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Clarification of recovery mechanism from chronic brain dysfunction and application to treatment-EEG and NIRS as tools to monitor of brain function-

Research Project

Project/Area Number 15500375
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Rehabilitation science/Welfare engineering
Research InstitutionPrefectural University of Hiroshima (2005)
Hiroshima Prefectual College of Health Sciences (2003-2004)

Principal Investigator

ISHIZAKI Fumiko  Prefectural University of Hiroshima, Faculty of Health and Welfare, Professor, 保健福祉学部, 教授 (60093572)

Co-Investigator(Kenkyū-buntansha) HARADA Toshihide  Hiroshima International University, Health Services Managements, Professor, 医療福祉学部, 教授 (60181020)
OZAWA Yoshiaki  Prefectural University of Hiroshima, Faculty of Health and Welfare, Professor, 保健福祉学部, 講師 (60280210)
IMAIZUMI Satoshi  Prefectural University of Hiroshima, Faculty of Health and Welfare, assist Professor, 保健福祉学部, 教授 (80122018)
MIYAGUTI Hideki  Hiroshima University, Medical Sciences, Professor, 医学部, 教授 (00290552)
YOSHIDA Akira  Prefectural University of Hiroshima, Faculty of Health and Welfare, Professor, 保健福祉学部, 教授 (30136113)
Project Period (FY) 2003 – 2005
Project Status Completed (Fiscal Year 2005)
Budget Amount *help
¥3,600,000 (Direct Cost: ¥3,600,000)
Fiscal Year 2005: ¥800,000 (Direct Cost: ¥800,000)
Fiscal Year 2004: ¥700,000 (Direct Cost: ¥700,000)
Fiscal Year 2003: ¥2,100,000 (Direct Cost: ¥2,100,000)
Keywordspost-stroke / chronic brain dysfunction / functional recovery / rehabilitation / NIRS / brain circulation / EEG spectrum analysis / longitudinal study / 縦断的検討 / 脳血管障害慢性期 / 脳機能回復 / 脳波周波数帯域別マッピング / 慢性期脳血管障害 / 高次脳機能障害 / 脳波マッピング / 光トポグラフィ / P300
Research Abstract

Although patients recover from chronic brain dysfunction, the mechanisms of the underlying restorative process remain unclear. We examined the recovery mechanisms of brain function in stroke patients in the long term. The subjects were 30 patients (mean age at examination was 61.2 years old; on average 20.9 months post-stroke). While evaluating the clinical neurological findings, the effect and recovery process of rehabilitation were evaluated by. EEG, and brain, regional circulation was measured with near-infrared spectroscopy (NIRS) (Hitachi, ETG-100). EEG by electroencephalograph SYNAFIT 2514 (NEC) was examined 3.9 times on average during 52.6 months. The brain circulation change in both parietal-temporal regions was measured in 17 subjects (average age, 59 years old) with the NIRS method. We investigated cerebral circulation using posture conversion task and memory tasks, name and recall of objects and modified methods of Miyake memory tests. On EEG, although slow-wave elements were distributed in both sides of the brain on initial measurement, the frequency of the appearance of slow-wave elements was high on the lesion side of the brain. With progress, the distribution of the slow-wave elements on the healthy side decreased and the α-wave element gradually appeared. Improved EEG pattern related to a good outcome of the clinical prognosis. NIRS indicated that total Hb levels on both sides of the brain increased with the tasks, but the changes of brain circulation by the tasks were different depending on individual patients. It was speculated that activating the healthy side of the brain is necessary for the recovery of brain function. Also, devising rehabilitation for each patient is necessary for the recovery of brain function.

Report

(4 results)
  • 2005 Annual Research Report   Final Research Report Summary
  • 2004 Annual Research Report
  • 2003 Annual Research Report
  • Research Products

    (26 results)

All 2006 2005 2004 2003

All Journal Article (26 results)

  • [Journal Article] インターベンション時代の脳卒中学(改訂第2版)-超急性期から再発予防まで-2006

    • Author(s)
      原田俊英, 山岡和子, 石崎文子 他
    • Journal Title

      日本臨床 64・増刊号7

      Pages: 222-234

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Gene polymorphism in cerebrovascular disease.2006

    • Author(s)
      Harada T, Yamaoka K, Ishizaki F, et al.
    • Journal Title

      Nippon Rinsho 64(suppl 7)

      Pages: 222-234

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] 脳血管障害慢性期における脳機能回復の検証(会議録)2006

    • Author(s)
      石崎文子, 小澤由嗣, 今泉 敏, 近村千穂, 原田俊英, 山田 徹
    • Journal Title

      人間と科学 6・1

      Pages: 149-149

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Changes in plasma IL-13 in patients with acute cerebral infarction2005

    • Author(s)
      Cheng W, Harada T, Ishizaki F, et al.
    • Journal Title

      Int Med J 12・1

      Pages: 33-35

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] 脳血管障害慢性期の脳波周波数帯域別マッピングの経過と臨床像の比較検討2005

    • Author(s)
      石崎文子, 原田俊英, 近村千穂 他
    • Journal Title

      臨床神経学 45・12

      Pages: 1092-1092

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] アルツハイマー型痴呆ならびに血管性痴呆の診断・評価尺度について-4痴呆症例の臨床的検討-2005

    • Author(s)
      坪井敬子, 原田俊英, 大谷晴美 他
    • Journal Title

      診療と新薬 42・5

      Pages: 472-477

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] 看護における認知症の評価尺度に関する検討-4事例に試行して-2005

    • Author(s)
      坪井敬子, 原田俊英
    • Journal Title

      広島国際大学看護学ジャーナル 3

      Pages: 31-39

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Study on Relation between. EEG spectrum analysis and recovery of chronic brain dysfunction in post-stroke patients.2005

    • Author(s)
      Ishizaki F, Harada T, Cikamura C, et al.
    • Journal Title

      Clin Neurol 45(12)

      Pages: 1092-1092

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Diagnosis and assessment scale of Alzheimer's disease and dementia -evaluation of dementia in four cases-.2005

    • Author(s)
      Tsuboi K, Harada T, Ohtani H et al.
    • Journal Title

      Med Cons New-Remed 42(5)

      Pages: 472-477

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Assessment of dementia in nursing by using scales-evaluation in four patients with dementia.2005

    • Author(s)
      Tsuboi K, Harada T
    • Journal Title

      Nursing J Hiroshima International University 3

      Pages: 31-39

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] 光トポグラフィーによる頭部外傷患者の機能評価(会議録)2005

    • Author(s)
      原田薫雄, 神原淳, 石崎文子, 原田俊英
    • Journal Title

      リハビリテーション医学 42・supp1

    • Related Report
      2005 Annual Research Report
  • [Journal Article] アルツハイマー型痴呆ならびに血管性痴呆の診断・評価尺度について 4痴呆症例の臨床的検討2005

    • Author(s)
      坪井敬子, 原田俊英, 大谷晴美, 松田千絵, 藤原千寿子, 古川義紀, 石崎文子
    • Journal Title

      診療と新薬 42・5

      Pages: 472-477

    • Related Report
      2005 Annual Research Report
  • [Journal Article] 脳血管障害慢性期の脳波周波数マッピングの経過と臨床像の比較(会議録)2005

    • Author(s)
      石崎文子, 原田俊英, 近村千穂, 小澤由嗣, 山田 徹
    • Journal Title

      臨床神経学 45・12

      Pages: 1092-1092

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Study on relation between hypertension and the function of nitric oxide as the messenger2004

    • Author(s)
      Wu X, Li Y, Harada T, Ishizaki F, et al.
    • Journal Title

      Int Med J 11・2

      Pages: 115-117

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] An analysis of apolipoprotein E polymorphism in aged patients with vascular dementia.2004

    • Author(s)
      Wu X, Cheng W, Harada T, et al.
    • Journal Title

      Int Med J 11・4

      Pages: 291-293

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Study on relation between hypertension and the function of nitric oxide as the messenger.2004

    • Author(s)
      Wu X, Li Y, Harada T, Ishizaki F, et al.
    • Journal Title

      Int Med J 11(2)

      Pages: 115-117

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] An analysis of apolipoprotein E polymorphism in aged patients with vascular dementia2004

    • Author(s)
      Wu X, Cheng W, Harada T, et al.
    • Journal Title

      Int Med J 11(4)

      Pages: 291-293

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Changes in plasma IL-13 in patients with acute cerebral infarction.2004

    • Author(s)
      Cheng W, Haiada T, Ishizaki F, et al.
    • Journal Title

      Int Med J 12(1)

      Pages: 33-35

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] 慢性期脳血管障害における記憶課題の脳循環動態への影響-光トポグラフィでの検討-2004

    • Author(s)
      石崎文子, 小澤由嗣, 原田薫雄, 今泉敏, 原田俊英, 松本朋子, 岡崎正典
    • Journal Title

      臨床神経学 44・12

      Pages: 1103-1103

    • Related Report
      2004 Annual Research Report
  • [Journal Article] 中枢神経患者における光トポグラフィによる脳循環動態の検討2004

    • Author(s)
      石崎文子, 小澤由嗣, 原田薫雄, 今泉敏, 原田俊英, 松本朋子, 岡崎正典
    • Journal Title

      臨床神経学 44・12

      Pages: 1103-1103

    • Related Report
      2004 Annual Research Report
  • [Journal Article] 音声学的対立を利用した単語明瞭度評価法(日本語版)の試み2003

    • Author(s)
      小澤由嗣, 城本修, 石崎文子他
    • Journal Title

      音声言語医学 44・2

      Pages: 119-130

    • NAID

      10010736506

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Effect of acupuncture on autonomic nervous function such as finger blood flow and sweat response in healthy volunteers.2003

    • Author(s)
      Cheng W, Harada T, Ishizaki F, et al.
    • Journal Title

      Int Med J 10・2

      Pages: 113-117

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Aged with dextrocardia.2003

    • Author(s)
      Harada T, Ishizaki F, Cheng W, et al.
    • Journal Title

      Int Med J 10・3

      Pages: 205-207

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Word intelligibility testing using phonetic contrasts for Japanese speakers with articulation disorders.2003

    • Author(s)
      Ozawa Y, Shiromoto 0, Ishizaki F, et al.
    • Journal Title

      Jpn J Logop Phoniatr 44(2)

      Pages: 119-130

    • NAID

      10010736506

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Effect of acupuncture on autonomic nervous function such as finger blood flow and sweat response in healthy volunteers.2003

    • Author(s)
      Cheng W, Harada T, Ishizaki F, et al.
    • Journal Title

      Int Med J 10(2)

      Pages: 113-117

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Aged with dextrocardia.2003

    • Author(s)
      Harada T, Ishizaki F, Cheng W, et al.
    • Journal Title

      Int Med J 10(3)

      Pages: 205-207

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary

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Published: 2003-04-01   Modified: 2016-04-21  

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