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NEW METHOD OF EVALUATING MUSCLE FUNCTION WITH MAGNETIC RESONANCE IMAGER

Research Project

Project/Area Number 15500365
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Rehabilitation science/Welfare engineering
Research InstitutionKyushu University

Principal Investigator

HATAKENAKA Masamitsu  Kyushu University, University Hospital, Radiology, Assistant professor, 大学病院, 講師 (40253413)

Co-Investigator(Kenkyū-buntansha) HONDA Hiroshi  Kyushu University, Faculty of Medicine, Clinical Radiology, Professor, 大学院・医学研究院, 教授 (90145433)
YOSHIMITSU Kengo  Kyushu University, University Hospital, Radiology, Assistant professor, 大学病院, 講師 (20274467)
YABUUCHI Hidetake  Kyushu University, University Hospital, Radiology, Assistant, 大学病院, 助手 (70380623)
薮内 英剛  九州大学, 大学院・医学研究院, 助手
高橋 直幹  九州大学, 大学病院, 医員
足立 利貞  九州大学, 大学病院, 助手 (10335979)
前田 豊樹  九州大学, 生体防御医学研究所, 助手 (30264112)
Project Period (FY) 2003 – 2005
Project Status Completed (Fiscal Year 2005)
Budget Amount *help
¥3,500,000 (Direct Cost: ¥3,500,000)
Fiscal Year 2005: ¥900,000 (Direct Cost: ¥900,000)
Fiscal Year 2004: ¥1,000,000 (Direct Cost: ¥1,000,000)
Fiscal Year 2003: ¥1,600,000 (Direct Cost: ¥1,600,000)
Keywordssteroid / myopathy / MR / relaxation time / diffusion / MRI / ADC
Research Abstract

Purpose :
To determine whether muscle fiber atrophy associated with steroid myopathy can be detected with T2 relaxation time.
Materials and Methods:
Animal and human studies were approved by the ethics committee. Informed consent was obtained. Twelve rabbits were divided into a group that received 3 mg/kg of triamcinolone subcutaneously each day for 10 consecutive days (n_6) and a control group that received saline (n_6). Magnetic resonance (MR) imaging was performed before and after treatment. T2 and fat deposition ratio (FDR) of soleus and gastrocnemius muscles before and after treatment and between control rabbits and rabbits treated with steroids were compared by using two-way repeated analysis of variance and Bonferroni post hoc test to evaluate effects of steroid treatment. After imaging, rabbits were sacrificed. Extracellular space ratio (ECSR) and fiber diameter were examined. Correlation among T2, ECSR, and diameter of type 2 muscle fibers was analyzed with a Pearson correlation … More test with Bonferroni correction in gastrocnemius to determine factors affecting T2. In humans, T2 relaxation time and FDR of both muscles were compared between volunteers not treated with steroids and patients treated with steroids by using an unpaired t test to evaluate the effects of steroids.
Results :
In rabbits, T2 of gastrocnemius muscle was significantly (P_.01) longer after steroid treatment than before steroid treatment and was also significantly (P_.01) longer than after saline administration. T2 of the gastrocnemius showed no significant difference in control rabbits before or after saline administration or in control rabbits and rabbits before steroid administration. T2 of the soleus muscle or FDR of either muscle showed no significant difference. There was a significant correlation (P_.01) among T2, ECSR, and diameter of type 2 muscle fibers in the gastrocnemius. In humans, T2 of the gastrocnemius was significantly (P_.01) longer in patients than in volunteers. T2 of the soleus or FDR of eithermuscle showed no significant difference.
Conclusion :
Muscle fiber atrophy associated with steroid myopathy is detectable as prolongation of T2 relaxation time in the gastrocnemius muscle ; the authors believe prolongation of T2 relaxation time is mainly due to increased ECSR reflecting type 2 muscle fiber atrophy. Less

Report

(4 results)
  • 2005 Annual Research Report   Final Research Report Summary
  • 2004 Annual Research Report
  • 2003 Annual Research Report
  • Research Products

    (2 results)

All 2006

All Journal Article (2 results)

  • [Journal Article] Steroid Myopathy : Evaluation of Fiber Atrophy with T2 Relaxation Time-Rabbit and Human Study2006

    • Author(s)
      Hatakenaka M et al.
    • Journal Title

      Radiology 238

      Pages: 650-657

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Annual Research Report 2005 Final Research Report Summary
  • [Journal Article] Steroid Myopathy : Evaluation of Fiber Atrophy with T2 Relaxation Time-Rabbit and Human Study2006

    • Author(s)
      Masamitsu Hatakenaka, MD, PhD, Hiroyasu Soeda, MD, Takashi Okafuji, MD, Hidetake Yabuuchi, MD, PhD, Satoshi Shiokawa, MD, PhD, Junji Nishimura, MD, PhD, Hiroshi Honda, MD, PhD
    • Journal Title

      Radiology 238, 2

      Pages: 650-657

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary

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Published: 2003-04-01   Modified: 2016-04-21  

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