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Mechanisms of penile erection during REM sleep regulated by the hypothalamo-limbic system.

Research Project

Project/Area Number 15590211
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Environmental physiology (including Physical medicine and Nutritional physiology)
Research InstitutionFukushima Medical University

Principal Investigator

KOYAMA Yoshimasa  Fukushima University, Cluster of Science and technology, Professor, 共生システム理工学類, 教授 (80183812)

Co-Investigator(Kenkyū-buntansha) TAKAHASHI Kazumi  Fukushima Medical University., Dept. of Physiology, Research Associate, 医学部, 助手 (90325952)
KAYAMA Yukihiko  Fukushima Medical University, Dept of Physiology, Professor, 医学部, 教授 (30035224)
Project Period (FY) 2003 – 2004
Project Status Completed (Fiscal Year 2004)
Budget Amount *help
¥3,600,000 (Direct Cost: ¥3,600,000)
Fiscal Year 2004: ¥1,200,000 (Direct Cost: ¥1,200,000)
Fiscal Year 2003: ¥2,400,000 (Direct Cost: ¥2,400,000)
KeywordsPreoptic area / laterodorsal tegmental nucleus / limbic system / paraventricular nucleus / REM sleep / acetylcholine / penile erection / rat / 分界条床核
Research Abstract

To elucidate the mechanisms involved in regulation of penile erection during REM sleep, we electrically stimulated the proptic/hypothalamic areas, in and around the brainstem cholinergic neurons (larerodorsal tegmental nucleus, LDT) and recorded the neuronal activity in the LDT.
Spontaneous normal penile erection pattern is composed of slow increase of pressure in corpus spongeneosum of the penis (CSP) and sharp increase in CSP pressure synchronized with burstic bulbospongiosus (BS) muscle activity. In unanesthetized, head-restrained rats, penile erection which was almost similar to the normal spontaneous one was evoked after the electrical stimulation to the medial preoptic area (MPOA), lateral preoptic area (LPOA), paraventricular nucleus (PVN) or bed nucleus of stria terminalis (BST). Among them, latency of the response was shorter in the PVN. In urethane anesthetized rats, erection was evoked only from the MPOA and PVN. Erection was evoked also in and around the LDT. In some areas, the evoked erection pattern was almost normal, while in other areas only the slow increase in CSP pressure or sharp increase of CSP pressure and BS muscle activity was observed. Some of the the cholinergic neurons in the LDT showed phasic firing before the sharp CSP increase, while others showed tonic increase for several seconds before the initiation of erection.
These results indicate that lateral part and medial part of the preoptic area are involved in penile erection in different way. PVN is the final out put in the hypothalamus for penile erection. The LDT contains systems which selectively activate the component of penile erection and those which inhibit penile erection.

Report

(3 results)
  • 2004 Annual Research Report   Final Research Report Summary
  • 2003 Annual Research Report
  • Research Products

    (19 results)

All 2005 2004 2003 Other

All Journal Article (18 results) Publications (1 results)

  • [Journal Article] State-dependent effects of orexin on the serotonergic dorsal raphe neurons in the rat2005

    • Author(s)
      Takahashi K. et al.
    • Journal Title

      Regul.Peptide 126

      Pages: 43-47

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Annual Research Report 2004 Final Research Report Summary
  • [Journal Article] The orexinergic synaptic enervation of serotonin- and orexin 1 receptor-containing neurons in the dorsal raphe nucleus2005

    • Author(s)
      Wang Q.-P., Koyama Y.et al.
    • Journal Title

      Regul.Peptide 126

      Pages: 35-42

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Annual Research Report 2004 Final Research Report Summary
  • [Journal Article] State-dependent effects of orexin on the serotonergic dorsal raphe neurons in the rat2005

    • Author(s)
      Takahashi K., Wang O.-P., Guan J.-L., Kayama Y., Shioda S., Koyama Y.
    • Journal Title

      Regul. Peptide 126

      Pages: 43-47

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] The orexinergic synaptic enervation of serotonin- and orexin 1 receptor-containing neurons in the dorsal raphe nucleus2005

    • Author(s)
      Wang Q.-P., Koyama Y., Guan J.-L., Kayama Y., Takahashi K., Kayama Y, Shioda S.
    • Journal Title

      Reg. Peptide 126

      Pages: 35-42

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Is state-dependent alternation of slow dynamics in central single neurons during sleep present in the rat ventroposterior thalamic nucleus?2004

    • Author(s)
      Takahashi K., Koyama Y.et al.
    • Journal Title

      Neurosci.Res. 48

      Pages: 203-210

    • NAID

      10014233191

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Annual Research Report 2004 Final Research Report Summary
  • [Journal Article] Modulation of desmopressin of neuronal activity in brainstem micturition center2004

    • Author(s)
      Iwasaki H., Koyama Y.et al.
    • Journal Title

      Urology 63

      Pages: 994-998

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Annual Research Report 2004 Final Research Report Summary
  • [Journal Article] Is state-dependent alternation of slow dynamics in central single neurons during sleep present in the rat ventroposterior thalamic nucleus?2004

    • Author(s)
      Takahashi K., Koyama Y., Kayama Y., Nakamura K., Yamamoto M.
    • Journal Title

      Neurosci. Res. 48

      Pages: 203-210

    • NAID

      10014233191

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Modulation of desmopressin of neuronal activity in brainstem micturition center2004

    • Author(s)
      Iwasaki H., Koyama Y., Tanaka Y.Kawauchi A., Jodo E., Kayama Y., Miki T.
    • Journal Title

      Urology 63

      Pages: 994-998

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] State dependent activity of neurons in the perifornical hypothalamic area during sleep and waking.2003

    • Author(s)
      Koyama Y. et al.
    • Journal Title

      Neuroscience 119

      Pages: 1209-1219

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Annual Research Report 2004 Final Research Report Summary
  • [Journal Article] The cholinergic neurons in the brainstem are involved in fluctuation of blood pressure during paradoxical sleep2003

    • Author(s)
      Koyama Y. et al.
    • Journal Title

      Sleep and Biological Rhythms 1

      Pages: 105-106

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Annual Research Report 2004 Final Research Report Summary
  • [Journal Article] State-dependent alternation of neuronal slow dynamics in the rat ventroposterior thalamic area2003

    • Author(s)
      Takahashi K., Koyama Y.et al.
    • Journal Title

      Sleep and Biological Rhythms 1

      Pages: 101-103

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Annual Research Report 2004 Final Research Report Summary
  • [Journal Article] Nitric oxide, induced by kainite application, regulates norepinephrine release in the laterodorsal tegmental nucleus of rat2003

    • Author(s)
      Kodama T. et al.
    • Journal Title

      Sleep and Biological Rhythms 1

      Pages: 107-109

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Annual Research Report 2004 Final Research Report Summary
  • [Journal Article] Firing of micturition center neurons in the rat mesopontine tegmentum during urinary bladder contraction2003

    • Author(s)
      Tanaka Y., Koyama Y.et al.
    • Journal Title

      Brain Res. 965

      Pages: 146-154

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Annual Research Report 2004 Final Research Report Summary
  • [Journal Article] State dependent activity of neurons in the perifornical hypothalamic area during sleep and waking2003

    • Author(s)
      Koyama Y., Takahashi K.Kodama T., Kayama Y.
    • Journal Title

      Neuroscience 119

      Pages: 1209-1219

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] The cholinergic neurons in the brainstem are involved in fluctuation of blood pressure during paradoxical sleep2003

    • Author(s)
      Koyama Y., Takahashi K., Sei H., Kodama T., Kayama Y.
    • Journal Title

      Sleep and Biological Rhythms 1

      Pages: 105-106

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] State-dependent alternation of neuronal slow dynamics in the rat ventroposterior thalamic area2003

    • Author(s)
      Takahashi K., Koyama Y., Kayama Y., Yamamoto M.
    • Journal Title

      Sleep and Biological Rhythms 1

      Pages: 101-103

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Nitric oxide, induced by kainite application, regulates norepinephrine release in the laterodorsal tegmental nucleus of rats2003

    • Author(s)
      Kodama T., Honda Y., Koyama Y
    • Journal Title

      Sleep and Biological Rhythms 1

      Pages: 107-109

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Firing of micturition center neurons in the rat mesopontine tegmentum during urinary bladder contraction2003

    • Author(s)
      Tanaka Y., Koyama Y., Kayama Y., Kawauchi A., Ukimura O., Miki T.
    • Journal Title

      Brain Res. 965

      Pages: 146-154

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Publications] Y.Koyama, K.Takahashi, T.Kodama, Y.Kayama: "State dependent activity of neurons in the laterodorsal hypothalamic area during sleep and waking"Neuroscience. 119. 1209-1219 (2003)

    • Related Report
      2003 Annual Research Report

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Published: 2003-04-01   Modified: 2016-04-21  

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