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Theoretical study on microdomains in biomembranes

Research Project

Project/Area Number 15540395
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Biophysics/Chemical physics
Research InstitutionTokyo Metropolitan University

Principal Investigator

KOMURA Shigeyuki  Tokyo Metropolitan University, Department of Chemistry, Associate Professor, 都市教養学部理工学系, 助教授 (90234715)

Project Period (FY) 2003 – 2005
Project Status Completed (Fiscal Year 2005)
Budget Amount *help
¥2,700,000 (Direct Cost: ¥2,700,000)
Fiscal Year 2005: ¥500,000 (Direct Cost: ¥500,000)
Fiscal Year 2004: ¥1,100,000 (Direct Cost: ¥1,100,000)
Fiscal Year 2003: ¥1,100,000 (Direct Cost: ¥1,100,000)
Keywordsmicrodomain / raft / lipid / cholesterol / soft matter / 生体膜 / 相分離 / ランダウ自由エネルギー
Research Abstract

In an effort to understand "rafts" in biological membranes, we propose phenomenological models for saturated and unsaturated lipid mixtures, and lipid plus cholesterol mixtures. We consider simple couplings between the local composition and internal membrane structure, and their influence on transitions between liquid and gel membrane phases. Assuming that the gel transition temperature of the saturated lipid is shifted by the presence of the unsaturated lipid, and that cholesterol acts as an external field on the chain melting transition, a variety of phase diagrams are obtained. Our results also apply to regions in the ternary phase diagram of lipid/lipid/cholesterol systems.
We propose models for the first-order unbinding transition of lyotropic lamellae in surfactant solutions. The coupling between the surfactant volume fraction and the elastic degree of freedom is considered so that the net attractive interaction between the surfactant molecules is enhanced. The elastic degree of freedom can be either (i) a membrane elastic degree of freedom, or (ii) a bulk elastic degree of freedom. The phase behaviors of these two models are analyzed. For the both cases, the unbinding transition becomes first-order when the coupling is strong enough. We determine the associated preunbinding line which separates two lamellar phases having different repeat distances.

Report

(4 results)
  • 2005 Annual Research Report   Final Research Report Summary
  • 2004 Annual Research Report
  • 2003 Annual Research Report
  • Research Products

    (27 results)

All 2006 2005 2004 2003 Other

All Journal Article (22 results) Publications (5 results)

  • [Journal Article] Unbinding and Preunbinding in Surfactant Solutions2006

    • Author(s)
      S.Komura, N.Shimokawa, T.Kato
    • Journal Title

      J. Chem. Phys. 124

      Pages: 34906-34906

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Unbinding and Preunbinding in Surfactant Solutions2006

    • Author(s)
      S.Komura, N.Shimokawa, T.Kato
    • Journal Title

      J.Chem.Phys. 124

      Pages: 34906-34906

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Phase Behavior of Three-Component Lipid Mixtures2005

    • Author(s)
      S.Komura, H.Shirotori, P.D.Olmsted
    • Journal Title

      J. Phys. : Condens. Matter 17

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Buckling of Spherical Shells Adhering onto a Rigid Substrate2005

    • Author(s)
      S.Komura, K.Tamura, T.Kato
    • Journal Title

      Eur. Phys. J. E 18

      Pages: 343-358

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Phase Behavior of Three-Component Lipid Mixtures2005

    • Author(s)
      S.Komura, H.Shirotori, P.D.Olmsted
    • Journal Title

      J.Phys. : Condens.Matter 17

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Annual Research Report 2005 Final Research Report Summary
  • [Journal Article] Buckling of Spherical Shells Adhering onto a Rigid Substrate2005

    • Author(s)
      S.Komura, K.Tamura, T.Kato
    • Journal Title

      Eur.Phys.J.E 18

      Pages: 343-358

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Annual Research Report 2005 Final Research Report Summary
  • [Journal Article] Shear-Induced Structural Transition in a Lyotropic Lamellar Phase Studied by Small-Angle Neutron and Light Scattering2005

    • Author(s)
      T.Kato, K.Miyazaki, Y.Kawabata, S.Komura, M.Fujii, M.Imai
    • Journal Title

      J.Phys. : Condens.Matter 17

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Surfactant Mesophases Mediated by Colloidal Particles2005

    • Author(s)
      M.Imai, Y.Suganuma, K.Nakaya, S.Komura
    • Journal Title

      J.Phys. : Condens.Matter 17

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Polymer-Confinement-Induced Nematic Transition of Microemulsion Droplets2005

    • Author(s)
      K.Nakaya, M.Imai, S.Komura, T.Kawakatsu, N.Urakami
    • Journal Title

      Europhys.Lett. 71

      Pages: 494-500

    • NAID

      130004589455

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Unbinding and Preunbinding in Surfactant Solutions2005

    • Author(s)
      S.Komura, N.Shimokawa, T.Kato
    • Journal Title

      J.Chem.Phys. 124

      Pages: 34906-34906

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Phase behavior of three-component lipid mixtures2005

    • Author(s)
      S.Komura, H.Shirotori, P.D.Olmsted
    • Journal Title

      J.Phys.: Condens. Matter

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Lateral Phase Separation in Mixtures of Lipids and Cholesterol Systems2004

    • Author(s)
      S.Komura, H.Shirotori, P.D.Olmsted, D.Andelman
    • Journal Title

      Europhys. Lett. 67

      Pages: 321-327

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Lateral Phase Separation in Mixtures of Lipids and Cholesterol Systems2004

    • Author(s)
      S.Komura, H.Shirotori, P.D.Olmsted, D.Andelman
    • Journal Title

      Europhys.Lett. 67

      Pages: 321-327

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Lateral Phase Separation in Mixtures of Lipids and Chole sterol Systems2004

    • Author(s)
      S.Komura, H.Shirotori, P.D.Olmsted, D.Andelman
    • Journal Title

      Europhys.Lett. 67

      Pages: 321-327

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Adhesion Induced Buckling of Spherical Shells2004

    • Author(s)
      K.Tamura, S.Komura, T.Kato
    • Journal Title

      J.Phys.Condens.Matter 16

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Effects of Shear Flow on Structures of Lamellar Phase in a Nonionic Surfactant/Water System2004

    • Author(s)
      T.Kato, K.Minewaki, K.Miyazaki, Y.Kawabata, T.Shikata, S.Komura, M.Fujii
    • Journal Title

      Prog.Colloid Polym.Sci. 129

      Pages: 9-15

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Adsorption of Rod-Shaped Surface-Active Particles at Liquid-Liquid Interfaces2004

    • Author(s)
      Y.Nonomura, S.Komura, K.Tsujii
    • Journal Title

      J.Oleo Sci. 53

      Pages: 607-610

    • NAID

      130000060744

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Adsorption of Disk-Shaped Janus Beads at Liquid-Liquid Interfaces2004

    • Author(s)
      Y.Nonomura, S.Komura, K.Tsujii
    • Journal Title

      Langmuir 20

      Pages: 11821-11823

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Phase Behavior of Charged Lipid Bilayer Membranes with Added Electrolyte2003

    • Author(s)
      S.Komura, H.Shirotori, T.Kato
    • Journal Title

      J. Chem. Phys 119

      Pages: 1157-1164

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] The Unbinding Transition of Mixed Fluid Membranes2003

    • Author(s)
      S.Komura, D.Andelman
    • Journal Title

      Europhys. Lett. 64

      Pages: 844-850

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Phase Behavior of Charged Lipid Bilayer Membranes with Added Electrolyte2003

    • Author(s)
      S.Komura, H.Shirotori, T.Kato
    • Journal Title

      J.Chem.Phys. 119

      Pages: 1157-1164

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] The Unbinding Transition of Mixed Fluid Membranes2003

    • Author(s)
      S.Komura, D.Andelman
    • Journal Title

      Europhys.Lett. 64

      Pages: 844-850

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Publications] S.Komura, H.Shirotori, T.Kato: "Phase behavior of charged lipid bilayer membranes with added electrolyte"J.Chem.Phys.. 119. 1157-1164 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] S.Komura, D.Andelman: "The unbinding transition of mixed fluid membranes"Europhys.Lett.. 64. 844-850 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Y.Nonomura, K.Fukuda, S.Komura, K.Tsuji: "Self-assembly of surface active powder at the interfaces of selective liquids"Langmuir. 19. 10152-1015* (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Y.Kawahata et al.: "Temperature and pressure effect on the bending modulus of monolayers in a fernary microemulsion"Phys.Rev Lett. 92. 056103 (2004)

    • Related Report
      2003 Annual Research Report
  • [Publications] S.Komura, K.Tamura, T.Kato: "Deformation of adhering elastic tubes"Eur.Phys.J.E. 13. 73-77 (2004)

    • Related Report
      2003 Annual Research Report

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Published: 2003-04-01   Modified: 2016-04-21  

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