • Author(s)
      Karino S, Yumoto M, Itoh K, Yamakawa K, Mizuochi T, Kaga K
    • Journal Title

      Abstracts of the 8^<th> International Evoked Potentials Symposium 1

      Pages: 346-346

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Effects of the spectral envelope on the auditory evoked N100m2004

    • Author(s)
      Mizuochi T, Yumoto M, Karino S, Itoh K, Yamakawa K, Kaga K
    • Journal Title

      Abstracts of the 8^<th> International Evoked Potentials Symposium 1

      Pages: 345-345

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Effect of long-term musical environment on brain activity : violin vs. piano2004

    • Author(s)
      Uno A, Itoh K, Yumoto M, Kaga K
    • Journal Title

      Proceedings of ICA 2004, 18th International Congress on Acoustics 2

      Pages: 1761-1764

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] 音楽と言語の視聴覚統合:視聴覚間逸脱刺激による音楽家の脳磁場2004

    • Author(s)
      湯本真人, 伊藤憲治, 宇野彰, 狩野章太郎, 松田眞樹, 加我君孝
    • Journal Title

      臨床神経生理学 32

      Pages: 469-469

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] 縦書き,横書きの視覚刺激に関するRP(Recognition Potential)脳磁場反応2004

    • Author(s)
      山川恵子, 伊藤憲治, 湯本真人, 宇野彰, 加我君孝
    • Journal Title

      電子情報通信学会技術研究報告 103(656)

      Pages: 19-24

    • NAID

      110003314216

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] 言語認知活動解析を目的とした3次元脳機能情報提示システム2004

    • Author(s)
      越田一郎, 伊藤憲治, 植月美希, 岩波明, 丹羽真一
    • Journal Title

      電子情報通信学会2004ソサイティ大会講演論文集 1

      Pages: 165-165

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] 言語認知脳活動における事象関連発振・電位の相関解析2004

    • Author(s)
      伊藤憲治, 越田一郎, 植月美希, 岩波明, 丹羽真一, 加我君孝
    • Journal Title

      電子情報通信学会2004ソサイティ大会講演論文集 1

      Pages: 164-164

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Spatiotemporal neuromagnetic activities during pitch processing in musicians.2004

    • Author(s)
      Yumoto M, Uno A, Itoh K, Matuda M, Karino S, Kaga K
    • Journal Title

      International Congress Series 1270

      Pages: 173-176

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] A modified parallel paradigm for clinical evaluation of auditory echoic memory.2004

    • Author(s)
      Karino S, Yumoto M, Itoh K, Yamakawa K, Mizuochi T, Kaga K
    • Journal Title

      International Congress Series 1270

      Pages: 169-172

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] A modified parallel paradigm for clinical evaluation of auditory echoic memory using magnetoencephalography.2004

    • Author(s)
      Karino S, Yumoto M, Itoh K, Yamakawa K, Mizuochi T, Kaga K
    • Journal Title

      Abstracts of the 8^<th> International Evoked Potentials Symposium 1

      Pages: 346-346

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Effect of the spectral envelope on the auditory evoked N100m.2004

    • Author(s)
      Mizuochi T, Yumoto M, Karino S, Itoh K, Yamakawa K, Kaga K
    • Journal Title

      Abstracts of the 8^<th> International Evoked Potentials Symposium 1

      Pages: 345-345

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Effect of long-term musical environment on brain activity ; violin vs. piano.2004

    • Author(s)
      Uno A, Itoh K, Yumoto M, Kaga K
    • Journal Title

      Proceedings of ICA 2004, 18th International Congress on Acoustics 2

      Pages: 1761-1764

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Audiovisual integration of music and language : neuromagnetic activities by mismatch audiovisual stimuli in musicians.2004

    • Author(s)
      Yumoto M, Itoh K, Uno A, Karino S, Matuda M, Kaga K
    • Journal Title

      Japanese Journal of Clinical Neurophysiology 32

      Pages: 469-469

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Magnetoencephalographic study on the recognition potential -Responses to vertically and horizontally arranged words and visual stimuli-.2004

    • Author(s)
      Yamakawa K, Itoh K, Yumoto M, Uno A Kaga K
    • Journal Title

      Technical Report of IEICE 103(656)

      Pages: 19-24

    • NAID

      110003314216

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] A 3D visialization system for liguistic cognitive brain activity analysis.2004

    • Author(s)
      Koshida I, Itoh K, Uetsuki M, Iwanami A, Niwa S
    • Journal Title

      Proceedings of the 2004 IEICE Sciety Conference 1

      Pages: 165-165

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] A correlational analysis of eventrelated oscillations and potentials in linguistic and cognitive brain activities.2004

    • Author(s)
      Itoh K, Koshida I, Uetsuki M, Iwanami A, Niwa S, Kaga K
    • Journal Title

      Proceedings of the 2004 IEICE Sciety Conference 1

      Pages: 164-164

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] A modified parallel paradigm for clinical evaluation of auditory echoic memory using2004

    • Author(s)
      Karino S, Yumoto M, Itoh K, Yamakawa K, Mizuochi T, Kaga K
    • Journal Title

      Abstracts of the 8th International Evoked Potentials Symposium 8・1

      Pages: 346-346

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Effect of long-term musical environment on brain activity ; violin vs.piano2004

    • Author(s)
      Uno A, Itoh K, Yumoto M, Kaga K
    • Journal Title

      Proceedings of ICA 2004,18th International Congress on Acoustics 2

      Pages: 1761-1764

    • Related Report
      2004 Annual Research Report
  • [Journal Article] 大脳機能における長期的な音楽教育環境の違いによる影響-音高と音色および左右大脳半球間差-2003

    • Author(s)
      宇野彰, 加我君孝, 伊藤憲治, 湯本真人
    • Journal Title

      電子情報通信学会技術研究報告 103(307)

      Pages: 15-18

    • NAID

      110003314202

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Binaural Beatに誘発される脳磁場活動2003

    • Author(s)
      狩野章太郎, 湯本真人, 伊藤憲治, 宇野 彰, 関本荘太郎, 加我君孝
    • Journal Title

      電子情報通信学会技術研究報告 103(307)

      Pages: 11-14

    • NAID

      40020281399

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Effect of long-term musical environment on brain activity environmental -pitch, timbre and functional difference between right and left hemisphere-.2003

    • Author(s)
      Uno A, Kaga K, Itoh K, Yumoto M
    • Journal Title

      Technical Report of IEICE 103(307)

      Pages: 15-18

    • NAID

      110003314202

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Magnetoencephalographic study of human auditory steady-state responses to binaural beat.2003

    • Author(s)
      Karino S, Yumoto M, Itoh K, Sekimoto S, Kaga K
    • Journal Title

      Technical Report of IEICE 103(307)

      Pages: 11-14

    • NAID

      40020281399

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Book] スペクトル解析ハンドブック2004

    • Author(s)
      日野幹雄(監), 吉川昭, 佐藤俊輔, 伊藤憲治, 他(共著)
    • Total Pages
      621
    • Publisher
      朝倉書店:東京
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Book] Handbook of Spectral Analysis2004

    • Author(s)
      Hino M (ed), Kikkawa S, Sato S, Itoh K, et al.
    • Total Pages
      621
    • Publisher
      Asakura : Tokyo
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Publications] Kasai K, Yamada H, Kamio S, Nakagome K, Itoh K, et al.: "Neuromagnetic correlates of impaired automatic categorical perception of speech sounds in schizophrenia"Schizophrenia Research. 59・2-3. 159-172 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] 狩野章太郎, 湯本真人, 伊藤憲治, 宇野彰, 加我君孝, 他: "Binaural Beatに誘発される脳磁場活動"電子情報通信学会技術研究報告. 103・307. 11-14 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] 宇野彰, 伊藤憲治, 湯本真人, 加我君孝: "脳機能における長期的な音楽教育環境の違いによる影響;音高と音色および左右大脳半球間差"電子情報通信学会技術研究報告. 103・307. 15-18 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] 山川恵子, 伊藤憲治, 湯本真人, 宇野彰, 加我君孝: "縦書き,横書きの視覚刺激に関するRP(Recognition Potential)脳磁場反応"電子情報通信学会技術研究報告. 103・656. 19-24 (2004)

    • Related Report
      2003 Annual Research Report
  • [Publications] 湯本真人, 松田眞樹, 伊藤憲治, 宇野彰, 加我君孝, 他: "読譜に伴う脳磁場活動"第33回日本臨床神経生理学会学術大会予稿集. 33・1. 195-195 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] 越田一郎, 伊藤憲治, 植月美希, 笠井清登, 福田真人, 丹羽真一, 他: "事象関連発振の多帯域相関解析による言語認知活動の検討"第33回日本臨床神経生理学会学術大会予稿集. 33・1. 300-300 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] 日野幹雄, 吉川昭, 佐藤俊輔, 伊藤憲治, 他(共著): "スペクトル解析ハンドブック"朝倉書店. 621 (2004)

    • Related Report
      2003 Annual Research Report

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Published: 2003-04-01   Modified: 2016-04-21  

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