| Project/Area Number |
15500512
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
General human life sciences
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| Research Institution | Nara University of Education |
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Principal Investigator |
UCHIDA Emiko Nara University of Education, Professor, 教育学部, 教授 (10086019)
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| Co-Investigator(Kenkyū-buntansha) |
IKADA Yoshito Suzuka University of Medical Science, Professor, 医用工学部, 教授 (00025909)
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| Project Period (FY) |
2003 – 2005
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| Project Status |
Completed (Fiscal Year 2005)
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| Budget Amount *help |
¥3,700,000 (Direct Cost: ¥3,700,000)
Fiscal Year 2005: ¥800,000 (Direct Cost: ¥800,000)
Fiscal Year 2004: ¥900,000 (Direct Cost: ¥900,000)
Fiscal Year 2003: ¥2,000,000 (Direct Cost: ¥2,000,000)
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| Keywords | safety of clothing / a three-dimensional skin model / skin stimulant substance / contact dermatitis / Safety confirmation method / 3次元培養皮膚 |
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| Research Abstract |
Our study is aiming at establishing a safety level of the skin irritancy that remained in fiber with cultured human skin models by getting accumulation of detailed data about reaction of irritant contact dermatitis-causing substance to human skin. Test substances used in this study are formaldehyde, various kinds of surfactants, optical whitening agents, marketable softening agents, marketable deodorants, dry cleaning solvents, and disperse dyes. Main results are as follows.
1.The skin irritancy of anionic surfactant depends on the number of carbon of an alkyl group greatly, and on the range from 9 to 12 the skin irritancy shows positive. That of nonionic surfactant depends on the number of ethylene oxide and the number of carbon of an alkyl group greatly. Even in the low concentration range that of cationic surfactant shows positive.
2.The marketable antibacterial softening agents and deodorants show large skin irritancy.
3.The case of benzene onto the cotton fiber shows the highest skin irritancy and the second is acrylic fiber.
It is expected that cultured skin models will be very useful for purposes of predicting in vivo skin irritancy of chemicals and for studying mechanistic such irritancy.
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