| Project/Area Number |
15590222
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
General pharmacology
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| Research Institution | University of Yamanashi |
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Principal Investigator |
SUGIYAMA Atsushi University of Yamanashi, Department of Research Interdisciplinary Graduate School of Medicine & Engineering, Associate professor, 大学院・医学工学総合研究部, 助教授 (60242632)
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| Project Period (FY) |
2003 – 2004
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| Project Status |
Completed (Fiscal Year 2004)
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| Budget Amount *help |
¥3,600,000 (Direct Cost: ¥3,600,000)
Fiscal Year 2004: ¥1,700,000 (Direct Cost: ¥1,700,000)
Fiscal Year 2003: ¥1,900,000 (Direct Cost: ¥1,900,000)
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| Keywords | Long QT syndrome / Lathal arrhythmias / Drug / Safety Pharmacology / Complete AV block / 徐脈 / ホルター心電図 / QT延長 / 多型性心室頻拍 / torsades de pointes / 安全域 / 慢性房室ブロック犬モデル |
|---|
| Research Abstract |
Torsadogenic potential of the QT interval prolonging drugs (sematilide, nifekalant, amiodarone, cisapride, terfenadine, sulpiride and sparfloxacin) was assessed using the chronic complete atrioventricular block dogs under the Holter ECG monitoring in conscious state (n=4-6 for each drug). Oral administration of <10 times higher of respective clinically relevant doses of the drugs induced torsades de pointer (TdP) except for amiodarone. These results indicate that the chronic atrioventricular block dog can become a useful strategy in estimating dangerous QT prolongation.
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