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Research into the effects of sport activity on platelet and endothelial function and on development of atherosclerosis in children.

Research Project

Project/Area Number 15500431
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Sports science
Research InstitutionUniversity of Tsukuba

Principal Investigator

HORIGOME Hitoshi  University of Tsukuba, Graduate School of Comprehensive Human Sciences, Assistant Professor, 大学院・人間総合科学研究科, 講師 (50241823)

Co-Investigator(Kenkyū-buntansha) HIRAMATSU Yuji  University of Tsukuba, Graduate School of Comprehensive Human Science, Associate professor, 大学院・人間総合科学研究科, 助教授 (30302417)
TANAKA Kiyoji  University of Tsukuba, Graduate School of Comprehensive Human Science, Professor, 大学院・人間総合科学研究科, 教授 (50163514)
Project Period (FY) 2003 – 2005
Project Status Completed (Fiscal Year 2005)
Budget Amount *help
¥3,700,000 (Direct Cost: ¥3,700,000)
Fiscal Year 2005: ¥600,000 (Direct Cost: ¥600,000)
Fiscal Year 2004: ¥900,000 (Direct Cost: ¥900,000)
Fiscal Year 2003: ¥2,200,000 (Direct Cost: ¥2,200,000)
Keywordssports medicine / pediatrics / adult disease / atherosclerosis / platelet function / coagulofibrinolysis / 動脈硬化症
Research Abstract

Introduction : Adult disease, including atherosclerosis, has its origins in childhood. Endothelial and platelet functions are implicated in progression of atherosclerosis. Although weight control is important for prevention of adult disease, changes in endothelial and platelet function due to growth or to exercise have not been clarified. Moreover, effective diet and/or exercise intervention from childhood has not been established. We investigated platelet activity and coagulofibrinolytic proteins that enhance endothelial function in children, adults and patients with cyanotic congenital heart disease (CCHD). We also assessed the effect of weight reduction on these markers.
Materials and Method : 1.Plasma levels of soluble P-selectin, beta-thromboglobulin (beta-TG), platelet factor 4 (PF4), protein C and protein S in CCHD patients were measured. 2.Diurnal changes (9:00 am vs 4:00 pm) in plasminogen activator inhibitor-1 (PAI-1) activity and tissue-type plasminogen activator (t-PA) antig … More en levels in CCHD patients were evaluated. 3.Effects of weight reduction on platelet derived microparticles (PMP) released from activated platelets, PAI-1 activity and t-PA antigen were compared between 12-week calorie restricted diet with or without aerobic exercise in obese adults.
Results : 1.Plasma levels of P-selectin, beta-TG,PF4 were significantly high, and those of free protein S antigen and protein C activity were significantly low in CCHD patients compared with acyanotic patients. P-selectin and beta-TG correlated positively, and protein S and protein C correlated negatively with hematocrit. 2.Morning increase of PAI-1 activity and t-PA antigen levels was observed in CCHD patients. Plasma levels of t-PA antigen at 9 am and 4 pm were higher in CCHD patients than those in acyanotic patients, and correlated positively with the levels of erythrocytosis. 3.PMP,PAI-1 activity and t-PA antigen values were elevated in obese adults in comparison with non-obese adults, and these three parameters correlated with body mass index (BMI). The intervention significantly reduced PMP,PAI-1 and t-PA antigen levels. There was a significant correlation between percentages of change in PMP values and those in BMI, fat tissue mass.
Conclusion : Weight reduction appears to be essential for prevention of adult disease, through improvement of endothelial and platelet functions. There were platelet and coagulofibrinolytic abnormalities in CCHD patients who were exposed to chronic hypoxia. Strenuous exercise would induce transient tissue hypoxia. Establishment of appropriate diet and exercise therapies for age could contribute to prevention of adult disease from childhood. Less

Report

(4 results)
  • 2005 Annual Research Report   Final Research Report Summary
  • 2004 Annual Research Report
  • 2003 Annual Research Report

Research Products

(25 results)

All 2006 2005 2004 2003 Other

All Journal Article Publications

  • [Journal Article] Standardization of the PQRST waveform and analysis of arrhythmias in the fetus using vector magnetocardiography2006

    • Author(s)
      Horigome H, et al.
    • Journal Title

      Pediatr Res. 59(1)

      Pages: 121-125

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Magnetic resonance imaging of the brain and hematologic profile in adult cyanotic congenital heart disease without stroke.2006

    • Author(s)
      Horigome H, et al.
    • Journal Title

      Heart 92(2)

      Pages: 263-265

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] A pitfall in ligation of intrahepatic shunting after fontan type operation.2006

    • Author(s)
      Ikeda A, et al.
    • Journal Title

      Asian Cardiovasc Thorac Ann. 14(1)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Impact of weight reduction on production of platelet-derived microparticles and fibrinolytic parameters in obesity.2006

    • Author(s)
      Murakami T, et al.
    • Journal Title

      Thromb Res. (In press)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Replacement of the common atrioventricular valve with floating annuloplasty in a patient with univentricular physiology.2006

    • Author(s)
      Sato M, et al.
    • Journal Title

      Jpn Thorac Cardiovasc Surg. 54(2)

      Pages: 85-87

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Standardization of the PQRST waveform and analysis of arrhythmias in the fetus using vector magnetocardiography.2006

    • Author(s)
      Horigome H, et al.
    • Journal Title

      Pediatr Res. 59(1)

      Pages: 121-125

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Standardization of the PQRST waveform and analysis of arthythmias in the fetus using vector magnetocardiography2006

    • Author(s)
      Horigome H, et al.
    • Journal Title

      Pediatr Res. 59(1)

      Pages: 121-125

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Magnetic resonance imaging of the brain and hematologic profile in adult cyanotic congenital heart disease without stroke.2006

    • Author(s)
      Horigogme H et al.
    • Journal Title

      Heart 92(2)

      Pages: 263-265

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Impact of weight reduction on production of platelet-derived microparticles and fibrinolytic parameters in obesity.2006

    • Author(s)
      Murakami T et al.
    • Journal Title

      Thromb Res. (In press)

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Fatal eosinophilic heart disease in a child with neurofibromatosis-1 complicated by acute lymphoblastic leukemia.2005

    • Author(s)
      Horigome H, et al.
    • Journal Title

      Heart Vessels. 20(3)

      Pages: 120-122

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Annual Research Report 2005 Final Research Report Summary
  • [Journal Article] Successful management of supraventricular tachycardia in a fetus using fetal magnetocardiography.2005

    • Author(s)
      Abe K, et al.
    • Journal Title

      Fetal Diagn Ther. 20(5)

      Pages: 459-62

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Fatal eosinophilic heart disease in a child with neurofibromatosis-1 complicated by acute lympho blastic leukemia.2005

    • Author(s)
      Horigome H, et al.
    • Journal Title

      Heart Vessels. 20(3)

      Pages: 120-122

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Heart rate variability and ambulatory blood pressure monitoring in young patients with hypertrophic cardiomyopathy.2004

    • Author(s)
      Yanagi S, et al.
    • Journal Title

      Circ J. 68(8)

      Pages: 757-762

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Heart rate variability and ambulatory blood pressure monitoring in young patients with hypertrophic cardiomyopathy.2004

    • Author(s)
      Yanagi S, et al.
    • Journal Title

      Circulation Journal 68(8)

      Pages: 757-762

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Increased plasma level of endothelin-1 following percutaneous balloon dilatation of aortic coarctation in children.2003

    • Author(s)
      Horigome H, et al.
    • Journal Title

      Eur J Pediatr. 162(7-8)

      Pages: 543-544

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Detection of repolarization abnormalities in patients with cardiomyo-pathy using current vector mapping technique on magnetocardiogram.2003

    • Author(s)
      Shiono J. et al.
    • Journal Title

      Int J Cardiovasc Imaging. 19(2)

      Pages: 163-70

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Electrocardiographic changes in patients with cardiac rhabdomyomas associated with tuberous sclerosis.2003

    • Author(s)
      Shiono J. et al.
    • Journal Title

      Cardiol Young. 13(3)

      Pages: 258-63

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Who is at risk for cardiac events in young patients with long QT syndrome?2003

    • Author(s)
      Yoshinaga M. et al.
    • Journal Title

      Circ J. 67(12)

      Pages: 1007-10012

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Ventricular fibrillation during anesthesia in association with J waves in the left precordial leads in a child with coarctation of the aorta.2003

    • Author(s)
      Horigome H, et al.
    • Journal Title

      J Electrocardiol. 36(4)

      Pages: 339-343

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Palliative open heart surgery in an infant with factor VII deficiency.2003

    • Author(s)
      Tokunaga C, et al.
    • Journal Title

      Annals Thoracic Surgery 76(6)

      Pages: 2093-2094

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary 2004 Annual Research Report
  • [Journal Article] Soluble P-selectin and thrombomodulin-protein C-Protein S pathway in cyanotic congenital heart disease with secondary erythrocytosis.2003

    • Author(s)
      Horigome H, et al.
    • Journal Title

      Thromb Res. 112(4)

      Pages: 223-227

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Detection of repolarization abnormalities in patients with cardiomyo-pathy using current vector mapping technique on magnetocardiogram2003

    • Author(s)
      Shiono J. et al.
    • Journal Title

      Int J Cardiovasc Imaging. 19(2)

      Pages: 163-170

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Soluble P-selectin and thrombomodulin-protein C-Protein S pathway in cyanotic congenital heart disease with secondary erythrocytosis.2003

    • Author(s)
      Horigome H, et al.
    • Journal Title

      Thrombosis Research 112(4)

      Pages: 223-227

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Who is at risk for cardiac events in young patient with long QT syndrome?2003

    • Author(s)
      Yoshinaga M, et al.
    • Journal Title

      Circulation Journal 67(12)

      Pages: 1007-1012

    • Related Report
      2004 Annual Research Report
  • [Publications] Horigome H, et al.: "P-selectin and thrombomodulin-protein C-protein S pathway in cyanotic congenital heart disease with secondary erythrocytosis"Thrombosis Research. 112(4). 223-227 (2003)

    • Related Report
      2003 Annual Research Report

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Published: 2003-03-31   Modified: 2016-04-21  

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