| Budget Amount *help |
¥3,400,000 (Direct Cost: ¥3,400,000)
Fiscal Year 2004: ¥900,000 (Direct Cost: ¥900,000)
Fiscal Year 2003: ¥2,500,000 (Direct Cost: ¥2,500,000)
|
|---|
| Research Abstract |
We studied three cases of Lennert's lymphoma showing aggressive clinical course. These cases were also accompanied by disseminated intravascular coagulation(DIC) or hemophagocytic syndrome(HPS). We also compared these cases with non-aggressive type of Lennert's lymphoma. Of the three cases we experienced, two had lymphoma cell involvement in the liver and two in the bone marrow. In one case, a lymph node biopsy revealed Lennert's lymphoma histologically, however, liver biopsy obtained several weeks later revealed high grade large cell cytotoxic T cell lymphoma. Three cases showed hemophagocytic syndrome and the one showed DIC. Most of them died within a year after diagnosis, the shortest being 1.5 months. Immunohistochemically, all cases exhibited CD8+,CD4-, granzyme B+, and TIA-1+, showing cytotoxic T cell phenotype. Two cases showed positive reactivity for EB virus in the lymphoma cells with in situ hybridization. We also compared these cases with eight cases of non-aggressive type of Lennert's lymphoma. Compared with the latter, our four cases had higher count of MIB-1 positive lymphoma cells. In conclusion, our current study revealed that some cases of Lennert's lymphoma share common features with high grade cytotoxic T cell lymphoma. This indicate that Lennert's lymphoma may be a part of the spectrum of cytotoxic T cell lymphoma.
|
