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Importance of angiopolarity to obtain long-term stability in tissue engineering biomaterials

Research Project

Project/Area Number 15500328
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Biomedical engineering/Biological material science
Research InstitutionTokyo Women's Medical University

Principal Investigator

GOYA Nobuyuki  Tokyo Women's Medical University, Dept of Urology, Associate Professor, 医学部, 助教授 (40142492)

Co-Investigator(Kenkyū-buntansha) TOMIZAWA Yasuko  Tokyo Women's Medical University, Dept of Cardiovascular Surgery, Instructor, 医学部, 助手 (00159047)
Project Period (FY) 2003 – 2004
Project Status Completed (Fiscal Year 2004)
Budget Amount *help
¥3,200,000 (Direct Cost: ¥3,200,000)
Fiscal Year 2004: ¥1,200,000 (Direct Cost: ¥1,200,000)
Fiscal Year 2003: ¥2,000,000 (Direct Cost: ¥2,000,000)
Keywordstissue engineering / angiogenesis / wound healing / scaffold / REC / remodeling / sprout formation / vessel / 遠隔期 / 配向性 / angiopolarity / アテロコラーゲン / グラフト / 代謝 / 細胞
Research Abstract

The progress in the field of tissue engineering is rapid. We expect that the latest innovations will solve all the problems associated with the current disadvantages of implantable biomaterials, such as deterioration, scar formation and calcification. Recently, atrophic changes of implanted tissue with reduction of vessel density have been noticed, especially in non-functional cosmetic implants. Due to unequal biocompatibility of biomaterials, "angiopolarity", defined as the orientation or direction of angiogenesis into biomaterials after implantation, occurs in the process of wound healing and should influence metabolic stability in the long-term. To investigate cell affinity and angiopolarity, we evaluated commercially available local hemostats, injectable collagen and other biomaterials using a rabbit ear chamber wound healing model. We observed smooth angiogenesis with a cotton-type collagen scaffold made of atelocollagen, since the movement of body fluid from respiration and venous pulse wave were not restricted by the implanted material and they propagated equally at the edge and in the center of the rabbit ear chamber. When vessel sprouts extend to and reach the collagen fiber, they crossed the fiber by going over the ridge. However, cell affinity was not satisfactory in most of the commercially available collagen hemostatic agents tested. We believed that good-angiopolarity just after implantation is the key factor to obtain stability of tissue engineered biomaterial in the long-term.

Report

(3 results)
  • 2004 Annual Research Report   Final Research Report Summary
  • 2003 Annual Research Report
  • Research Products

    (7 results)

All 2004 Other

All Journal Article (5 results) Publications (2 results)

  • [Journal Article] Transurethral Ethanol Injection Therapy for Prostatic Hyperplasia : 3-Year Results2004

    • Author(s)
      Goya N, et al.
    • Journal Title

      J Urol 172

      Pages: 1017-1020

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] 局所止血材の細胞毒性と組織親和性のin vitroおよびin vivo評価2004

    • Author(s)
      冨澤康子, 他
    • Journal Title

      日本心臓血管外科学会雑誌 33

      Pages: 382-386

    • NAID

      10016520747

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Annual Research Report 2004 Final Research Report Summary
  • [Journal Article] Transurethral ethanol injection therapy for prostatic hyperplasia : 3-year results2004

    • Author(s)
      Goya N, Ishikawa N, Ito F, Kobayashi C, Tomizawa Y, Toma H.
    • Journal Title

      J Urol 172

      Pages: 1017-1020

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] In vitro and in vivo evaluation of the biocompatibility and cytotoxicity of local hemostatic agents2004

    • Author(s)
      Tomizawa Y, Komori M, Takada K, Nishida H, Endo M, Kurosawa H.
    • Journal Title

      Jpn J Cardiovasc Surg 33

      Pages: 382-386

    • NAID

      10016520747

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Transurethral Ethanol Injection Therapy for Prostatic Hyperplasia: 3-Year Results2004

    • Author(s)
      Goya N, et al.
    • Journal Title

      J Urol 172

      Pages: 1017-1020

    • Related Report
      2004 Annual Research Report
  • [Publications] 石川暢夫, 合谷信行, 他: "腎移植患者の尿路感染"腎と透析. 55. 80-83 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] 合谷信行, 他: "前立腺肥大症に対するエタノール注入療法 経尿道的および経会陰的方法"臨床泌尿器科. 57. 342-347 (2003)

    • Related Report
      2003 Annual Research Report

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Published: 2003-04-01   Modified: 2016-04-21  

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