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The monoaminergic modulation of spinal motor function and the alteration in the motor disease

Research Project

Project/Area Number 15590134
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Medical pharmacy
Research InstitutionNagoya City University

Principal Investigator

ONO Hideki  Nagoya City University, Faculty of Pharmaceutical Sciences, Professor, 大学院・薬学研究科, 教授 (00080200)

Co-Investigator(Kenkyū-buntansha) TANABE Mitsuo  Nagoya City Univeisity, Faculty of Pharmaceutical Sciences, Assistant Professor, 大学院・薬学研究科, 助教授 (20360026)
HONDA Motoko  Nagoya City University, Faculty of Pharmaceutical Sciences, Reserch Assistant, 大学院・薬学研究科, 助手 (30297626)
Project Period (FY) 2003 – 2004
Project Status Completed (Fiscal Year 2004)
Budget Amount *help
¥3,600,000 (Direct Cost: ¥3,600,000)
Fiscal Year 2004: ¥1,300,000 (Direct Cost: ¥1,300,000)
Fiscal Year 2003: ¥2,300,000 (Direct Cost: ¥2,300,000)
Keywordsdescending monoaminergic systems / noradrenaline / serotonin / spinal motors stem / motor disease / spinocerebellar atrophy / 脊椎小脳変性症
Research Abstract

The descending noradrenergic and serotonergic systems modulate the function of the spinal α-motoneurons which control movements of body and limbs. However, the function and changes in neuronal disease are unclear. In the present study, the following results were obtained.
1. Serotonergic agonists have been shown both to increase and decrease spinal motor transmission. Motoneurons possess somatodendritic serotonin (5-HT)_2 receptors, which account for the increased excitability. However, it is unclear which receptor subtypes mediate the inhibitory effects on spinal reflexes. We showed that 5-HT_<1B> and 5-HT_<1D> receptors located in the spinal cord mediate the 5-HT-induced inhibition of spinal reflexes.
2. Spinal reflexes and recurrent and presynaptic inhibitions in streptozotocin (STZ)-induced diabetic rats were examined. The recurrent inhibition which is mediated by glycine was depressed in diabetic rats. In addition, the inhibitory effect of 5-HT was decreased in those rats. These res … More ults show that the diabetogenic degeneration occurred in not only sensory but also motor systems.
3. The relationships between ataxia and the monoamines concentrations of central nervous systems were examined in spinocerebellar atrophy (SCD) model mice. Two SCD model mice, rolling mouse Nagoya (RMN) and Ara-C mice which were produced by the administration of cytosine arabinoside on 2, 3, 4 days after birth, were used. The concentrations of monoamines were increased in CNS of these SCD model mice. The repeated administration of taltirelin hydrate, which is clinically used for SCD treatment, improved ataxia, but did not affect the monoamines concentration of CNS in RMN and Ara-C mice.
4. We showed that the noxious stimuli-evoked flexor reflex of mice were composed from Aδ-fiber mediated short-latency and C-fiber-mediated long-latency withdrawal movements. These withdrawal movements are facilitated by repeated stimulation, it is called wind-up. In STZ-induced diabetic mice, the wind-up of C-fiber-mediated movement, but not Aδ-fiber-mediated one, was enhanced significantly. Less

Report

(3 results)
  • 2004 Annual Research Report   Final Research Report Summary
  • 2003 Annual Research Report
  • Research Products

    (12 results)

All 2005 2004 2003 Other

All Journal Article (10 results) Publications (2 results)

  • [Journal Article] Enhanced wind-up of the C-fiber-mediated nociceptive flexor reflex movement following painful diabetic neuropathy in mice2005

    • Author(s)
      Kimura, S. et al.
    • Journal Title

      J.Pharmacological Sciences 97

      Pages: 195-202

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Enhanced wind-up of the C-fiber-mediated nociceptive flexor reflex movement following painful diabetic neuropathy in mice2005

    • Author(s)
      S.Kimura et al.
    • Journal Title

      J. of Pharmacological Sciences 97

      Pages: 195-202

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Enhanced wind-up of the C-fiber-mediated nociceptive flexor reflex movement following painful diabetic neuropathy in mice2005

    • Author(s)
      Kimura, S., Tanabe, M., Honda, M., Ono, H.
    • Journal Title

      J.Pharmacological Science 97

      Pages: 195-202

    • NAID

      10025725911

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Endogenously released 5-hydroxytryptamine depress the spinal mono-synaptic reflex via 5-HT_<1D> receptors2004

    • Author(s)
      Honda, M. et al.
    • Journal Title

      Eur.J.Pharmacology 503

      Pages: 55-61

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Noxious stimuli evoke a biphasic flexor reflex composed of Aδ-fiber-mediated short-latency and C-fiber-mediated long-latency withdrawal movements in mice2004

    • Author(s)
      Kimura, S. et al.
    • Journal Title

      J.Pharmacological Sciences 95

      Pages: 94-100

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Noxious stimuli evoke a biphasic flexor reflex composed of Aδ-fiber-mediated short-latency and C-fiber-mediated long-latency withdrawal movements in mice2004

    • Author(s)
      S.Kimura et al.
    • Journal Title

      J. of Pharmacological Sciences 95

      Pages: 94-100

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Endogenously released 5-hydroxytryptamine depress the spinal monosynaptic reflex via 5-HT_<1D> receptors2004

    • Author(s)
      M.Honda et al.
    • Journal Title

      Eur. J. Pharmacol. 503

      Pages: 55-61

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Endogenously released 5-hydroxytryptamine depress the spinal monosynaptic reflex 5-HT_<1D> receptors2004

    • Author(s)
      Honda, M., Imaida, K., Tanabe, M., Ono, H.
    • Journal Title

      Eur.J.Pharmacology 503

      Pages: 55-61

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Serotonergic depression of spinal monosynaptic transmission is mediated by 5-HT_<1B> receptors.2003

    • Author(s)
      Honda, M. et al.
    • Journal Title

      Eur.J.Pharmacology 482

      Pages: 155-161

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Serotonergic depression of spinal monosynaptic transmission is mediated by 5-HT_<1B> receptors2003

    • Author(s)
      M.Honda et al.
    • Journal Title

      Eur. J. Pharmacol. 482

      Pages: 155-161

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Publications] Kimura, S., Honda, M., Tanabe, M., Ono, H.: "Noxious stimuli evoke a biphasic flexor reflex composed of AS-fiber-mediated short-latency and C-fiber-mediated long latency withdrowal movements in mice"J.of Pharmacological Sciences. (2004)

    • Related Report
      2003 Annual Research Report
  • [Publications] Honda, M., Tanabe, M., Ono H.: "Serotonergic depression of spinal monosynaptic transmission is mediated by 5-HT_<1B> receptors"Eur.J.Pharmacology. 482. 155-161 (2003)

    • Related Report
      2003 Annual Research Report

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Published: 2003-04-01   Modified: 2016-04-21  

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