| Budget Amount *help |
¥3,800,000 (Direct Cost: ¥3,800,000)
Fiscal Year 2004: ¥1,200,000 (Direct Cost: ¥1,200,000)
Fiscal Year 2003: ¥2,600,000 (Direct Cost: ¥2,600,000)
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| Research Abstract |
In this study, the effects of treatment using a weight reduction program on anthropometry, fitness, and metabolic factors were evaluated in 40 obese children. The body weight and relative weight were significantly improved by the weight reduction program, but no changes in the lean body mass were observed. The subcutaneous fat area significantly decreased from 250.6 cm^2 to 138.8 cm^2. The visceral fat area also decreased significantly from 50.5 cm^2 to 32.4 cm^2, showing a normal abdominal fat distribution. The total insulin area determined by an oral glucose tolerance test significantly decreased following the weight reduction program, and insulin-resistance improved. These changes were highly correlated with the changes in the visceral fat area in the obese boys (r=0.743), suggesting that accumulation of visceral fat caused insulin-resistance. However, in the girls, no correlation was observed. An adipocytokine, leptin, and highly sensitive CRP significantly decreased with the reduc
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tion of body weight, while adiponectine increased. In particular, the increase in the adiponectine level, which is related to the prevention of arteriosclerosis in the future, was significantly correlated with the decrease in visceral fat, suggesting the importance of reduction of visceral fat. With the decreases in the relative weight and visceral fat, the metabolic abnormalities improved. The incidence of metabolic syndrome(MS) decreased from 15.3% to 2.5% following the weight reduction program. Endurance parameters, PWC150 and VO_2max, significantly increased. Multi-regression analysis of the relationship between the MS components and endurance using PWC150 demonstrated that the changes in PWC150 were independent of those in the relative weight and abdominal fat distribution, but were correlated with the systolic blood pressure and HDL-C. These results suggested that to improve MS in obese children by reduction of the body weight, not diet treatment alone, but a combination of diet treatment and exercise treatment is important. Less
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