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Control of association and gelation behavior of ABA triblock copolymers by means of conformational transition of B block

Research Project

Project/Area Number 15550105
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Polymer chemistry
Research InstitutionNagoya Institute of Technology

Principal Investigator

INOMATA Katsuhiro  Nagoya Institute of Technology, Graduate School of Engineering, Associate professor, 大学院・工学研究科, 助教授 (80232578)

Project Period (FY) 2003 – 2005
Project Status Completed (Fiscal Year 2005)
Budget Amount *help
¥3,600,000 (Direct Cost: ¥3,600,000)
Fiscal Year 2005: ¥1,100,000 (Direct Cost: ¥1,100,000)
Fiscal Year 2004: ¥1,100,000 (Direct Cost: ¥1,100,000)
Fiscal Year 2003: ¥1,400,000 (Direct Cost: ¥1,400,000)
Keywordswater-soluble polypeptides / association behavior / gelation / helix-coil transition / light scattering / block copolymer / amphiphilic polymers / 架橋構造 / トリブロック共重合体 / ネットワーク構造 / アミノリシス反応
Research Abstract

Both-ends hydrophobically-modified water-soluble polypeptide, in which hydrophobic n-dodecyl (C12) groups are bonded at the both chain ends of poly[N^5-(2-hydroxyethyl) L-glutamine] (PHEG), has been prepared. Helix-coil transition and association behavior of this associative polypeptide in water/ethylene glycol (EG) mixed solvent, which is selective for PHEG block, have been investigated.
1.In dilute aqueous solution, the middle PHEG chain is in random coil state, and isolated small-size micelles were formed by association of hydrophobic C12 groups. The micellar size increased drastically with the increase of EG content in the mixed solvent. These results suggest that the increase of the helix content of PHEG induces the increase of fraction of bridge conformation connecting different C12 associated cores, which results in the change of structure from an isolated associate to a large associate including multiple associated cores connected by PHEG chains.
2.The above association scheme can explain process dependencies of sample preparation on the association in dilute solutions as well as gelation behavior of semi-concentrated solutions.
3.Association behavior of one-end hydrophobically-modified PHEGs was also investigated. Association strength was increased with the increase of hydrophobicity of the terminal alkyl chain. Conformational transition of PHEG chain induced a change in micellar structure, i.e., spherical shape when PHEG is in random coil state and worm-like cylinder when PHEG in α-helix conformation.
4.Block copolymer of PHEG and poly(ethylene glycol) was prepared, and its association in a selective solvent for poly(ethylene glycol) was investigated. When PHEG is in α-helical state, the associate is in hollow cylindrical shape because of a packing of rigid PHEG chain. When PHEG prefer to take random-coil conformation, formation of a normal core-corona type wormlike cylinder was suggested.

Report

(4 results)
  • 2005 Annual Research Report   Final Research Report Summary
  • 2004 Annual Research Report
  • 2003 Annual Research Report
  • Research Products

    (16 results)

All 2005 2003 Other

All Journal Article (13 results) Publications (3 results)

  • [Journal Article] Side-chain Crystallization Behavior of Graft Copolymers Consisting of Amorphous Main Chain and Crystalline Side Chains : Poly(methylacrylarte)-graft-poly(ethylene glycol) and Poly(methylacrylarte)-graft-poly(ethylene glycol)2005

    • Author(s)
      Katsuhiro Inomata
    • Journal Title

      J. Polym. Sci., Part B, Polym. Phys. 43(1)

      Pages: 79-86

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Helix-Coil Transition and Micellar Structure of Poly(ethylene glycol)-block-poly[N5-(2-hydroxyethyl) L-glutamine] in Cyclohexanol/Water Mixed Solvents2005

    • Author(s)
      Katsuhiro Inomata
    • Journal Title

      Polym. J. 37(6)

      Pages: 404-412

    • NAID

      10016148309

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Effect of helix-coil transition on association behavior of both-ends hydrophobically-modified water-soluble polypeptide2005

    • Author(s)
      Katsuhiro Inomata
    • Journal Title

      Polymer 46

      Pages: 10035-10044

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Annual Research Report 2005 Final Research Report Summary
  • [Journal Article] Side-chain Crystallization Behavior of Graft Copolymers Consisting of Amorphous Main Chain and Crystalline Side Chains : Poly(methyl methacrylate)-graft-poly(ethylene glycol) and Poly(methyl acrylarte)-graft-poly(ethylene glycol)2005

    • Author(s)
      Katsuhiro Inomata
    • Journal Title

      J.Polym.Sci., Part B, Polym.Phys. 43(1)

      Pages: 79-86

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Structural Study on Rodlike Aromatic Polyimides Derived by Solid-state Thermal and Chemical Imidization of Poly(amic n-dodecyl ester)2005

    • Author(s)
      Katsuhiro Inomata
    • Journal Title

      J.Mol.Struct. 739

      Pages: 117-123

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Helix-Coil Transition and Micellar Structure of Poly(ethylene glycol)-block-poly[N^5-(2-hydroxyethyl) L-glutamine] in Cyclohexanol/Water Mixed Solvents2005

    • Author(s)
      Katsuhiro Inomata
    • Journal Title

      Polym.J. 37(6)

      Pages: 404-412

    • NAID

      10016148309

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Structural Study on Rodlike Aromatic Polyimides Derived by Solid-state Thermal and Chemical Imidization of Poly(amic n-dodecyl ester)2005

    • Author(s)
      Katsuhiro Inomata
    • Journal Title

      Journal of Molecular Structure 739

      Pages: 117-123

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Helix-Coil Transition and Micellar Structure of Poly(ethylene glycol)-block-poly[N^5-(2-hydroxyethyl) L-glutamine] in Cyclohexanol/Water Mixed Solvents2005

    • Author(s)
      Katsuhiro Inomata
    • Journal Title

      Polymer Journal 37(6)

      Pages: 404-412

    • NAID

      10016148309

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Side-chain Crystallization Behavior of Graft Copolymers Consisting of Amorphous Main Chain and Crystalline Side Chains2005

    • Author(s)
      Katsuhiro Inomata
    • Journal Title

      Journal of Polymer Science, Part B, Polymer Physics 43・1

      Pages: 79-86

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Structural Study on Rodlike Aromatic Polyimides Derived by Solid-state Thermal and Chemical Imidization of Poly(amic n-dodecyl ester)2005

    • Author(s)
      Katsuhiro Inomata
    • Journal Title

      Journal of Molecular Structure in press

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Helix-Coil Transition and Micellar Structure of Poly(ethylene glycol)-block-poly[N^5-(2-hydroxyethyl) L-glutamine] in Cyclohexanol/Water Mixed Solvents2005

    • Author(s)
      Katsuhiro Inomata
    • Journal Title

      Polymer Journal in press

    • NAID

      10016148309

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Association and physical gelation of ABA triblock copolymer in selective solvent2003

    • Author(s)
      Katsuhiro Inomata
    • Journal Title

      Polymer 44(18)

      Pages: 5303-5310

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Association and physical gelation of ABA triblock copolymer in selective solvent2003

    • Author(s)
      Katsuhiro Inomata
    • Journal Title

      Polymer 44・18

      Pages: 5303-5310

    • Related Report
      2004 Annual Research Report
  • [Publications] Katsuhiro Inomata: "Association and physical gelation of ABA triblock copolymer in selective solvent"Polymer. 44・18. 5303-5310 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] 猪股克弘: "非晶性主鎖と結晶性側鎖からなるグラフト共重合体の相挙動と高次構造"高分子加工. 53・3. 134-139 (2004)

    • Related Report
      2003 Annual Research Report
  • [Publications] Akinori Takasu: "Threo-Disyndiotactic Polymerization of (E,E)-Alkyl Sorbates Catalyzed by Bulky Organo-aluminum Lewis Acid via "Alternating Turning Over Polymerization (ATOP)" Mechanism"Macromolecules. 36・19. 7055-7064 (2003)

    • Related Report
      2003 Annual Research Report

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Published: 2003-04-01   Modified: 2016-04-21  

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