| Project/Area Number |
15580104
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Food science
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| Research Institution | Nagoya University |
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Principal Investigator |
ODA Hiroaki Nagoya University, Graduate School of Bioagricultural Science, Associate Professor (20204208)
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| Project Period (FY) |
2003 – 2004
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| Project Status |
Completed (Fiscal Year 2006)
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| Budget Amount *help |
¥3,800,000 (Direct Cost: ¥3,800,000)
Fiscal Year 2004: ¥1,100,000 (Direct Cost: ¥1,100,000)
Fiscal Year 2003: ¥2,700,000 (Direct Cost: ¥2,700,000)
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| Keywords | lipid metabolism / cholesterol / sulfur-containing amino acids / relative availability of SAA / 生活習慣病 / 高脂血症 / タンパク質 / アミノ酸 / アミノ酸の脂質代謝改善指数 / 肥満 |
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| Research Abstract |
Abnormality of lipid metabolism is known to be associated with lifestyle-related diseases such as metabolic syndrome. It is necessary to normalize cholesterol metabolism in blood for prevention. and treatment of atherosclerosis. It is known that plasma lipid levels are controlled not only by dietary fat and carbohydrate but also by dietary protein and amino acids. Although it used to be thought that the source of protein was important, it is known that amino acid composition, amino acids themselves, and peptides from digested protein are more important than the protein source. Sulfur-containing amino acids (SAAs) are recognized to be some of the most potent modulators of lipid metabolism among amino acids. It has been demonstrated that SAAs have an increasing effect on HDL (high-density lipoprotein)-cholesteml and a decreasing effect on VLDL (very low-density lipoprotein)-cholesterol. These data lead usto propose that SAAs have some beneficial functions against atherosclerotic diseases and metabolic syndrome. Relative availability of SAAs (RASAA) as well as the amount of SAAs in dietary protein would determine lipid metabolism. Therefore, we propose RASAA as a feasible index for improvement of lipid metabolism by amino acids. Although it is not clear how SAAs influence gene expression and lipid metabolism at a molecular level, SAAs change the metabolic pathway through transcriptional stimulation and posttranslational modification ofregulatory proteins.
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