| Project/Area Number |
15500355
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Medical systems
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| Research Institution | Fukuoka University |
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Principal Investigator |
YAMASHITA Yuichi Fukuoka University, Hospital, Professor, 病院, 教授 (50182506)
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| Co-Investigator(Kenkyū-buntansha) |
MAEKAWA Takafumi Fukuoka University, Hospital, Lecturer, 病院・講師 (80209361)
HOSHINO Seiichiro Fukuoka University, School of Medicine, Assistant Professor, 医学部, 助手 (90352260)
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| Project Period (FY) |
2003 – 2004
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| Project Status |
Completed (Fiscal Year 2004)
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| Budget Amount *help |
¥3,700,000 (Direct Cost: ¥3,700,000)
Fiscal Year 2004: ¥1,900,000 (Direct Cost: ¥1,900,000)
Fiscal Year 2003: ¥1,800,000 (Direct Cost: ¥1,800,000)
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| Keywords | ultrasound / cancer therapy / porphyrin / colon / rectum |
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| Research Abstract |
Photodynamic therapy(PDT) using hematoporphirin and laser has been clinically used as a modality for cancer treatment. Photosensitizing drug used in PDT is selectively retained by tumors compared with normal tissues. However, laser penetrates few mm in the surface of organ. On the other hand, ultrasound has an appropriate tissue attenuation, and activates active hematoporphyrins. Therefore, combination of those two caused an inhibition of tumor growth. The effect of combination of such chemical drugs and ultrasound has been called sonodynamic therapy(SDT). We performed SDT for patients with cancer. We report here those cases treated with SDT.
Patients and Methods:
Prior to SDT, we have gotten permission of clinical application of SDT from ethical committee, and informed consent from each patient. Patient have been treated with every possible therapy. However, tumor growth could not be inhibited. Prior to ultrasound exposure, Photofrin^R was administrated intravenously at a dose of 2mg/kg
… More
in a dark room. Ultrasound exposure was performed 48-72hrs after the administration. Ultrasound was used at a intensi ty of 2-4w/cm^2 for 1hr. The patient stayed in dark room after a intravenous administration of PhotofrinR for two weeks.
Results :
SDT could be performed uneventfully. None of the side effects was also observed after the treatment. SDT alleviated the pain by cancer during therapy. Internal echo pattern of a huge rectal cancer was gradually changed to irregular low echoic level. Anti-tumor effect by SDT could not be observed in this case because of increment of serum CA19-9 level.
Discussion :
Anticancer effect by SDT using Photofrin^R and 1MHz ultrasound in our clinical study was observed a change of echo level in a huge rectal tumor. however, its efficacy was seemed not to be obvious compared with that in vitro study reported previously. Residual viable cells after treatment of SDT could proliferated normally in our another study. The Effect of SDT did not be estimated with this patient because application of SDT was once for this patient. Repetition of drug treatment is clinically common for cancer therapy. Therefore, repeated SDT was mandatory to evaluate clinical effect of SDT, and accumulation of Patients treated with SDT is also necessary to evaluate this therapy. Less
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