Effect of tactile stimulation applied during infantile period on various autonomic functions in rats.
| Project/Area Number |
15590214
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Environmental physiology (including Physical medicine and Nutritional physiology)
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| Research Institution | International University of Health and Welfare |
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Principal Investigator |
KUROSAWA Mieko International University of Health and Welfare, Department of Health Sciences, Professor, 保健学部, 教授 (30178131)
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| Project Period (FY) |
2003 – 2005
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| Project Status |
Completed (Fiscal Year 2005)
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| Budget Amount *help |
¥3,300,000 (Direct Cost: ¥3,300,000)
Fiscal Year 2005: ¥900,000 (Direct Cost: ¥900,000)
Fiscal Year 2004: ¥1,000,000 (Direct Cost: ¥1,000,000)
Fiscal Year 2003: ¥1,400,000 (Direct Cost: ¥1,400,000)
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| Keywords | touch / autonomic function / stress / growth / blood pressure / heart rate / reflex responses / infantile period / 側坐核 / ドーパミン / 報酬系 / 脊髄血流 / 分節性反応 / 全身性反応 / ラット / 脊髄反射 / 交感神経 / 迷走神経 / 成長 / 摂食量 / 皮膚 |
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| Research Abstract |
The objective of this study was to investigate the effect of repeated tactile stimulation applied during infantile period on various autonomic functions. The experiments were performed in rats. The tactile stimulation was applied by stroking manually the abdominal skin area for 5 min every day during 4 weeks after 25 days of age. Following results were obtained.
1.Repeated massage-like stroking prevented stress-induced retardation of growth. The effects were not observed under food restriction, suggesting that the effects of tactile stimulation on body weight were mediated via modulation of food intake.
2.Repeated massage-like stroking augmented spinal autonomic responses of blood pressure and heart rate to noxious pinching; however, the treatment showed no changes in these responses in the rats with intact central nervous system, suggesting that the repeated massage-like stroking might augment descending inhibitory pathways on spinal reflex arcs.
3.Repeated massage-like stroking had no influence on the responses of dopamine release from the nucleus accumbens, which is known to influence autonomic functions, to innocuous brushing and noxious pinching.
These results indicate that tactile stimulation applied during infantile period can affect various autonomic functions.
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Report
(4 results)
Research Products
(38 results)
