| Project/Area Number |
15510177
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Single-year Grants |
|---|
| Section | 一般 |
|---|
| Research Field |
Living organism molecular science
|
|---|
| Research Institution | The University of Tokushima |
|---|
Principal Investigator |
NEMOTO Hisao The University of Tokushima, Division of Health Biosciences, Associate Professor, 大学院・ヘルスバイオサイエンス研究部, 助教授 (30208293)
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
NIKAWA Takeshi The University of Tokushima, Division of Health Biosciences, Associate Professor, 大学院・ヘルスバイオサイエンス研究部, 助教授 (20263824)
SHIBUYA Masayuki The University of Tokushima, Vice President, 副学長 (40027066)
|
|---|
| Project Period (FY) |
2003 – 2004
|
| Project Status |
Completed (Fiscal Year 2004)
|
| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,900,000)
Fiscal Year 2004: ¥1,100,000 (Direct Cost: ¥1,100,000)
Fiscal Year 2003: ¥2,800,000 (Direct Cost: ¥2,800,000)
|
|---|
| Keywords | Masked Acyl Cyanide / peptide mimics / ubiquitin / umpolung / correspondence of an aging society / correspondence of the space age / inhibition effect of reducing musclar strength / MAC反応剤 / アシルアニオン等価体 |
|---|
| Research Abstract |
Development of compounds having inhibition effect of reducing muscular strength is one of the important propositions for various fields such as efficient rehabilitation in society for aged inpatients, or the maintenance of muscle of people engaging long-period spaceship activity. Nikawa, one of the investigators, discovered that several dipeptides inhibited the reduction of muscular strength. Nemoto, the head investigator, developed an efficient reagent, Masked Acyl Cyanide reagent (MAC reagent). MAC reagent enabled us to efficiently synthesize peptide mimics. The key reaction by MAC reagent proceeds in excellent chemical yield under mild conditions. We have succeeded the synthesis of five peptide mimics by using MAC reagent. Property of the five compounds are now examined by Nikawa. Nemoto also developed a novel synthetic route for the synthesis of MAC reagents via short steps without expensive reagents comparing with previously reported methods. By this new method, acylated MAC reagents were newly synthesized. MAC reagents will be soon commercially available by a reagent company. Nemoto developed new chemical reactions for the synthesis of alpha-acyloxy esters and alpha-amino esters by using the acylated MAC reagents.
|
