| Project/Area Number |
15500321
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Biomedical engineering/Biological material science
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| Research Institution | Faculty of Pharmaceutical Sciences, Health Science University of Hokkaido |
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Principal Investigator |
MIYAZAKI Shozo Health Science University of Hokkaido, Faculty of Pharmaceutical Sciences, Professor, 薬学部, 教授 (70095321)
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| Co-Investigator(Kenkyū-buntansha) |
KUBO Wataru Health Science University of Hokkaido, Faculty of Pharmaceutical Sciences, Research Associate, 薬学部, 助手 (10347768)
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| Project Period (FY) |
2003 – 2004
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| Project Status |
Completed (Fiscal Year 2004)
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| Budget Amount *help |
¥3,100,000 (Direct Cost: ¥3,100,000)
Fiscal Year 2004: ¥900,000 (Direct Cost: ¥900,000)
Fiscal Year 2003: ¥2,200,000 (Direct Cost: ¥2,200,000)
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| Keywords | intelligent polymers / thereto-responsible gelation / nanoparticles / sustained release liquid formulatios / drugs / ionic-responsible gelation |
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| Research Abstract |
1.The purpose of this study was concerned with the development of sustained release liquid formulatios for the elderly and the infant using thermo-responsible gelation of Pluronic F-127 and xyloglucan or ionic-responsible gelation of Pectin. All of which were designed to be administered in liquid dosage forms and to form gels in situ in the acidic environment of stomach. We have demonstratated the potential as sustained release vehicles of gels formed in situ following the oral administration of aqueous solutions of these intelligent polymers by in vitro and in vivo studies. The viscosities of all of these formulations were sufficiently low that no difficulties with swallowing were envisaged. 2.An oral drug delivery could possibly be improved if nanoparticle carrier system was incorporated into an intelligent polymer liquid formulation. In this study, poly n-butylcyanoacrylate(PNBCA) nanocapsules of indomethacin were prepared by interfacial polymerization. The physicochemical characterization of the PNBCA nanocapsules was performed by measuring the drug content by HPLC and analyzing the particle size using SEM. The drug loading results indicated that 76.6% of indomethacin was loaded onto the F'NBCA nanocapsules, the average particle size was 188 nm. The presented data expected that indomethacin loaded PNBCA nanocapsules could improve the oral drug delivery compared to a conventional gel formulation. This might be due to their ultra fine particle size and their hydrophilic and hydrophobic surface characteristics.
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