Evaluation of Combined Toxic Potency of Xenobiotics and the Decreasing Effect of Edible Plants
| Project/Area Number |
15500545
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Eating habits, studies on eating habits
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| Research Institution | University of Shizuoka |
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Principal Investigator |
KINAE Naohide Univ. of Shizuoka, Sch. of Food & Nutr. Sci., Prof., 食品栄養科学部, 教授 (00046286)
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| Co-Investigator(Kenkyū-buntansha) |
MASUDA Shuichi Univ. of Shizuoka, Sch. of Food & Nutr. Sci., Assist. Prof., 食品栄養科学部, 助手 (40336657)
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| Project Period (FY) |
2003 – 2004
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| Project Status |
Completed (Fiscal Year 2004)
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| Budget Amount *help |
¥2,100,000 (Direct Cost: ¥2,100,000)
Fiscal Year 2004: ¥800,000 (Direct Cost: ¥800,000)
Fiscal Year 2003: ¥1,300,000 (Direct Cost: ¥1,300,000)
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| Keywords | mutagenicity / combined effect / nitroso compounds / antimutagenicity / tea catechin / comet assay / micronucleus test / goldfish / 変異原 / 発がん物質 / 複合作用 / コメットアッセイ |
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| Research Abstract |
A mixture of bisphenol A (BPA) and sodium nitrite was dissolved in acetate buffer (pH3.0) and incubated at 37℃ for 60 min, a new mutagens having hydroxyl and azo groups was isolated. When a mixture of morpholine and sodium nitrite was used, nitrosomorpholine (NMo) was produced. But the addition of tea extract decreased the mutagnnicity and the content of NMo. These data demonstrated the combined effects between environmental chemicals and sodium nitrite that is present in vegetables and saliva were observed.
By comparison of the genotoxicity of micronucleus test and comet assay using rodent or fish, goldfish was found to be a useful candidate as the experimental animal.
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Report
(3 results)
Research Products
(26 results)
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[Journal Article] Depressive symptoms are independently correlated with lipid peroxidation in a female population Comparison with vitamins and carotenoids2004
Author(s)
Tsuboi, Hirohito, Shimoi, Kayoko, Kinae, Naohide, Oguni, Itaro, Hori, Reiko, Kobayashi, Fumio
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Journal Title
Journal of psychosomatic resarch 56
Pages: 53-58
Description
「研究成果報告書概要(欧文)」より
Related Report
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[Journal Article] Distribution of 3-chloro-4-(dichloromethyl)-5-hydroxy-2(5H)-furanone(MX) in water Samples, and its chemical and genotoxic properties2004
Author(s)
Sugiyama, Chitose, Nakajima, Madoka, Iwamoto, Ken-ichi, Masuda, Shuichi, Oishi, Etsuo, Kinae, Naohide
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Journal Title
Journal of Japan Society on Water Environment Vol.27, No.6
Pages: 393-401
NAID
Description
「研究成果報告書概要(欧文)」より
Related Report
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[Journal Article] Genotoxicity of 2-[2-(acetylamino)-4-[bis(2-hydroxyethyl)amino]-5-methoxyphenyl]-5-amino-7-bromo-4-chloro-2H-benzotriazole (PBTA-6) and 4-amino-3,3'-dichloro-5,4'-dinitro-biphenyl (ADDB) in goldfish (Carassius auratus) using the micronucleus test and the comet assay2004
Author(s)
Masuda, Shuichi, Deguchi, Yuya, Masuda, Yumi, Watanabe, Tetsushi, Nukaya, Haruo, Terao, Yoshiyasu, Takamura, Takeji, Wakabayashi, Keiji, Kinae, Naohide
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Journal Title
Mutation Research 560
Pages: 33-40
Description
「研究成果報告書概要(欧文)」より
Related Report
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[Journal Article] Formation of a new mutagens, 2-(5-hydroxy-4, 6-dinitoroindolyl) ethanol, from the reaction of 5-hydroxytryptamine, nitrite and L-cysteine
Author(s)
Masuda, Shuichi, Tan, Hiromi, Terashima, Yumeko, Hashizume, Takashi, Kumazawa, Shigenori, Sugiyama, Yasumasa, Sugimoto, Osamu, Tanji, Ken-ichi, Nakayama, Tsutomu, Terao, Yoshiyasu, Wakabayashi, Keiji, Kinae, Naohide
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Journal Title
Mutation Research (in press)
Description
「研究成果報告書概要(欧文)」より
Related Report
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[Journal Article] Changes in the mutagenic and estrogenic activity of bisphenol A upon treatment with nitrite
Author(s)
Masuda, Shuichi, Terashima, Yumeko, Sano, Ayako, Kuruto, Ryoko, Sugiyama, Yasumasa, Shimoi, Kayoko, Tanji, Ken-ichi, Yoshioka, Hisashi, Terao, Yoshiyasu, Kinae, Naohide
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Journal Title
Mutation Research (in press)
Description
「研究成果報告書概要(欧文)」より
Related Report
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