| Co-Investigator(Kenkyū-buntansha) |
SHIMOMITSU Teruichi Tokyo Medical University, Department of Preventive Medicine, Professor, 医学部, 教授 (90206243)
ABE Akihisa Tokyo Medical University, Department of Biochemistry, Associate, 医学部, 助教 (30201289)
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| Budget Amount *help |
¥3,300,000 (Direct Cost: ¥3,300,000)
Fiscal Year 2006: ¥500,000 (Direct Cost: ¥500,000)
Fiscal Year 2005: ¥500,000 (Direct Cost: ¥500,000)
Fiscal Year 2004: ¥600,000 (Direct Cost: ¥600,000)
Fiscal Year 2003: ¥1,700,000 (Direct Cost: ¥1,700,000)
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| Research Abstract |
We investigated the changes in various physiological factors, blood lactate, urinary NOx, urinary bicarbonate and urinary pH during quantitative and heavy exercise (local and systemic repetition exercises) and after the termination of the exercise, in healthy male adults. Furthermore, we studied the effects of cooling-down exercise on changes in these physiological parameters after the termination of heavy exercises. Based on these results, dynamics of blood NO and bicarbonate, changes in blood and erythrocytic pH were deduced, and physiological significance and the significance in exercise medicine of these parameters were inspected.As a result, it was found that urinary bicarbonate increased within 3 hours after the termination of exercises, accompanying with the increment of urinary pH. These results were explained by the facts that blood lactate accumulated during heavy exercises was metabolized to carbon dioxide, which was further metabolized to bicarbonate in the blood. Bicarbonate was finally excreted into the urine. As these reactions proceed, a large amount of hydrogen ion was left in the erythrocytes causing decreased oxygen affinity of hemoglobin, and finally inducing systemic cyanosis. These processes could be considered to be associated with fatigue after heavy exercise. When cooling-down exercise was introduced, no increase of urinary bicarbonate was observed, suggesting that the internal circumstances in the body would be improved by cooling-down. Present study suggested that the decrease of intraerythrocytic pH, which is easily deduced from urinary bicarbonate, might be important as a fatigue factor after heavy exercise.
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