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Mechanism of the prevention of the arteriosclerosis by exercise : Focused on the oxidative stress protective mechanism

Research Project

Project/Area Number 15500500
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Applied health science
Research InstitutionUniversity of Occupational Health and Environmental Health

Principal Investigator

IKEDA Masaharu  University of Occupational Health and Environmental Health, Institute of Industrial Ecological Sciences, Professor, 産業生態科学研究所, 教授 (40078770)

Co-Investigator(Kenkyū-buntansha) NANRI Hiroki  Seinan Women's College, Department of Health and Welfare, Professor, 保健福祉学部, 教授 (80150415)
OHTA Masanori  University of Occupational Health and Environmental Health, Institute of Industrial Ecological Sciences, Research Associate, 産業生態科学研究所, 助手 (70341526)
Project Period (FY) 2003 – 2005
Project Status Completed (Fiscal Year 2005)
Budget Amount *help
¥3,700,000 (Direct Cost: ¥3,700,000)
Fiscal Year 2005: ¥900,000 (Direct Cost: ¥900,000)
Fiscal Year 2004: ¥900,000 (Direct Cost: ¥900,000)
Fiscal Year 2003: ¥1,900,000 (Direct Cost: ¥1,900,000)
KeywordsLifestyle Modification / Exercise / Arteriosclerosis / Oxidative stress / Nitric oxide / NO Bioavailability / DNA damage / 生活習慣病 / 運動 / 一酸化窒素(NO) / NO biovailability / EC(細胞外)-SOD / 脈波伝搬速度 / HOMA指数 / 酸化ストレス / 心血管危険因子 / 過酸化脂質 / NO / Nitrotyrosine / Peroxynitrite / TBARS / 8-ヒドロキシグアニン
Research Abstract

The aim of this study was to investigate the mechanism of the effects of the aerobic exercise on arteriosclerosis prevention from the viewpoint of oxygen stress and its protective mechanism.
In this study, we investigate the mechanism of the effects of the aerobic exercise on arteriosclerosis prevention from the viewpoint of oxygen stress and its protective mechanism.
Results were as follows ;
1.As a result of lifestyle modification, it was shown that the oxidative stress to the body was significantly influenced by an oxidative stress defense system, age, blood pressure, and BMI, and aerobic exercise reduced the oxidative stress.
2.The state of the oxidative stress before intervention, and urine nitric oxide level and maximum oxygen uptake were involved in the difference in the blood lowering effect by lifestyle modification, and blood pressure reduction by lifestyle modification resulted in improving other cardiovascular risks.
3.Blood pressure, BMI, lipid metabolism, insulin resistance, and lipid peroxidation were shown to improve after lifestyle modification. Nitric oxide(NO) biological availability was considered to contribute, in part, to hypotensive effects by lifestyle modification including exercise..
4.Summation of cardiovascular risk factors (multiple risk factor) showed the effect on the increase in the severity of each risk factor and the synergistic effect on the increase in an cardiovascular risk. Severity of each risk factor was improved and the number of risk factors were reduced by participation in lifestyle modification program.
5.Acute and chronic exercise prevented oxidative DNA damage by stimulating the nucleotide sanitizing mechanism and it was suggested that continuous aerobic exercise is effective for prevention of oxidative DNA damage.

Report

(4 results)
  • 2005 Annual Research Report   Final Research Report Summary
  • 2004 Annual Research Report
  • 2003 Annual Research Report
  • Research Products

    (32 results)

All 2006 2005 2004 2003 Other

All Journal Article (22 results) Book (2 results) Publications (8 results)

  • [Journal Article] Hindlimb unloading decreases thioredoxin-related antioxidant proteins and increases thioredoxin-binding protein-2 in rat skeletal muscle.2006

    • Author(s)
      matsushima, Y, Nanri, H, Nara, S, Okufuji, T, Ohta, M, Hachisuka, Ikeda, M
    • Journal Title

      Free Radical Research (in press)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Hindlimb unloading decreases thioredoxin-related antioxidant proteins and increases thioredoxin-binding protein-2 in rat skeletal muscle.2006

    • Author(s)
      Matsushima, Y, Nanri, H, Nara, S, Okufuji, T, Ohta, M, Hachisuka, Ikeda, M.
    • Journal Title

      Free Radical Research (in press)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Effect of Lifestyle Modification on Worker's Job Satisfaction through the Collaborative Utilization of Community-based Health Promotion Program.2006

    • Author(s)
      Ohta, M, Takigami, C, Ikeda, M.
    • Journal Title

      International Congress Series (in press)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Hindlimb unloading decreases thioredoxin-related antioxidant proteins and increases thioredoxin-binding protein-2 in rat skeletal muscle.2006

    • Author(s)
      Matsushima, Y., et al.
    • Journal Title

      Free Radical Research (in press)

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Effect of Lifestyle Modification on Worker's Job Satisfaction through the Collaborative Utilization of Community-based Health Promotion Program.2006

    • Author(s)
      Ohta, M., et al.
    • Journal Title

      International Congress Series (in press)

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Blood pressure-lowering effects of lifestyle modification : possible involvement of nitric oxide bioavailability.2005

    • Author(s)
      Ohta, M, Nanri, H, Matsushima, Y, Sato, Y, Ikeda, M
    • Journal Title

      Hypertension Research 28

      Pages: 779-786

    • NAID

      10018366993

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Effect of Lifestyle Modification on Worker's Job Satisfaction through the Collaborative Utilization of Community-based Health Promotion Program.2005

    • Author(s)
      Ohta, M, Nanri, H, Matsushima, Y, Sato, Y, Ikeda, M.
    • Journal Title

      Hypertension Research, 28

      Pages: 779-786

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Blood pressure-lowering effects of lifestyle modification : possible involvement of nitric oxide bioavailability.2005

    • Author(s)
      Ohta, M., et al.
    • Journal Title

      Hypertension Research 28

      Pages: 779-786

    • NAID

      10018366993

    • Related Report
      2005 Annual Research Report
  • [Journal Article] 健康づくりと生産性、休業および労働適応能力について2005

    • Author(s)
      池田 正春, ら
    • Journal Title

      産業医学レビュー 18・1

      Pages: 1-19

    • NAID

      40006771794

    • Related Report
      2005 Annual Research Report
  • [Journal Article] 運動療法を介した個別管理と集団管理;どのような処方が好ましいか -循環器疾患の危険因子を中心に-2005

    • Author(s)
      池田 正春
    • Journal Title

      循環プラス 5・7

      Pages: 1-6

    • Related Report
      2005 Annual Research Report
  • [Journal Article] The Effect of Lifestyle Modification on Physical Fitness and Work Ability in Different Workstyles.2004

    • Author(s)
      Ohta, M., Okufuji, T., Matsushima, Y., Ikeda, M.
    • Journal Title

      J UOEH 26(4)

      Pages: 411-421

    • NAID

      110001260261

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] The Effect of Lifestyle Modification on Physical Fitness and Work Ability in Different Workstyles2004

    • Author(s)
      Ohta, Masanori
    • Journal Title

      UOEH 26・4

      Pages: 411-421

    • NAID

      110001260261

    • Related Report
      2004 Annual Research Report
  • [Journal Article] 生活習慣の修正-その効果と限界:身体活動2004

    • Author(s)
      奥藤 達哉
    • Journal Title

      血圧 11・2

      Pages: 146-150

    • Related Report
      2004 Annual Research Report
  • [Journal Article] 余暇の過ごし方アドバイスについて教えて下さい2004

    • Author(s)
      太田 雅規
    • Journal Title

      治療 86・3

      Pages: 590-592

    • Related Report
      2004 Annual Research Report
  • [Journal Article] 働く人々のための健康づくりが生産性、労働適応能力、休業に及ぼす効果について2004

    • Author(s)
      太田 雅規
    • Journal Title

      産業医学ジャーナル 27・4

      Pages: 63-67

    • Related Report
      2004 Annual Research Report
  • [Journal Article] 高血圧予防・治療のための生活習慣修正の実践指導の充実を2004

    • Author(s)
      池田 正春
    • Journal Title

      高血圧 11・8

      Pages: 874-874

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Enhancement of Mitochondria Oxidative Stress and Up-regulation of Antioxidant Protein Peroxiredoxin III/SP-22 in the Mitochondria of Human Pre-eclamptic Placentae2003

    • Author(s)
      Shibata, E., Nanri, H., Ejima, K., Araki, M., Fukuda, J., Yoshimura, K., Toki, N., Ikeda, M., Kashimura, M.
    • Journal Title

      Placenta 24

      Pages: 698-705

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Involvement of thioredoxin-related antioxidant systems in the defence of cadmium-induced oxidative systems.2003

    • Author(s)
      Nanri H., Fernando MR., Ikeda, M
    • Journal Title

      J. UOEH 25(supl)

      Pages: 71-80

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Increase of human MTH1 and decrease of 8-hydroxydeoxyguanosine in leukocyte DNA by acute and chronic exercise in healthy male subjects.2003

    • Author(s)
      Sato Y., Nanri H., Ohta, M., Kasai, H., Ikeda, M.
    • Journal Title

      Biochemical and Biophysical Research Communications 305(2)

      Pages: 333-338

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Enhancement of Mitochondria Oxidative Stress and Up-regulation of Antioxidant Protein Peroxiredoxin III/SP-22 in the Mitochondria of Human Pre-eclamptic Placentae2003

    • Author(s)
      Shibata, E., Nanri, H., Ejima, K., Araki, M., Fukuda, J., Yoshimura, K., Toki.N., Ikeda, M., Kashimura, M.
    • Journal Title

      Placenta 24

      Pages: 698-705

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Immunohistochemical study of the carotid body during acute hypoxia2003

    • Author(s)
      Ohtomo K., Hayashida, Y., Fukuhara K., Nanri H., Ikeda, M., Yoshizaki K.
    • Journal Title

      Adv Exp Med Biol 536

      Pages: 109-116

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Involvement of thioredoxin-related antioxidant systems in the defense of cadmium-induced oxidative systems.2003

    • Author(s)
      Nanri H., Fernando MR., Ikeda, M.
    • Journal Title

      J.UOEH 25(supp)

      Pages: 71-80

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Book] 高血圧診療のコツと落とし穴(島田和幸編)2004

    • Author(s)
      池田 正春
    • Total Pages
      243
    • Publisher
      中山書店
    • Related Report
      2004 Annual Research Report
  • [Book] 北九州市健康白書20032004

    • Author(s)
      舟谷 文男
    • Total Pages
      173
    • Related Report
      2004 Annual Research Report
  • [Publications] Shibata, E.: "Enhancement of Mitochondria Oxidative Stress and Up-regulation of Antioxidant Protein Peroxiredoxin III/SP-22 in the Mitochondria of Human Pre-eclamptic Placentae"Placentae. 1-8 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] 太田 雅規: "運動が血圧変動性ならびに臓器障害に及ぼす影響"血圧. 10・11. 1205-1210 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] 太田 雅規: "企業フィットネスにおけるトピックス:高齢者と企業フィットネス"臨床スポーツ医学. 20・5. 549-554 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Ohtomo, K: "Immunohistochemical study of the carotid body during acute hypoxia"Adv Exp Med Biol. 536. 109-116 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Nanri, H.: "Involvement of thioredoxin-related antioxidant systems in the defense of cadmium-induced oxidative systems."J.UOEH. 25・suppl. 71-80 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Sato, Y.: "Increase of human MTH1 and decrease of 8-hydroxydeoxyguanosine in leukocyte DNA by acute and chronic exercise in healthy male subjects."Biochemical and Biophysical Research Communications. 305・2. 333-338 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] 太田 雅規: "生活習慣修正指導の酸化ストレスに対する効果と日常生活活動量の関与について"研究助成論文集. 19. 43-50 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] 奥藤 達哉: "生活習慣の修正-その効果と限界 身体活動"血圧. 11・2. 34-38 (2004)

    • Related Report
      2003 Annual Research Report

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Published: 2003-04-01   Modified: 2016-04-21  

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