| Project/Area Number |
15590013
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Chemical pharmacy
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| Research Institution | Kumamoto University |
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Principal Investigator |
ISHIZUKA Tadao Kumamoto University, faculty of medical and pharmaceutical Sciences, Associate Professor, 大学院・医学薬学研究部, 助教授 (60176203)
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| Project Period (FY) |
2003 – 2005
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| Project Status |
Completed (Fiscal Year 2005)
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| Budget Amount *help |
¥3,500,000 (Direct Cost: ¥3,500,000)
Fiscal Year 2005: ¥700,000 (Direct Cost: ¥700,000)
Fiscal Year 2004: ¥1,400,000 (Direct Cost: ¥1,400,000)
Fiscal Year 2003: ¥1,400,000 (Direct Cost: ¥1,400,000)
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| Keywords | Moleculary Imprinting / Asymmetric synthesis / Polymer / Diamine / Amino alcohol / 不斉合成 / 不斉触媒 |
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| Research Abstract |
Molecularly imprinted polymers were synthesized by use of bicyclic chiral aminoalcohols as template. The difference of affinities between the template molecule and other aminoalcohols to the polymers were detected by HPLC analysis, selective adsorbtion of templete molecule were observed. Moreover, the templete aminoalcohols showed priority in adosorbtion to the imprinted polymer over its enantiomer.
Asymmetric reactions with template molecules as catalysts were examined. Sulfonamides, thiazolines and thioethers with bicyclic skeleton were successfully utilized in hydrogen-transfer reduction of ketones, the Diels-Alder reactions and π-allyl alkylations, respectively. These compounds showed not only high yields and excellent selectiveties but marvelous character that cannot be affected by sterically bulkyness of substrate.
These catalysts might be good templetes of imprinted polymers because of these basic characters and restricted conformations. Further investigations will be needed for application of the imprinted polymers to these asymmetric reactions.
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