| Project/Area Number |
15510102
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Nanomaterials/Nanobioscience
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| Research Institution | Kobe University |
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Principal Investigator |
TAKEUCHI Toshifumi Kobe University, Graduate School of Science and Technology, Professor, 自然科学研究科, 教授 (70179612)
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| Project Period (FY) |
2003 – 2004
|
| Project Status |
Completed (Fiscal Year 2004)
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| Budget Amount *help |
¥3,800,000 (Direct Cost: ¥3,800,000)
Fiscal Year 2004: ¥800,000 (Direct Cost: ¥800,000)
Fiscal Year 2003: ¥3,000,000 (Direct Cost: ¥3,000,000)
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| Keywords | molecular imprinting / molecular recognition / シナジェティックシグナリング材料 |
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| Research Abstract |
Signaling-imprinted polymers were prepared for heterocyclic compounds using a polymerizable metalloporphyrin and/or methacrylic acid as functional monomer(s), and evaluated by chromatographic tests, Scatchard analysis, and spectroscopic analysis. In the polymers, the metalloporphyrin residue and methacrylic acid residues worked cooperatively at the imprinted binding site. A linear relationship was observed between the UV-Vis absorbance of the imprinted polymer and the logarithm of target concentrations, indicating that the polymer may be used as a selective sensing material for the given target molecule. Various metalloporphyrins can be used as functionalized monomers in order to prepare signaling-imprinted polymers for a wide range of target compounds capable of coordination with metalloporphyrins.
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