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Species differences among mice, hamsters, rats and guinea pigs in PCB-induced alteration of serum thyroid hormone level

Research Project

Project/Area Number 15510058
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Risk sciences of radiation/Chemicals
Research InstitutionUniversity of Shizuoka

Principal Investigator

KATO Yoshihisa  University of Shizuoka, School of Pharmaceutical Sciences, Assistant Professor, 薬学部, 講師 (90161132)

Project Period (FY) 2003 – 2005
Project Status Completed (Fiscal Year 2005)
Budget Amount *help
¥3,400,000 (Direct Cost: ¥3,400,000)
Fiscal Year 2005: ¥800,000 (Direct Cost: ¥800,000)
Fiscal Year 2004: ¥1,000,000 (Direct Cost: ¥1,000,000)
Fiscal Year 2003: ¥1,600,000 (Direct Cost: ¥1,600,000)
Keywordspolychlorinated biphenyl / endocrine-disrupter / species difference / thyroid hormone / UDP-glucuronosyltransferase / tranthyretin / liver / transporter / グルクロン酸抱合体 / マウス / ラット / ハムスター / モルモット / サイロキシイン
Research Abstract

In the present study, we investigated the mechanism for the decrease in levels of serum thyroid hormones, especially thyroxine (T_4), by polychlorinated biphenyls (PCBs) such as Kanechlor-500 (KC500),2,2',4',5,5'-pentachlorobiphenyl (PentaCB), and 2,2',3',4',5,6-hexachlorobiphenyl (HexaCB), and studied species difference among mice, hamsters, rats, and guinea pigs in the PCB effect. Significant decrease in serum total T_4 level by KC500 was observed in all four species. On the other hand, there were differences in the level of decrease of serum total T_4 level by PentaCB and HexaCB. Differences in the level of hepatic methylsulfonyl-PCB and OH-PCB metabolites of KC500, PentaCB and HexaCB, which were thought to be associated with the PCB-toxic effects, did not necessarily correlate with the magnitude of decrease in serum total T_4 level. Likewise, the induction of CYP1A, CYP2B, CYP3A, iodothyronine deiodinase and UDP-glucuronosyltransferases (T_4-UDP-GT) toward T_4 by PCB did not necess … More arily correlate with the decrease in serum T_4 level in the animals used. In addition, the PCB-mediated decrease in serum total T_4 level in UGT1A-deficient Wistar rats (Gunn rats) occurred without an increase in hepatic T_4-UDP-GT activity. Further studies on transthyretin (TTR) and serum T_4-transpoter suggested that decrease in serum total T_4 level by PCB occurred not only by induction of T_4-UDP-GT but also by the alteration of levels of T_4-TTR binding and hepatic T_4-transporter. In addition, species difference in the decrease of serum total T_4 level was associated with various PCB-induced total effects, including induction of T_4-UDP-GT, decrease in T_4-TTR binding level, the increase of hepatic thyroid hormone transporter, and other thyroid function correlates. In conclusion, the present findings suggest that in the animals used, the PCB-induced decrease in serum T_4 level dose not occur only through increase in hepatic T_4-UDP-GT, and further suggest that in all four species, the PCB-mediated decrease occurs through the increased transportation of T_4 to the liver. Furthermore, the decrease in the binding of T_4 to serum TTR and hepatic hyperplasia might be attributed to the increase in the level of T_4 in the liver. Further studies are necessary for understanding the susceptibility toward a PCB-mediated decrease in serum T_4 level in animals including humans. Less

Report

(4 results)
  • 2005 Annual Research Report   Final Research Report Summary
  • 2004 Annual Research Report
  • 2003 Annual Research Report
  • Research Products

    (63 results)

All 2006 2005 2004 2003 Other

All Journal Article (55 results) Book (2 results) Publications (6 results)

  • [Journal Article] Monospecific antipeptide antibodies against human hepatic UDP-glucuronosyltransferase 1A subfamily (UGT1A) isoforms2006

    • Author(s)
      Shin-ichi Ikushiro
    • Journal Title

      Drug Metab.Pharmacokinet. 21

      Pages: 70-74

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Monospecific antipeptide antibodies against human hepatic UDP-glucuronosyltransferase 1A subfamily (UGT1A) isoforms.2006

    • Author(s)
      Shin-ichi Ikushiro
    • Journal Title

      Drug Metab.Pharmacokinet 21

      Pages: 70-74

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Decrease in serum thyroxine level by phenobarbital in rats is not necessarily dependent on increase in hepatic UDP-glucuronosyltransferase2005

    • Author(s)
      Yoshihisa Kato
    • Journal Title

      Drug Metab.Dispos. 33

      Pages: 1608-1612

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Annual Research Report 2005 Final Research Report Summary
  • [Journal Article] The decrease in level of serum thyroxine by 2,2',4,5,5'-pentachlorobiphenyl in rats and mice : No correlation with formation of methylsulfonyl metabolites2005

    • Author(s)
      Yoshihisa Kato
    • Journal Title

      Drug Metab.Dispos. 33

      Pages: 1661-1665

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Comparative metabolism of polychlorinated biphenyls and tissue distribution of persistent metabolites in rats, hamsters, and guinea pigs2005

    • Author(s)
      Koichi Haraguchi
    • Journal Title

      Drug Metab.Dispos. 33

      Pages: 373-380

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Annual Research Report 2005 Final Research Report Summary
  • [Journal Article] Species differences in the tissue distribution of catechol and methylsulphonyl metabolites of 2,4,5,2',5'-penta- and 2,3,4,2',3',6'-hexachlorobiphenyls in rats, mice, hamsters and guinea pigs2005

    • Author(s)
      Koichi Haraguchi
    • Journal Title

      Xenobiotica 35

      Pages: 85-96

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Annual Research Report 2005 Final Research Report Summary
  • [Journal Article] In vitro metabolism of 2,2',3,4',5,5',6-heptachlorobiphenyl (CB187) by liver microsomes from rats, hamsters and guinea pigs2005

    • Author(s)
      Chiho Ohta
    • Journal Title

      Xenobiotica 35

      Pages: 319-330

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Annual Research Report 2005 Final Research Report Summary
  • [Journal Article] 2,3,4,4',5-五塩素化ビフェニル(CB118)のモルモット肝ミクロゾームによる代謝2005

    • Author(s)
      太田千穂
    • Journal Title

      福岡医学雑誌 96

      Pages: 232-240

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] In vivo metabolism of 2,2',3,4',5,5',6- heptachlorobiphenyl (CB187) in guinea pigs2005

    • Author(s)
      Chiho Ohta
    • Journal Title

      Organohalogen Compd. 67

      Pages: 2343-2345

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Mechanistic study for the decrease in serum thyroxine level in PCB-treated mice2005

    • Author(s)
      Makiko Kubota
    • Journal Title

      J.Toxicol.Sci. 30

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Annual Research Report 2005 Final Research Report Summary
  • [Journal Article] Species difference among mice, hamsters, rats, and guinea pigs in phenobarbital-induced alteration of serum thyroxine level2005

    • Author(s)
      Rie Takiguchi
    • Journal Title

      J.Toxicol.Sci. 30

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Annual Research Report 2005 Final Research Report Summary
  • [Journal Article] Decrease in serum thyroxine level by phenobarbital in rats is not necessarily dependent on increase in hepatic UDP-glucuro-nosyltransferase.2005

    • Author(s)
      Yoshihisa Kato
    • Journal Title

      Drug Metab.Dispos. 33

      Pages: 1608-1612

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] The decrease in level of serum thyroxine by 2,2',4,5,5'-pentachlorobiphenyl in rats and mice : No correlation with formation of methylsulfonyl metabolites.2005

    • Author(s)
      Yoshihisa Kato
    • Journal Title

      Drug Metab.Dispos. 33

      Pages: 1661-1665

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Comparative metabolism of polychlorinated biphenyls and tissue distribution of persistent metabolites in rats, hamsters and, guinea pigs.2005

    • Author(s)
      Koichi Haraguchi
    • Journal Title

      Drug Metab.Dispos. 33

      Pages: 373-380

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Species differences in the tissue distribution of catechol and methyl-sulphonyl metabolites of 2,4,5,2',5'-penta-and 2,3,4,2',3',6'-hexachlorobiphenyl in rats, mice, hamsters and guinea pigs.2005

    • Author(s)
      Koichi Haraguchi
    • Journal Title

      Xenobiotica 35

      Pages: 85-96

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] In vitro metabolism of 2,2',3,4',5,5',6-heptachlorobiphenyl (CB187) by liver microsomes from rats, hamsters and guinea pigs.2005

    • Author(s)
      Chiho Ohta
    • Journal Title

      Xenobiotica 35

      Pages: 319-330

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Metabolism of 2, 3', 4, 4', 5-penta-chlorobiphenyl in guinea pig microsomes.2005

    • Author(s)
      Chiho Ohta
    • Journal Title

      Fukuoka Acta Medica 96

      Pages: 232-240

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] In vivo metabolism of 2,2',3,4',5,5',6-heptachlorobiphenyl (CB187) in guinea pigs.2005

    • Author(s)
      Chiho Ohta
    • Journal Title

      Organohalogen Compd. 67

      Pages: 2343-2345

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Mechanistic study for the decrease in serum thyroxine level in PCB-treated mice.2005

    • Author(s)
      Makiko Kubota
    • Journal Title

      J.Toxicol.Sci. 30

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Species difference among mice, hamsters, rats, and guinea pigs in phenobarbital-induced alteration of serum thyroxine level.2005

    • Author(s)
      Rie Takiguchi
    • Journal Title

      J Toxicol. Sci. 30

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] The decrease in level of serum thyroxine by 2,2',4,5,5'-pentachlorobiphenyl in rats and mice: No correlation with formation of methylsulfonyl metabolites2005

    • Author(s)
      Yoshihisa Kato
    • Journal Title

      Drug Metab.Dispos. 33

      Pages: 1661-1665

    • Related Report
      2005 Annual Research Report
  • [Journal Article] 2,3',4,4',5-五塩素化ビフェニル(CB118)のモルモット肝ミクロゾームによる代謝2005

    • Author(s)
      太田千穂
    • Journal Title

      福岡医学雑誌 96

      Pages: 232-240

    • Related Report
      2005 Annual Research Report
  • [Journal Article] In vivo metabolism of 2,2',3,4',5,5',6- heptachlorobiphenyl (CB 187) in guinea pigs2005

    • Author(s)
      Chiho Ohta
    • Journal Title

      Organohalogen Compd. 67

      Pages: 2343-2345

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Polychlorinated biphenyls (PCBs) exert thyroid hormone-like effects in the fetal rat brain but do not bind to thyroid hormone receptors2004

    • Author(s)
      Kelly J.Gauger
    • Journal Title

      Environ.Health Perspect. 112

      Pages: 516-523

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] A possible mechanism for decrease in serum thyroxine level by polychlorinated biphenyls in Wistar and Gunn rats2004

    • Author(s)
      Yoshihisa Kato
    • Journal Title

      Toxicol.Sci. 81

      Pages: 309-315

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary 2004 Annual Research Report
  • [Journal Article] Metabolism of polychlorinated biphenyls by Gunn rats : Identification and serum retention of catechol metabolites2004

    • Author(s)
      Koichi Haraguchi
    • Journal Title

      Chem.Res.Toxicol. 17

      Pages: 1684-1691

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary 2004 Annual Research Report
  • [Journal Article] PCB類による甲状腺ホルモンかく乱作用とその作用機構:動物種差2004

    • Author(s)
      加藤善久
    • Journal Title

      環境変異原研究 26

      Pages: 101-106

    • NAID

      10013956799

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary 2004 Annual Research Report
  • [Journal Article] Polychlorinated biphenylsによる血中サイロキシン濃度低下作用機構2004

    • Author(s)
      加藤善久
    • Journal Title

      Endocrine Disrupter News Letter 7

      Pages: 2-2

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary 2004 Annual Research Report
  • [Journal Article] In vitro metabolism of 2,2',3,4',5,5',6-heptachlorobiphenyl (CB187) with liver microsomes of rats, hamsters and guinea pigs2004

    • Author(s)
      Nobuyuki Koga
    • Journal Title

      Organohalogen Compd. 66

      Pages: 2882-2886

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary 2004 Annual Research Report
  • [Journal Article] Species difference among mice, hamsters, rats and guinea pigs in phenobarbital-induced alteration of serum thyroid hormone level2004

    • Author(s)
      Hiroshi Suzuki
    • Journal Title

      J.Toxicol.Sci. 29

      Pages: 399-399

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary 2004 Annual Research Report
  • [Journal Article] Mechanistic study for the decrease in serum thyroid hormone level in PCB-treated mice2004

    • Author(s)
      Mao Onishi
    • Journal Title

      J.Toxicol.Sci. 29

      Pages: 464-464

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary 2004 Annual Research Report
  • [Journal Article] Polychlorinated biphenyls (PCBs) exert thyroid hormone-like effects in the fetal rat brain but do not bind to thyroid hormone receptors.2004

    • Author(s)
      Kelly J.Gauger
    • Journal Title

      Environ. Health Perspect. 112

      Pages: 516-523

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] A possible mechanism for decrease in serum thyroxine level by polychlorinated biphenyls in Wistar and Gunn rats.2004

    • Author(s)
      Yoshihisa Kato
    • Journal Title

      Toxicol.Sci. 81

      Pages: 309-315

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Metabolism of poly-chlorinated biphenyls by Gunn rats : Identification and serum retention of catechol metabolites.2004

    • Author(s)
      Koichi Haraguchi
    • Journal Title

      Chem.Res.Toxicol. 17

      Pages: 1684-1691

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Species differences among mice, hamsters, rats and guinea pigs in PCB-induced alteration of serum thyroid hormone level.2004

    • Author(s)
      Yoshihisa Kato
    • Journal Title

      Environ.Mutagen Res. 26

      Pages: 101-106

    • NAID

      10013956799

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] In vitro metabolism of 2,2',3,4',5,5',6-heptachlorobiphenyl (CB187) with liver microsomes of rats, hamsters and guinea pigs.2004

    • Author(s)
      Nobuyuki Koga
    • Journal Title

      Organohalogen Compd. 66

      Pages: 2882-2886

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Species difference among mice, hamsters, rats and guinea pigs in phenobarbital-induced alteration of serum thyroid hormone level.2004

    • Author(s)
      Hiroshi Suzuki
    • Journal Title

      J Toxicol.Sci. 29

      Pages: 399-399

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Mechanistic study for the decrease in serum thyroid hormone level in PCB-treated mice.2004

    • Author(s)
      Mao Onishi
    • Journal Title

      J Toxicol.Sci. 29

      Pages: 464-464

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Polychlorinated biphenyls (PCBs) exert thyroid hormone-like effects in the fetal rat brain but do not bind to thyroid hormone receptors2004

    • Author(s)
      Kelly J.Gauger
    • Journal Title

      Environ.Health Perspect. 1124

      Pages: 516-523

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Effects of polychlorinated biphenyls, Kanechlor-500, on serum thyroid hormonelevels in rats and mice2003

    • Author(s)
      Yoshihisa Kato
    • Journal Title

      Toxicol.Sci. 72

      Pages: 235-241

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] 2、3、3'、4、4'-五塩素化ビフェニル(CB105)のハムスターにおける代謝2003

    • Author(s)
      古賀信幸
    • Journal Title

      福岡医学雑誌 94

      Pages: 174-182

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Species difference among mice, hamsters, rats and guinea pigs in Kanechlor-500-induced alterations of serum thyroid hormone level2003

    • Author(s)
      Yoshihisa Kato
    • Journal Title

      Organohalogen Compd. 64

      Pages: 316-319

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Species difference among mice, hamsters, rats and guinea pigs in 2,2',4',5,5'-pentachlorobiphenyl and 2,2',3',4',5,6-hexachlorobiphenyl-induced alterations of serum thyroid hormone level2003

    • Author(s)
      Yoshihisa Kato
    • Journal Title

      Organohalogen Compd. 64

      Pages: 332-335

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Species difference among mice, hamsters, rats, and guinea pigs in Kanechlor-500-induced alteration of serum thyroid hormone level2003

    • Author(s)
      Yoshihisa Kato
    • Journal Title

      J.Toxicol.Sci. 28

      Pages: 321-321

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Species difference among mice, hamsters, rats, and guinea pigs in 2,2',4',5,5'-pentachlorobiphenyl or 2, 2',3',4',5,6-hexachlorobiphenyl-induced alteration of serum thyroid hormone level2003

    • Author(s)
      Yoshihisa Kato
    • Journal Title

      J.Toxicol.Sci. 28

      Pages: 322-322

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Identification and tissue distribution of catechol metabolites of polychlorinated biphenyls in rodents dosed with Kanechlor 5002003

    • Author(s)
      Koichi Haraguchi
    • Journal Title

      Organohalogen Compounds 64

      Pages: 345-348

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Metabolism of 2,3,3',4,4'-pentachlorobiphenyl in hamsters2003

    • Author(s)
      Nobuyuki Koga
    • Journal Title

      Organohalogen Compounds 64

      Pages: 427-430

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Effects of polychlorinated biphenyls, Kanechlor-500, on serum thyroid hormone levels in rats and mice.2003

    • Author(s)
      Yoshihisa Kato
    • Journal Title

      Toxicol.Sci. 72

      Pages: 235-241

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Metabolism of 2,3,3',4,4'-pentachlorobiphenyl in hamsters.2003

    • Author(s)
      Nobuyuki Koga
    • Journal Title

      Fukuoka Acta Medica 94

      Pages: 174-182

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Species difference among mice, hamsters, rats and guinea pigs in Kanechlor-500-induced alterations of serum thyroid hormone level.2003

    • Author(s)
      Yoshihisa Kato
    • Journal Title

      Organohalogen Compd. 64

      Pages: 316-319

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Species difference among mice, hamsters, rats and guinea pigs in 2,2',4',5,5'-pentachlorobiphenyl and 2,2',3',4',5,6-hexachlorobiphenyl-induced alterations of serum thyroid hormone level.2003

    • Author(s)
      Yoshihisa Kato
    • Journal Title

      Organohalogen Compd. 64

      Pages: 332-335

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Identification and tissue distribution of catechol metabolites of polychlorinated biphenyls in rodents dosed with Kanechlor 500.2003

    • Author(s)
      Koichi Haraguchi
    • Journal Title

      Organohalogen Compd. 64

      Pages: 345-348

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Metabolism of 2,3,3',4,4'-pentachlorobiphenyl in hamsters.2003

    • Author(s)
      Nobuyuki Koga
    • Journal Title

      Organohalogen Compd. 64

      Pages: 427-430

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Species difference among mice, hamsters, rats, and guinea pigs in Kanechlor-500-induced alteration of serum thyroid hormone level.2003

    • Author(s)
      Yoshihisa Kato
    • Journal Title

      J Toxicol. Sci. 28

      Pages: 321-321

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Species difference among mice, hamsters, rats, and guinea pigs in 2,2',4',5,5'-pentachlorobiphenyl or 2,2',3',4',5,6-hexachlorobiphenyl-induced alteration of serum thyroid hormone level.2003

    • Author(s)
      Yoshihisa Kato
    • Journal Title

      J. Toxicol. Sci. 28

      Pages: 322-322

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Book] 生体統御システムと内分泌撹乱、甲状腺ホルモン撹乱物質の生体作用の動物種差2005

    • Author(s)
      加藤善久
    • Total Pages
      7
    • Publisher
      シュプリンガー・フェアラーク東京
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Book] 甲状腺ホルモン撹乱物質の生体作用の動物種差.生体統御システムと内分泌撹乱2005

    • Author(s)
      加藤善久
    • Total Pages
      7
    • Publisher
      シュプリンガー・フェアラーク東京
    • Related Report
      2005 Annual Research Report
  • [Publications] Yoshihisa Kato: "Effects of polychlorinated biphenyls, Kanechlor-500, on serum thyroid hormone levels in rats and mice"Toxicol.Sci.. 72. 235-241 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] 古賀信幸: "2、3、3'、4、4'-五塩素化ビフェニル(CB105)のハムスターにおける代謝"福岡医学雑誌. 94. 174-182 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Yoshihisa Kato: "Species difference among mice, hamsters, rats and guinea pigs in Kanechlor-500-induced alterations of serum thyroid hormone level"Organohalogen Compd.. 64. 316-319 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Yoshihisa Kato: "Species difference among mice, hamsters, rats and guinea pigs in 2,2',4',5,5'-pentachlorobiphenyl and 2,2',3',4',5,6-hexachlorobiphenyl-induced alterations of serum thyroid hormone level"Organohalogen Compd.. 64. 332-335 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Yoshihisa Kato: "Species difference among mice, hamsters, rats, and guinea pigs in Kanechlor-500-induced alteration of serum thyroid hormone level"J.Toxicol.Sci.. 28. 321 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Yoshihisa Kato: "Species difference among mice, hamsters, rats, and guinea pigs in 2,2',4',5,5'-pentachlorobiphenyl or 2,2',3',4',5,6-hexachlorobiphenyl-induced alteration of serum thyroid hormone level"J.Toxicol.Sci.. 28. 322 (2003)

    • Related Report
      2003 Annual Research Report

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Published: 2003-04-01   Modified: 2016-04-21  

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