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Development of a quick in -vivo sensing system based on fiber-optics for cancer diagnostics at very early stage

Research Project

Project/Area Number 15560362
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Measurement engineering
Research InstitutionHokkaido Institute of Technology

Principal Investigator

SASAKI Issei  Faculty of Engineering, Department of Information Network Engineering, Professor, 工学部, 教授 (00002006)

Co-Investigator(Kenkyū-buntansha) 数坂 昭夫  北海道大学, 大学院・獣医学研究科, 助教授 (00002113)
Project Period (FY) 2003 – 2004
Project Status Completed (Fiscal Year 2004)
Budget Amount *help
¥3,700,000 (Direct Cost: ¥3,700,000)
Fiscal Year 2004: ¥700,000 (Direct Cost: ¥700,000)
Fiscal Year 2003: ¥3,000,000 (Direct Cost: ¥3,000,000)
Keywordsoptical fiber sensor / optical-bio-sensor / cancer diagnositcs / cytochrome P450 / cancer initiation enzyme / P450 / EROD / cytochrome P450 / ethoxyresorufin
Research Abstract

It is well know that at the initial stage of cancer development, some particular types of enzyme such as cytochrome P450 1A often act an important role with carcinogens to produce DNA-carcinogen adducts, as initiation of cancer development. In fact, it is understood that the induction itself of such type of enzymes maybe a remarkable indication of higher cancer risk condition. We have thus proposed anew method of cancer diagnostics based on the information of enzyme activities. It maybe invaluable on medical point of the view if cancer diagnostics can be done at very early stage before arising cancer cells.
In the research term of 2003 -2004 of the grant, we have paid our efforts to the development of a fiber-optic sensing system in order to realize the new method of cancer diagnostics. As the result of the work, a quick (short consumption time for diagnostic treatment), in-vivo (directly applicable to human skim) system has been successfully completed. The system uses fluorescent species caused by the enzyme reaction to detect the object enzyme activities by means of optical technique using a pair of optical fibers; one is for delivering excitation light source and the other for guiding signal light to a highly sensitive photo-detector. The higher activity of the enzymes reveals the steeper slope in the curve of luminescent power increase and thus it can be evaluate from the behavior of the fluorescent power at the fiber sensor output.
Because of its smallness in diameter and flexibility, a plastic optical fiber was employed as the fiber sensor and thus it allows us to access to anywhere in a body. We found, however, that optimum condition in the space between sensor head and the object to be tested exists at Immseparation.
In conclusions, non-contact operation of the new cancer diagnostic method is now technically possible and we have a plan to continue the research for practical use of the fiber optic sensor system to real medial cancer diagnostics.

Report

(3 results)
  • 2004 Annual Research Report   Final Research Report Summary
  • 2003 Annual Research Report
  • Research Products

    (17 results)

All 2004 2003 2002 Other

All Journal Article (11 results) Publications (6 results)

  • [Journal Article] PPARalpha-dependent modulation of hepatic CYP1A by clofibric acid in rats2004

    • Author(s)
      Z.Shaban, A.Kazusaka, et al.
    • Journal Title

      Arch.Toxicol. 78(9)

      Pages: 496-507

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Development of Fiber Optic Sensing System for Analyzing Isozymes Reaction of Cytochrome P450-1A Doubted as Carcinogen Activator2003

    • Author(s)
      I.Yamakawa, I.Sasaki, et al.
    • Journal Title

      Optical Review 10(6)

      Pages: 585-587

    • NAID

      10011841816

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] High-Performance Fiber-Optic Sensing System Developed for Medieal Assessment of Cytochrome P450 Activity2003

    • Author(s)
      I.Yamakawa, I.Sasaki, et al.
    • Journal Title

      Technical Digest 16^<th> International Coference on Optical Fiber Sensors ThP-8

      Pages: 598-601

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Development of Fiber Optic Sensing System for Analyzing Isozymes Reaction of Cytochrome P450-IA Doubted as Carcinogen Activator2003

    • Author(s)
      I.Yamakawa, I.Sasaki et al.
    • Journal Title

      Optical Review 10(5)

      Pages: 585-587

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] High-Performance Fiber-Optic Sensing System Developed for Medical Assessment of Cytochrome P450 Activity2003

    • Author(s)
      I.Yamakawa, I.Sasaki et al.
    • Journal Title

      Technical Digest 16^<th> International Coference on Optical Fiber Sensors ThP-8

      Pages: 598-601

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Short period exposure to di-(2-ethylhexyl)phthalate regulates testosterone metabolism in testis of prepubertal rats2003

    • Author(s)
      K.Q.akamoto, A.Kazusaka, et al.
    • Journal Title

      Arch.Toxicol. 77(8)

      Pages: 446-451

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Development of fiber optic sensing system for analyzing isozymes reaction of cytochrome P450-1A doubted as carcinogen activator2003

    • Author(s)
      I.Yamakawa, I.Sasaki et al.
    • Journal Title

      Optical Review 10(6)

      Pages: 585-587

    • NAID

      10011841816

    • Related Report
      2004 Annual Research Report
  • [Journal Article] High-performance fiber-optic sensing system developed for medical assessment of cytochrome P450 activity2003

    • Author(s)
      I.Yamakawa, I.Sasaki et al.
    • Journal Title

      Technical Digest 16^<th> International Conference on Optical Fiber Sensors ThP-8

      Pages: 598-601

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Fiber Optic Sensing Technique for Evaluating the Activity of Cytochrome P450 Douted as Carcinogen Activator2002

    • Author(s)
      I.Yamakawa, I.Sasaki, et al.
    • Journal Title

      Proceedings of Asian Symposium on Biomedical Optics and Photomedicine WB1-3

      Pages: 224-225

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Fiber Optic Sensing Technique for Evaluating the Activity of Cytochrome P450 Douted as Carcinogen Activator2002

    • Author(s)
      I.Yamakawa, I.Sasaki et al.
    • Journal Title

      Proceedings of Asian Symposium on Biomedical Optics and Photomedicine WB1-3

      Pages: 224-225

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Fiber optic sensing technique for evaluating the activity of cytochrome P450 douted as carcinogen activator2002

    • Author(s)
      I.Yamakawa, I.Sasaki et al.
    • Journal Title

      Proceedings of Asian Symposium on Biomedical Optics and Photomedicine WB1-3

      Pages: 224-225

    • Related Report
      2004 Annual Research Report
  • [Publications] I.Yamakawa, Y.Saitoh, A.Usui, A.Kazusaka, I.Sasaki: "High-performance fiber-optic sensing system developed for medical assessment of cytochrome P450 activity"Measurement Science and Technology. (採録決定). (2004)

    • Related Report
      2003 Annual Research Report
  • [Publications] I.Yamakawa, Y.Saitoh, A.Usui, A.Kazusaka, I.Sasaki: "High-Performance Fiber-Optic Sensing System Developed for Medical Assessment of Cytochrome P450 Activity"Proceedings of 16^<th> International Conference on Optical Fiber Sesor (OFS-16). ThP-8. 596-601 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] I.Yamakawa, Y.Saitoh, A.Usui, A.Kazusaka, I.Sasaki: "Development of Fiber Optic Sensing System for Analyzing Isozymes Reaction of Cytochrome P450-1A Doubted as Carcinogen Activator"OPTICAL REVIEW. Vol.10 No.6. 585-587 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] 臼井, 斉藤, 山川, 数坂, 佐々木: "光ファイババイオセンシング技術に基づく食品の安全性評価システムの開発"第8回電子情報通信学会北海道支部インターネットシンポジウム論文集. 40-44 (2004)

    • Related Report
      2003 Annual Research Report
  • [Publications] 山川, 臼井, 斉藤, 数坂, 佐々木: "光ファイバセンシングシステムによる代謝酵素Cytochrome-P450の検出および定量法の検討"第8回電子情報通信学会北海道支部インターネットシンポジウム論文集. 48-51 (2004)

    • Related Report
      2003 Annual Research Report
  • [Publications] 斉藤, 臼井, 山川, 数坂, 佐々木: "光ファイバ-バイオセンシングシステムを用いた環境汚染評価法の検討"第8回電子情報通信学会北海道支部インターネットシンポジウム論文集. 27-30 (2004)

    • Related Report
      2003 Annual Research Report

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Published: 2003-04-01   Modified: 2016-04-21  

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