• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Elucidation of gene expression mechanisms of kidney-specific organic cation transporter OCT2 by promoter analyses.

Research Project

Project/Area Number 15590128
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Medical pharmacy
Research InstitutionMie University (2004)
Kyoto University (2003)

Principal Investigator

OKUDA Masahiro  Mie University, Mie University Hospital, Professor, 医学部附属病院, 教授 (70252426)

Co-Investigator(Kenkyū-buntansha) MASUDA Satohiro  Kyoto University, Graduate School of Medicine, Lecturer, 医学研究科, 講師 (90303825)
Project Period (FY) 2003 – 2004
Project Status Completed (Fiscal Year 2004)
Budget Amount *help
¥3,600,000 (Direct Cost: ¥3,600,000)
Fiscal Year 2004: ¥1,400,000 (Direct Cost: ¥1,400,000)
Fiscal Year 2003: ¥2,200,000 (Direct Cost: ¥2,200,000)
KeywordsOrganic Cation Transporter / Renal Tubules / OCT2 / Promoter / Sex-related differences / Testosterone / Transcriptional regulation / Basic drugs
Research Abstract

Using rat kidney cDNA library, 5'-temnial region of rOCT2 gene was amplified by 5'-RACE method. We found that the transcription initiation site of rOCT2 was located at 306 bases above translation initiation site. Next, we tried to isolate rOCT2 promoter region by screening rat genomic library using cDNA probes corresponding to 3.0 kb upstream region of the translation initiation site. A cDNA about 3 kb long was isolated and harbored into pGL3 vector, and then transfected into LLC-PK_1 cells. Measurement of promoter activity revealed that the transcription was enhanced in the presence of testosterone. Furthermore, saturation of promoter activity was observed with 10 nM or higher concentrations of testosterone, which was equivalent to the physiological concentration of testosterone in male rat.
In the promoter region of rOCT2, five portions of base sequences were found to be similar to androgen receptor response elements, ARE, which could play a relevant role in the regulation of rOCT2 transcription. Therefore, we generated constracts containing truncated products of rOCT2 promoter, and then introduced into LLC-PK_1 cells together with rat androgen receptor. The results of promoter assay revealed that nucleic acid sequences between positions -3,036 and -819 were involved in the regulation of rOCT2 transcription. Furthermore, mutations were introduced into five AREs, and then subjected to promoter assay. As the results, two AREs around positions -3,000 and -1,200 were suggested to be involved in the regulation of rOCT2 transcription.
This is the first evidence demonstrating that the organic cation transporter 2 are regulated at the level of transcription, and considered to be useful for understanding gender differences in the renal elimination activity of cationic drugs.

Report

(3 results)
  • 2004 Annual Research Report   Final Research Report Summary
  • 2003 Annual Research Report
  • Research Products

    (75 results)

All 2005 2004 2003 Other

All Journal Article (60 results) Book (1 results) Publications (14 results)

  • [Journal Article] Distinct inhibitory effects of tacrolimus and cyclosporin a on calcineurin phosphatase activity.2005

    • Author(s)
      Fukudo, M.
    • Journal Title

      J.Pharmacol.Exp.Ther. 312

      Pages: 816-825

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Restored expression and activity of organic ion transporters rOAT1, rOAT3 and rOCT2 after hyperuricemia in the rat kidney.2005

    • Author(s)
      Habu, Y.
    • Journal Title

      Blochem.Pharmacol. 69

      Pages: 993-999

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Altered pharmacokinetics of paclitaxel in experimental hepatic or renal failure.2005

    • Author(s)
      Jiko, M.
    • Journal Title

      Pharm.Res. 22

      Pages: 228-234

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Metformin transport by renal basolateral organic cation transporter hOCT2.2005

    • Author(s)
      Kimura, N.
    • Journal Title

      Pharm.Res. 2005

      Pages: 255-259

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Transient up-regulation of P-glycoprotein reduces tacrolimus absorption after ischemia-reperfusion injury in rat ileum.2005

    • Author(s)
      Omae, T.
    • Journal Title

      Blochem.Pharmacol. 69

      Pages: 561-568

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Distinct inhibitory effects of tacrolimus and cyclosporin a on calcineurin phosphatase activity.2005

    • Author(s)
      Fukudo, M. et al.
    • Journal Title

      J.Pharmacol.Exp.Ther. 312-2

      Pages: 816-825

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Restored expression and activity of organic ion transporters rOAT1,rOAT3 and rOCT2 after hyperuricemia in the rat kidney.2005

    • Author(s)
      Habu, Y. et al.
    • Journal Title

      Biochem.Pharmacol. 69-6

      Pages: 993-999

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Altered pharmacokinetics of paclitaxel in experimental hepatic or renal failure.2005

    • Author(s)
      Jiko, M. et al.
    • Journal Title

      Pharm.Res. 22-2

      Pages: 228-234

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Metformin transport by renal basolateral organic cation transporter hOCT2.2005

    • Author(s)
      Kimura, N. et al.
    • Journal Title

      Pharm.Res. 22-2

      Pages: 255-259

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Transient up-regulation of P-glycoprotein reduces tacrolimus absorption after ischemia-reperfusion injury in rat ileum.2005

    • Author(s)
      Omae, T. et al.
    • Journal Title

      Biochem.Pharmacol. 69-4

      Pages: 561-568

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Distinct Inhibitory Effects of Tacrolimus and Cyclosporin A on Calcineurin Phosphatase Activity.2005

    • Author(s)
      Fukudo, M.
    • Journal Title

      J.Pharmacol.Exp.Ther. 312・2

      Pages: 816-825

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Restored expression and activity of organic ion transporters rOAT1,rOAT3 and rOCT2 after hyperuricemia in the rat kidney.2005

    • Author(s)
      Habu, Y.
    • Journal Title

      Biochem.Pharmacol 69・6

      Pages: 993-999

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Transient up-regulation of P-glycoprotein reduces tacrolimus absorption after ischemia-reperfusion injury in rat ileum.2005

    • Author(s)
      Omae, T.
    • Journal Title

      Biochem.Pharmacol. 69・4

      Pages: 561-568

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Increased protein level of PEPT1 intestinal H+-peptide cotransporter upregulates absorption of glycylsarcoisine and ceftibuten in 5/6 nephrectomized rats.2005

    • Author(s)
      Shimizu, Y.
    • Journal Title

      Am.J.Physiol.Gastrointest.Liver Physiol. 288・4

    • Related Report
      2004 Annual Research Report
  • [Journal Article] CYP3A5^*1-carrying graft liver reduces the concentration/oral dose ratio of tacrolimus in recipients of living-donor liver transplantation.2004

    • Author(s)
      Goto, M.
    • Journal Title

      Pharmacogenetics 14

      Pages: 471-478

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Gene expression variance based on random sequencing in rat remnant kidney.2004

    • Author(s)
      Horiba, N.
    • Journal Title

      Kidney Int. 66

      Pages: 29-45

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Efflux properties of basolateral peptide transporter in human intestinal cell line Caco-2.2004

    • Author(s)
      Irie, M.
    • Journal Title

      Pflugers Arch. 449

      Pages: 186-194

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Different transport properties between famotidine and cimetidine by human renal organic ion transporters (SLC22A).2004

    • Author(s)
      Motohashi, H.
    • Journal Title

      Eur.J.Pharmacol. 503

      Pages: 25-30

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Decreased expression of glucose and peptide transporters in rat remnant kidney.2004

    • Author(s)
      Nakamura, N.
    • Journal Title

      Drug Metab.Pharmacokinet. 19

      Pages: 41-47

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Surgical resection deteriorates gemcitabine-induced leukopenia in pancreatic cancer.2004

    • Author(s)
      Onoue, M.
    • Journal Title

      Int.J.Clin.Oncol. 9

      Pages: 174-178

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] The diurnal rhythm of the intestinal transporters SGLT1 and PEPT1 is regulated by the feeding conditions in rats.2004

    • Author(s)
      Pan, X.
    • Journal Title

      J.Nutr. 134

      Pages: 2211-2215

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Expression levels of renal organic anion transporters (OATs) and their correlation with anionic drug secretion in patients with renal diseases.2004

    • Author(s)
      Sakurai, Y.
    • Journal Title

      Pharm.Res.C 21

      Pages: 61-67

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Lansoprazole-Tacrolimus Interaction in Japanese Transplant Recipient with CYP2C19 Polymorphism.2004

    • Author(s)
      Takahashi, K.
    • Journal Title

      Ann.Pharmacother. 38

      Pages: 791-794

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Genetic variant Arg57His in human H+/peptide cotransporter 2 causes a complete loss of transport function.2004

    • Author(s)
      Terada, T.
    • Journal Title

      Biochem.Biophys.Res.Commun. 316

      Pages: 416-420

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Creatinine transport by basolateral organic cation transporter hOCT2 in the human kidney.2004

    • Author(s)
      Urakami, Y.
    • Journal Title

      Pharm.Res. 21

      Pages: 976-981

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Common single nucleotide polymorphisms of the MDR1 gene have no influence on its mRNA expression level of normal kidney cortex and renal cell carcinoma in Japanese nephrectomized patients.2004

    • Author(s)
      Uwai, Y.
    • Journal Title

      J.Hum.Genet. 49

      Pages: 40-45

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Methotrexate-loxoprofen interaction : involvement of human organic anion transporters hOAT1 and hOAT3.2004

    • Author(s)
      Uwai, Y.
    • Journal Title

      Drug Metab.Pharmacokinet. 19

      Pages: 369-374

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] CYP3A5^*1-carrying graft liver reduces the concentration/oral dose ratio of tacrolimus in recipients of living-donor liver transplantation.2004

    • Author(s)
      Goto, M. et al.
    • Journal Title

      Pharmacogenetics 14-7

      Pages: 471-478

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Gene expression variance based on random sequencing in rat remnant kidney.2004

    • Author(s)
      Horiba, N. et al.
    • Journal Title

      Kidney Int. 66-1

      Pages: 29-45

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Efflux properties of basolateral peptide transporter in human intestinal cell line Caco-2.2004

    • Author(s)
      Irie, M. et al.
    • Journal Title

      Pflugers Arch. 449-2

      Pages: 186-194

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Different transport properties between famotidine and cimetidine by human renal organic ion transporters (SLC22A).2004

    • Author(s)
      Motohashi, H. et al.
    • Journal Title

      Eur.J.Pharmacol. 503-1-3

      Pages: 25-30

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Decreased expression of glucose and peptide transporters in rat remnant kidney.2004

    • Author(s)
      Nakamura, N. et al.
    • Journal Title

      Drug Metab.Pharmacokinet. 19-1

      Pages: 41-47

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Surgical resection deteriorates gemcitabine-induced leukopenia in pancreatic cancer.2004

    • Author(s)
      Onoue, M. et al.
    • Journal Title

      Int.J.Clin.Oncol. 9-3

      Pages: 174-178

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] The diurnal rhythm of the intestinal transporters SGLT1 and PEPT1 is regulated by the feeding conditions in rats.2004

    • Author(s)
      Pan, X.et al.
    • Journal Title

      J.Nutr. 134-9

      Pages: 2211-2215

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Expression levels of renal organic anion transporters(OATs) and their correlation with anionic drug secretion in patients with renal diseases.2004

    • Author(s)
      Sakurai, Y. et al.
    • Journal Title

      Pharm.Res. 21-1

      Pages: 61-67

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Lansoprazole-Tacrolimus Interaction in Japanese Transplant Recipient with CYP2C19 Polymorphism.2004

    • Author(s)
      Takahashi, K. et al.
    • Journal Title

      Ann.Pharmacother. 38-5

      Pages: 791-794

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Genetic variant Arg57His in human H+/peptide cotransporter 2 causes a complete loss of transport function.2004

    • Author(s)
      Terada, T. et al.
    • Journal Title

      Biochem.Biophys.Res.Commun. 316,-2

      Pages: 416-420

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Creatinine transport by basolateral organic cation transporter hOCT2 in the human kidney.2004

    • Author(s)
      Urakami, Y. et al.
    • Journal Title

      Pharm.Res. 21-6

      Pages: 976-981

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Common single nucleotide polymorphisms of the MDR1 gene have no influence on its mRNA expression level of normal kidney cortex and renal cell carcinoma in Japanese nephrectomized patients.2004

    • Author(s)
      Uwai, Y. et al.
    • Journal Title

      J.Hum.Genet. 49-1

      Pages: 40-45

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Methotrexate-loxoprofen interaction : involvement of human organic anion transporters hOAT1 and hOAT3.2004

    • Author(s)
      Uwai, Y. et al.
    • Journal Title

      Drug Metab.Pharmacokinet. 19-5

      Pages: 369-374

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] CYP3A5^*1-carrying graft liver reduces the concentration/oral dose ratio of tacrolimus in recipients of living-donor liver transplantation.2004

    • Author(s)
      Goto, M.
    • Journal Title

      Pharmacogenetics 14・7

      Pages: 471-478

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Gene expression variance based on random sequencing in rat remnant kidney.2004

    • Author(s)
      Horiba, N.
    • Journal Title

      Kidney Int. 66・1

      Pages: 29-45

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Efflux properties of basolateral peptide transporter in human intestinal cell line Caco-2.2004

    • Author(s)
      Irie, M.
    • Journal Title

      Pflugers Arch. 449・2

      Pages: 186-194

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Different transport properties between famotidine and cimetidine by human renal organic ion transporters (SLC22A).2004

    • Author(s)
      Motohashi, H.
    • Journal Title

      Eur.J.Pharmacol. 503・1-3

      Pages: 25-30

    • Related Report
      2004 Annual Research Report
  • [Journal Article] The diurnal rhythm of the intestinal transporters SGLT1 and PEPT1 is regulated by the feeding conditions in rats.2004

    • Author(s)
      Pan, X.
    • Journal Title

      J.Nutr. 134・9

      Pages: 2211-2215

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Lansoprazole-Tacrolimus Interaction in Japanese Transplant Recipient with CYP2C19 Polymorphism.2004

    • Author(s)
      Takahashi, K.
    • Journal Title

      Ann.Pharmacother. 38・5

      Pages: 791-794

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Genetic variant Arg57His in human H+/peptide cotransporter 2 causes a complete loss of transport function.2004

    • Author(s)
      Terada, T.
    • Journal Title

      Biochem.Biophys.Res.Commun. 316・2

      Pages: 416-420

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Creatinine transport by basolateral organic cation transporter hOCT2 in the human kidney.2004

    • Author(s)
      Urakami, Y.
    • Journal Title

      Pharm.Res. 21・6

      Pages: 976-981

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Methotrexate-loxoprofen interaction : involvement of human organic anion transporters hOATl1 and hOAT3.2004

    • Author(s)
      Uwai, Y.
    • Journal Title

      Drug Metab.Pharmacokinet. 19・5

      Pages: 369-374

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Surgical resection deteriorates gemcitabine-induced leukopenia in pancreatic cancer.2004

    • Author(s)
      Onoue, M.
    • Journal Title

      Int.J.Crin.Oncol. 9・3

      Pages: 174-178

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Decreased activity of basolateral organic ion transports in hyperuricemic rat kidney : roles of organic ion transporters, rOAT1, rOAT3 and rOCT2.2003

    • Author(s)
      Habu, Y.
    • Journal Title

      Biochem.Pharmacol. 66

      Pages: 1107-1114

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Na(+)-dependent fructose transport via rNaGLT1 in rat kidney.2003

    • Author(s)
      Horiba, N.
    • Journal Title

      FEBS Lett. 546

      Pages: 276-280

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Cloning and characterization of a novel Na+-dependent glucose transporter NaGLT1 in rat kidney.2003

    • Author(s)
      Horiba, N.
    • Journal Title

      J Biol.Chem. 278

      Pages: 14669-14676

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Altered diurnal rhythm of intestinal peptide transporter by fasting and its effects on the pharmacokinetics of ceftibuten.2003

    • Author(s)
      Pan, X.
    • Journal Title

      J Pharmacol.Exp.Ther. 307

      Pages: 626-632

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Decreased function of genetic variants, Pro283Leu and Arg287Gly, in human organic cation transporter hOCT1.2003

    • Author(s)
      Takeuchi, A.
    • Journal Title

      Drug Metab.Pharmacokinet. 18

      Pages: 409-412

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Decreased activity of basolateral organic ion transports in hyperuricemic rat kidney : roles of organic ion transporters, rOAT1,rOAT3 and rOCT2.2003

    • Author(s)
      Habu, Y. et al.
    • Journal Title

      Biochem.Pharmacol. 66-6

      Pages: 1107-1114

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Na(+)-dependent fructose transport via rNaGLT1 in rat kidney.2003

    • Author(s)
      Horiba, N. et al.
    • Journal Title

      FEBS Lett. 546-2-3

      Pages: 276-280

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Cloning and characterization of a novel Na+-dependent glucose transporter NaGLT1 in rat kidney.2003

    • Author(s)
      Horiba, N. et al.
    • Journal Title

      J.Biol.Chem. 278-17

      Pages: 14669-14676

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Altered diurnal rhythm of intestinal peptide transporter by fasting and its effects on the pharmacokinetics of ceftibuten.2003

    • Author(s)
      Pan, X.et al.
    • Journal Title

      J.Pharmacol.Exp.Ther. 307-2

      Pages: 626-632

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Decreased function of genetic variants, Pro283Leu and Arg287Gly, in human organic cation transporter hOCT1.2003

    • Author(s)
      Takeuchi, A. et al.
    • Journal Title

      Drug Metab.Pharmacokinet. 18-6

      Pages: 409-412

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Book] 改訂 腎機能別薬剤使用マニュアル2003

    • Author(s)
      土井俊夫ら
    • Total Pages
      194
    • Publisher
      じほう
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Publications] Urakami et al.: "Creatinine transport by basolateral organic cation transporter hOCT2 in the human kidney"Pharm.Res.. (印刷中). (2004)

    • Related Report
      2003 Annual Research Report
  • [Publications] Horiba et al.: "Gene expression variance based on random sequencing in rat remnant kidney"Kidney Int.. (印刷中). (2004)

    • Related Report
      2003 Annual Research Report
  • [Publications] Onoue et al.: "Surgical resection deteriorates gemcitabine-induced leukopenia in pancreatic cancer"Int.J.Clin.Oncol.. (印刷中). (2004)

    • Related Report
      2003 Annual Research Report
  • [Publications] Takahashi et al.: "Lansoprazole-tacrolimus interaction in Japanese transplant recipient with CYP2C19 polymorphism"Ann.Pharmacother.. (印刷中). (2004)

    • Related Report
      2003 Annual Research Report
  • [Publications] Terada et al.: "Genetic variant Arg57His in human H^+/peptide cotransporter 2 causes a complete loss of transport function"Biochem.Biophys.Res.Commun.. 315・2. 416-420 (2004)

    • Related Report
      2003 Annual Research Report
  • [Publications] Nakamura et al.: "Decreased expression of glucose and peptide transporters in rat remnant kidney"Drug Metab.Pharmacokin.. 19・1. 41-47 (2004)

    • Related Report
      2003 Annual Research Report
  • [Publications] Sakurai et al.: "Expression levels of renal organic anion transporters (OATs) and their correlation with anionic drug secretion in patients with renal diseases"Pharm.Res.. 21・1. 61-67 (2004)

    • Related Report
      2003 Annual Research Report
  • [Publications] Uwai et al.: "Common single nucleotide polymorphisms of the MDR1 gene have no influence on its mRNA expression level of normal kidney cortex and renal cell carcinoma in Japanese nephrectomized patients"J.Hum.Genet.. 49・1. 40-45 (2004)

    • Related Report
      2003 Annual Research Report
  • [Publications] Habu et al.: "Decreased activity of basolateral organic ion transports in hyperuricemic rat kidney : Roles of organic ion transporters, rOAT1, rOATS and rOCT2"Biochem.Pharmacol.. 66・6. 1107-1114 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Pan et al.: "Altered diurnal rhythm of intestinal peptide transporter by fasting and its effects on the pharmacokinetics of ceftibuten"J.Pharmacol.Exp.Ther.. 307・2. 626-632 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Takeuchi et al.: "Decreased function of genetic variants, Pro283Leu and Arg287Gly, in human organic cation transporter hOCT1"Drug Metab.Pharmacokin.. 18・6. 409-412 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Horiba et al.: "Na^+-dependent fructose transport via rNaGLT1 in rat kidney"FEBS Lett.. 546・2-3. 276-280 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Horiba et al.: "Cloning and characterization of a novel Na^+-dependent glucose transporter NaGLT1 in rat kidney"J.Biol.Chem.. 278・17. 14669-14676 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] 土井俊夫: "改訂 腎機能別薬剤使用マニュアル"じほう. 194 (2003)

    • Related Report
      2003 Annual Research Report

URL: 

Published: 2003-04-01   Modified: 2016-04-21  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi