• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Neurobiology of hydra primitive nervous system

Research Project

Project/Area Number 15570070
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Animal physiology/Animal behavior
Research InstitutionFukuoka Women's University

Principal Investigator

KOIZUMI Osamu  Fukuoka Women's University, Environmental Science, 人間環境学部, 教授 (50094777)

Co-Investigator(Kenkyū-buntansha) MINOBE Sumiko  Fukuoka Women's University, Environmental Science, 人間環境学部, 助手 (80190718)
Project Period (FY) 2003 – 2004
Project Status Completed (Fiscal Year 2004)
Budget Amount *help
¥3,700,000 (Direct Cost: ¥3,700,000)
Fiscal Year 2004: ¥1,700,000 (Direct Cost: ¥1,700,000)
Fiscal Year 2003: ¥2,000,000 (Direct Cost: ¥2,000,000)
Keywordsdiffuse nervous system / hydra / nerve net formation / developmental neurobiology / peptide / immunihistochemis / antibody production / nerve differentiation / 神経生理学
Research Abstract

(1)Structure of the diffuse nervous system of hydra (neuroanatomy)
Large scale screening of peptide signal molecules in hydra, many novel peptides were identified We produced antibodies against every peptides. Using these antibodies, we did chemical anatomy of hydra nervous system.
(2)Function of the diffuse nervous system of hydra (neurophysiology, behaviorall physidogy)
We demonstrated that the simple nervous system of hydra had abilities comparable to central nervous system of the higher animals. We examined our hypothesis nerve ring in hydra is the originn of the central nervous system of higher nervous system We identified a function of the nerve ring, which was the coordination of the simulutanous tentacle movement, crumpling..
(3)Formation of the diffuse nmous system of hydra (developmental neurobiology)
We identified two types of peptides, one is Hym355 activating nerve differentiation of hydra, and the other is LPW peptide family inhibiting nerve differentiation of hydra. Hym355 was a neuropeptide, but LPW family was epitheliopeptides. These peptides were demonstrated to affect on the nerve stem cells, interstitial celsl.

Report

(3 results)
  • 2004 Annual Research Report   Final Research Report Summary
  • 2003 Annual Research Report
  • Research Products

    (21 results)

All 2005 2004 2003 2002 2001 Other

All Journal Article (16 results) Publications (5 results)

  • [Journal Article] Production of antibody specific to each member in RFamide family, and its application.2005

    • Author(s)
      Koizumi, O., Noda, M., Kato M.
    • Journal Title

      Peptide Science 2004 (in Press)

    • NAID

      10014460027

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Chemical anatomy of hydra nervous system using antibodies against hydra neuropeptides : a review.2004

    • Author(s)
      Osamu Koizumi
    • Journal Title

      Coelenterate Biology 2003 : Trends in research on Cnidaria and Ctenophore (Kluwer)

      Pages: 41-47

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Three digestive movements in Hydra regulated by the diffuse nerve net in the body column.2004

    • Author(s)
      S.Shimizu
    • Journal Title

      J.Comp.Physiol.A 190

      Pages: 623-630

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Annual Research Report 2004 Final Research Report Summary
  • [Journal Article] Chemical anatomy of hydra nervous system using antibodies against hydra neuropeptides : a review.2004

    • Author(s)
      Koizumi, O., Sato, N., Goto, C.
    • Journal Title

      Coelenterate Biology 2003 : Trends in research on Cnidaria and Ctenophora (Kluwer)

      Pages: 41-47

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Three digestive movements in Hydra regulated by the diffuse nerve net in the body column.2004

    • Author(s)
      Shimizu, H., Koizumi O., Fujisawa, T.
    • Journal Title

      J.Comp.Physiol.A 190

      Pages: 623-630

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Chmemical anatomy of hydra nervous system using antibodies against hydra neuropeptides : a review.2004

    • Author(s)
      Osamu Koizumi
    • Journal Title

      Coelenterate Biology 2003 : Trends in research on Cnidaria and Ctenonhora (Kluwer)

      Pages: 41-47

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Biochemical evaluation of hormonal activity of endocrine disruptors by sensing the estrogen receptor conformation changes2003

    • Author(s)
      D.Asai
    • Journal Title

      Peptide Science 2002

      Pages: 127-130

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Annual Research Report 2004 Final Research Report Summary
  • [Journal Article] Identification of a vasopressin-like immunoreactive substance in hydra.2003

    • Author(s)
      Morishita, F
    • Journal Title

      Peptides 24

      Pages: 17-26

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Annual Research Report 2004 Final Research Report Summary
  • [Journal Article] Identification of a new member of the GLWamide peptide family : physiological activity and cellular localization in cnidarian polyps.2003

    • Author(s)
      Takahashi, T.
    • Journal Title

      Comp.Biochem.Physiol.(B) 135

      Pages: 309-324

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Annual Research Report 2004 Final Research Report Summary
  • [Journal Article] Developmental neurobiology of hydra, a model animal of cnidarians2003

    • Author(s)
      Koizumi, O.
    • Journal Title

      Can.J.Zool. 80

      Pages: 178-1689

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Annual Research Report 2004 Final Research Report Summary
  • [Journal Article] Biochemical evaluation of hormonal activity of endocrine disruptors by sensing the estrogen receptor conformation changes.2003

    • Author(s)
      Asai, D., Koizumi, O., Mohri.S., Nakai, M., Yakabe, Y., Tokunaga, T, Nose, T., Shimohigashi, Y.
    • Journal Title

      Peptide Science 2002

      Pages: 127-130

    • NAID

      80015974537

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Identification of a vasopressin-like immunoreactive substance in hydra.2003

    • Author(s)
      Morishita, F., Nitagai, Y., Furukawa, Y., Matsushima, O., Takahashi, T., Hatta, M., Fujisawa, T., Tunamoto, T., Koizumi, O.
    • Journal Title

      Peptides 24

      Pages: 17-26

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Identification of a new member of the GLWamide peptide family : physiological activity and cellular localization in cnidarian polyps.2003

    • Author(s)
      Takahashi, T., Kobayakawa, Y., Muneoka, Y., Fujisawa, Y., Mohri, S., Hatta, M., Shimizu, H., Fujisawa, T., Sugiyama, T., Takahara, M., Yanagi, K., Koizumi, O.
    • Journal Title

      Comp.Biochem.Physiol.(B) 135

      Pages: 309-324

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Developmental neurobiology of hydra, a model animal of cnidarians.2002

    • Author(s)
      Koizumi, O.
    • Journal Title

      Can.J.Zool. 80

      Pages: 1678-1689

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Preparation of the antibody which discriminates the conformations of ligand-bound and ligand-free estrogen receptors : Applications to the quantitative analysis of ligand bindings.2001

    • Author(s)
      Asai, D., Koizumi, O., Shirou Mohri, Shimohigashi, Y.
    • Journal Title

      Peptide Science, 2000

      Pages: 411-412

    • NAID

      10009957726

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Nuclear receptor binding assay by sensing changes in receptor conformation.2001

    • Author(s)
      Shimohigashi, Y., Asai, D., Yakabe, Y., Takatsuki, M., Nose, T., Sagkaguchi, K., Mohri, S., Koizumi, O.
    • Journal Title

      Environ.Sci. 8

      Pages: 3-4

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Publications] S.Shimizu: "The diffuse nerve net in Hydra body column represents a primitive enteric nervous system."J.comp.physiol.. in Press. (2004)

    • Related Report
      2003 Annual Research Report
  • [Publications] O.Koizumi: "Chemical anatomy of hydra nervous system using antibodies against hydra neuropeptides : a review."Hydrobiologia. in Press. (2004)

    • Related Report
      2003 Annual Research Report
  • [Publications] Asai, D.: "Biochemical evaluation of hormonal activity of endocrine disruptors by sensing the estrogen receptor conformation changes."Peptide Science. 2002. 127-130 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Morishita, F.: "Identification of a vasopressin-like immunoreactive substance in hydra."Peptides. 24. 17-26 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Takahashi, T.: "Identification of a new member of the GLWamide peptide family : physiological activity and cellular localization in cnidarian polyps."Comp.Biochem.Physiol.(B). 135. 309-324 (2003)

    • Related Report
      2003 Annual Research Report

URL: 

Published: 2003-04-01   Modified: 2016-04-21  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi