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Prediction of CHOP therapy resistance in diffuse large B cell lymphoma: a genome-wide cDNA microarray analysis.

Research Project

Project/Area Number 15590325
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Human pathology
Research InstitutionFukuoka University

Principal Investigator

SUZUMIYA Junji  Fukuoka University, School of Medicine, Associate Professor, 医学部, 助教授 (70206556)

Co-Investigator(Kenkyū-buntansha) OHSHIMA Koichi  Fukuoka University, School of Medicine, Associate Professor, 医学部, 助教授 (50203766)
NABESHIMA Kazuki  Fukuok University, School of Medicine, Associate Professor, 医学部, 助教授 (40189189)
Project Period (FY) 2003 – 2004
Project Status Completed (Fiscal Year 2004)
Budget Amount *help
¥3,400,000 (Direct Cost: ¥3,400,000)
Fiscal Year 2004: ¥1,600,000 (Direct Cost: ¥1,600,000)
Fiscal Year 2003: ¥1,800,000 (Direct Cost: ¥1,800,000)
Keywordsnon-Hodgkin's lymphoma / Diffuselarge B cell lymphoma / Chemotherapy / CHOP therapy / Chemo-resistance / DNA microarray / 悪性リンパ腫 / DLBCL / cDNAマイクロアレイ / mRNA / 非ホジキンシンパ腫 / びまん性大細胞型B細胞リンパ腫
Research Abstract

[Background and Purpose] The standard therapy is cyclophosphamide, doxorubicin, vincristine, and prednisone (CHOP) therapy for advanced diffuse large B-cell lymphoma (DLBCL) patients. About 80% patients of DLBCL reach the remission by CHOP therapy, but the remain of patients are resistant to this therapy. We studied the difference of genetic characteristics between the chemo-sensitive and chemo-resistant groups using cDNA microarray
[Patients and Methods] We selected 6 patients of CHOP-sensitive and 7 of CHOP-resistant DLBCL. We analyzed the gene expression profile of both CHOP-sensitive and CHOP-resistant groups by cDNA microarray using Cancer chip version 4.0 (Takara Bio company, Otsu, Japan).
[Results] To clarify CHOP-resistant predictor genes, we chose genes that were differentially expressed between CHOP-resistant and sensitive groups (p<0.05) in student t-test. Moreover, we selected the genes within these genes, which of CHOP-resistant group were differentiated positively or negatively more than three times of that of CHOP-sensitive group. Hierarchical clustering showed the clearly different pattern in CHOP-resistant and sensitive groups using these selected genes. There were 8 up-regulated genes included PRAME (Preferentially expressed antigen of melanoma) in CHOP-resistant group and one down-regulated gene, CD79a in CHOP-sensitive group. Furthermore, we studied the relationship, between the expression of PRAME and clinical course using RT-PCR. PRAME was positive in 23 of 77 patients with DLBCL. The survival of PRAM E positive patients was shorter than that of PRAME negative patients (p=0.0565). PRAME was positive in 12 of 45 patients having disease free survival. The prognosis of PRAME positive patients was significantly poorer than that of negative patients (p=0.037).
[Conclusion] The expression of PRAME predicts the resistance of CHOP therapy in DLBCL

Report

(3 results)
  • 2004 Annual Research Report   Final Research Report Summary
  • 2003 Annual Research Report
  • Research Products

    (52 results)

All 2005 2004 2003 Other

All Journal Article (48 results) Publications (4 results)

  • [Journal Article] A "floral" variant of nodal marginal zone lymphoma2005

    • Author(s)
      Karube K, --Suzumiya J, (6番目他6名)
    • Journal Title

      Human Pathol 36

      Pages: 202-206

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Clinicopathological features of cutaneous lesions of adult T-cell leukaemia/lymphoma2005

    • Author(s)
      Yamaguchi T, --, Suzumiya J, (9番目, 他12名)
    • Journal Title

      Br J Dermatol 152

      Pages: 76-81

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] CXCR3-positive B cells found at elevated frequency in the peripheral blood of patients with MALT lymphoma are attracted by MIG and belong to the lymphoma clone2005

    • Author(s)
      Suefuji H, --, Suzumiya J, (6番目他6名)
    • Journal Title

      Int J Cancer 114

      Pages: 896-901

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] A "floral" variant of nodal marginal zone lymphoma.2005

    • Author(s)
      Karube K, Ohshima K, Tsuchiya T, Yamaguchi T, Kawano R, Suzumiya J, Harada M, Kikuchi M
    • Journal Title

      Human Pathol 36

      Pages: 202-206

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Clinicopathological features of cutaneous lesions of adult T-cell leukaemia/lymphoma.2005

    • Author(s)
      Yamaguchi T, Ohshima K, Karube K, Tutiya T, Kawano R, Suefuji H, Shimizu A, Nakayama J, Suzumiya J, Moroi Y, Urabe K, Furue M, Koga T, Kikuchi M
    • Journal Title

      Br J Dermatol 152

      Pages: 76-81

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] CXCR3-positive B cells found at elevated frequency in the peripheral blood of patients with MALT lymphoma are attracted by MIG and belong to the lymphoma clone.2005

    • Author(s)
      Suefuji H, Ohshima K, Karube K, Kawano R, Nabeshima K, Suzumiya J, Hayabuchi N, Kikuchi M
    • Journal Title

      Int J Cancer 114

      Pages: 896-901

    • NAID

      40015524515

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] CXCR3-positive B cells found at elevated frequency in the peripheral blood of patients with MALT lymphoma are attracted by MIG and belong to the lymphoma clone2005

    • Author(s)
      Suzumiya J, (6番目, 他7名)
    • Journal Title

      Int J Cancer 114

      Pages: 896-901

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Fluid retention during thalidomide therapy for refractory multiple myelomas.2004

    • Author(s)
      Kumagawa M, Suzumiya J, (2番目, 他5名)
    • Journal Title

      J Clin Experiment Hematopathol 44

      Pages: 63-66

    • NAID

      10014316347

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Gene expression in adult T cell leukemia/lymphoma : up-regulation of matrix mettallopreteinase 2 in skin lesions.2004

    • Author(s)
      Karube K, --, Suzumiya J, (7番目, 他9名)
    • Journal Title

      J Clin Experiment Hematopathol 44

      Pages: 67-74

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Prognostic significance of hepatocyte growth factor and c-MET expression in patients with diffuse large B-cell lymphoma.2004

    • Author(s)
      Kawano R, --Suzumiya J, (6番目他6名)
    • Journal Title

      Br J Haematol 127

      Pages: 305-307

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Classification of distinct subtypes of peripheral T-cell lymphoma unspecified, identified by chemokine and chemokine receptor expression : Analysis of prognosis.2004

    • Author(s)
      Ohshima K, --, Suzumiya J, (7番目他6名)
    • Journal Title

      Int J Oncol 25

      Pages: 605-613

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Expression of FoxP3, a key molecule in CD4CD25 regulatory T cells, in adult T-cell leukaemia/lymphoma cells.2004

    • Author(s)
      Karube K--, Suzumiya J, (6番目他7名)
    • Journal Title

      Br J Haematol 126

      Pages: 81-84

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Th1,Th2, and activated T-cell marker and clinical prognosis in peripheral T-cell lymphoma, unspecified : comparison with AILD, ALCL, lymphoblastic lymphoma, and ATLL.2004

    • Author(s)
      Tsuchiya T, --, Suzumiya J, (8番目他8名)
    • Journal Title

      Blood 103

      Pages: 236-241

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Kyushu Hematology Organization for Treatment Study Group : Phase I study of the combination of irinotecan hydrochloride, carboplatin, and dexamethasone for the treatment of relapsed or refractory malignant lymphoma.2004

    • Author(s)
      Suzumiya J, (1番目他6名)
    • Journal Title

      Int J Hematol 79

      Pages: 266-270

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Clinicopathological states of Epstein-Barr virus-associated T/NK-cell lymphoproliferative disorders (severe chronic active EBV infection) of children and young adults.2004

    • Author(s)
      Suzuki K, --, Suzumiya J, (4番目他6名)
    • Journal Title

      Int J Oncol 24

      Pages: 1165-1174

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Emmprin, a cell surface inducer of matrix metalloproteinases (MMPs), is expressed in T-cell lymphomas2004

    • Author(s)
      Nabeshima K, Suzumiya J, (2番目他6名)
    • Journal Title

      J Pathol 202

      Pages: 341-351

    • NAID

      40015524509

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] NK-cell Tumor Study Group : Aggressive natural killer-cell leukemia revisited : large granular lymphocyte leukemia of cytotoxic NK cells.2004

    • Author(s)
      Suzuki R, Suzumiya J, (6番目他10名)
    • Journal Title

      Leukemia 18

      Pages: 763-770

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] 難治性血液疾患に対する同種造血幹細胞移植2004

    • Author(s)
      高松 泰, --, 鈴宮淳司, (11番目他10名)
    • Journal Title

      福岡大学医学紀要 31

      Pages: 97-106

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Fluid retention during thalidomide therapy for refractory multiple myelomas.2004

    • Author(s)
      Kumagawa M, Suzumiya J, Takamatsu Y, Shishime M, Shirahashi A, Kawano T, Tamura K
    • Journal Title

      J Clin Experiment Hematopathol 44

      Pages: 63-66

    • NAID

      10014316347

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Gene expression in adult T cellleukemia/lymphoma: up-regulation of matrix mettallopreteinase 2 in skin lesions.2004

    • Author(s)
      Karube K, Ohshima K, Hamasaki M, Tsuchiya T, Yamaguchi T, Suefugi H, Suzumiya J, Nabeshima K, Utsunomiya A, Harada M, Kikuchi M
    • Journal Title

      J Clin Experiment Hematop athol 44

      Pages: 67-74

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Prognostic significance of hepatocyte growth factor and c-MET expression in patients with diffuse large B-cell lymphoma.2004

    • Author(s)
      Kawano R, Ohshima K, Karube K, Yamaguchi T, Kohno S, Suzumiya J, Kikuchi M, Tamura K
    • Journal Title

      Br J Haematol 127

      Pages: 305-307

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Classification of distinct subtypes of peripheral T-cell lymphoma unspecified, identified bychemokine and chemokine receptor expression: Analysis of prognosis.2004

    • Author(s)
      Ohshima K, Karube K, Kawano R, Tsuchiya T, Suefuji H, Yamaguchi T, Suzumiya J, Kikuchii M
    • Journal Title

      Int J Oncol 25

      Pages: 605-613

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Expression of FoxP3, a key molecule in CD4CD25 regulatory T cells, in adult T-cell leukaemia/lymphoma cells.2004

    • Author(s)
      Karube K, Ohshima K, Tsuchiya T, Yamaguchi T, Kawano R, Suzumiya J, Utsunomiya A, Harada M, Kikuchi M
    • Journal Title

      Br J Haematol 126

      Pages: 81-84

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Kyushu Hematology Organization for Treatment Study Group : Phase I study of thecombination of irinotecan hydrochloride, carboplatin, and dexamethasone for the treatment of relapsed or refractory malignant lymphoma.2004

    • Author(s)
      Suzumiya J, Suzushima H, Maeda K, Okamura S, Utsunomiya A, Shibuya T, Tamura K
    • Journal Title

      Int J Hematol 79

      Pages: 266-270

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Clinicopathological states of Epstein-Barr virus-associated T/NK-cell lymphoproliferative disorders (severe chronic active EBV infection) of children and young adults.2004

    • Author(s)
      Suzuki K, Ohshima K, Karube K, Suzumiya J, Ohga S, Ishihara S, Tamura K, Kikuchi M
    • Journal Title

      Int J Oncol 24

      Pages: 1165-1174

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Emmprin, a cell surface inducer of matrix metalloproteinases (MMPs), is expressed in T-cell lymphomas.2004

    • Author(s)
      Nabeshima K, Suzumiya J, Nagano M, Ohshima K, Toole BP, Tamura K, Iwasaki H, Kikuchi M
    • Journal Title

      J Pathol 202

      Pages: 341-351

    • NAID

      40015524509

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] NK-cell Tumor Study Group. : Aggressive natural killer-cell leukemia revisited: large granular lymphocyte leukemia of cytotoxic NK cells.2004

    • Author(s)
      Suzuki R, Suzumiya J, Nakamura S, Aoki S, Notoya A, Ozaki S, Gondo H, Hino N, Mori H, Sugimori H, Kawa K, Oshimi K
    • Journal Title

      Leukemia 18

      Pages: 763-770

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Clinical results of allogeneic hemopoietic stem cell transplantation for hematological disorders.2004

    • Author(s)
      Takamatsu Y, Kumagawa M, Suzuki K, Wakamatsu S, Ishizu M, Shirahama S, Kawano T, Shirahashi A, Shishime M, Nibu K, Suzumiya J, Tamura K
    • Journal Title

      Med. Bull. Fukuoka Univ. (in Japanese with English abstract) 31

      Pages: 97-106

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Th1, Th2, and activated T-cell marker and clinical prognosis in peripheral T-cell lymphoma, unspecified: comparison with AILD, ALCL, lymphoblastic lymphoma, and ATLL.2004

    • Author(s)
      Tsuchiya T, Ohshima K, Karube K, Yamaguchi T, Suefuji H, Hamasaki M, Kawasaki C, Suzumiya J, Tomonaga M, Kikuchi M
    • Journal Title

      Blood 103

      Pages: 236-241

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Fluid retention during thalidomide therapy for refractory multiple myelomas2004

    • Author(s)
      Suzumiya J, (2番目, 他6名)
    • Journal Title

      J Clin Experiment Hematopathol 44

      Pages: 63-66

    • NAID

      10014316347

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Gene expression in adult T cell leukemia/lymphoma : up-regulation of matrix mettallopreteinase 2 in skin lesions2004

    • Author(s)
      Suzumiya J, (7番目, 他10名)
    • Journal Title

      J Clin Experiment Hematopathol 44

      Pages: 67-74

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Prognostic significance of hepatocyte growth factor and c-MET expression in patients with diffuse large B-cell lymphoma2004

    • Author(s)
      Suzumiya J, (6番目, 他7名)
    • Journal Title

      Br J Haematol 127

      Pages: 305-307

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Classification of distinct subtypes of peripheral T-cell lymphoma unspecified, identified by chemokine and chemokine receptor expression : Analysis of prognosis2004

    • Author(s)
      Suzumiya J, (7番目, 他7名)
    • Journal Title

      Int J Oncol 25

      Pages: 605-613

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Phase I study of the combination of irinotecan hydrochloride, carboplatin, and dexamethasone for the treatment of relapsed or refractory malignant lymphoma2004

    • Author(s)
      Suzumiya J, (1番目, 他6名)
    • Journal Title

      Int J Hematol 79

      Pages: 266-270

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Non-B, non-T neoplasms with lymphoblast morphology : further clarification and classification.2003

    • Author(s)
      Karube K, --, Suzumiya J, (6番目他6名)
    • Journal Title

      Am J Surg Pathol 27

      Pages: 1366-1374

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Downregulation of Bcl-xL and activation of caspases during retinoic acid-induced apoptosis in an adult T-cell leukemia cell line.2003

    • Author(s)
      Fujimura S, Suzumiya J, (2番目他3名)
    • Journal Title

      Hematol J 4

      Pages: 328-335

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Differential chemokine, chemokine receptor and cytokine expression in Epstein-Barr virus-associated lymphoproliferative diseases.2003

    • Author(s)
      Ohshima K, --, Suzumiya J, (8番目他8名)
    • Journal Title

      Leuk Lymphoma 44

      Pages: 1367-1378

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Imbalances of chemokines, chemokine receptors and cytokines in Hodgkin lymphoma : classical Hodgkin lymphoma vs.Hodgkin-like ATLL2003

    • Author(s)
      Ohshima K--, Suzumiya J, (7番目他6名)
    • Journal Title

      Int J Cancer 106

      Pages: 706-712

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Clinical and genetic characteristics of Japanese Burkitt lymphomas with or without leukemic presentation.2003

    • Author(s)
      Namiki T, --, Suzumiya J, (11番目他12名)
    • Journal Title

      Int J Hematol 77

      Pages: 490-498

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Primary colorectal T-cell lymphoma.2003

    • Author(s)
      Okada M, --, Suzumiya J, (3番目他8名)
    • Journal Title

      J Gastroenterol. 38

      Pages: 376-384

    • NAID

      10012737505

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] The comparison of expression of cutaneous lymphocyte-associated antigen (CLA), and Th1- and Th2-associated antigens in mycosis fungoides and cutaneous lesions of adult T-cell leukemia/lymphoma.2003

    • Author(s)
      Yamaguchi T, --, Suzumiya J, (7番目他7名)
    • Journal Title

      Eur J Dermatol 13

      Pages: 553-559

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] The comparison of expression of cutaneous lymphocyte-associated antigen (CLA), and Th1- and Th2-associated antigens in mycosis fungoides and cutaneous lesions of adult T-cell leukemia/lymphoma.2003

    • Author(s)
      Yamaguchi T, Ohshima K, Tsuchiya T, Suehuji H, Karube K, Nakayama J, Suzumiya J, Yoshino T, Kikuchi M
    • Journal Title

      Eur J Dermatol 13

      Pages: 553-559

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Non-B, non-T neoplasms with lymphoblast morphology: further clarification and classification.2003

    • Author(s)
      Karube K, Ohshima K, Tsuchiya T, Yamaguchi T, Suefuji H, Suzumiya J, Harada M, Kikuchi M
    • Journal Title

      Am J Surg Pathol 27

      Pages: 1366-1374

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Downregulation of Bcl-xL and activation of caspases during retinoic acid-induced apoptosis in an adult T-cell leukemia cellline.2003

    • Author(s)
      Fujimura S, Suzumiy J, Yamada Y, Kuroki M, Ono J
    • Journal Title

      Hematol J 4

      Pages: 328-335

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Differential chemokine, chemokine receptor and cytokine expression in Epstein-Barr virus- associated lymphoproliferative diseases.2003

    • Author(s)
      Ohshima K, Karube K, Hamasaki M, Tutiya T, Yamaguchi T, Suefuji H, Suzuki K, Suzumiya J, Ohga S, Kikuchi M
    • Journal Title

      Leuk Lymphoma 44

      Pages: 1367-1378

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Imbalances of chemokines, chemokine receptors and cytokines in Hodgkin lymphoma: classical Hodgkin lymphoma vs. Hodgkin-like ATLL.2003

    • Author(s)
      Ohshima K, Karube K, Hamasaki M, Suefuji H, Tutiya T, Yamaguchi T, Suzumiya J, Kikuchi M
    • Journal Title

      Int J Cancer 106

      Pages: 706-712

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Clinical and genetic characteristics of Japanese Burkitt lymphomas with or without leukemic presentation.2003

    • Author(s)
      Namiki T, Sakashita A, Kobayashi H, Maseki N, Izumo T, Komada Y, Koizumi S, Shikano T, Kikuta A, Watanabe A, Suzumiya J, Kikuchi M, Kaneko Y
    • Journal Title

      Int J Hematol 77

      Pages: 490-498

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Primary colorectal T-cell lymphoma.2003

    • Author(s)
      Okada M, Maeda K, Suzumiya J, Hagimoto T, Wakamatsu S, Ohshima K, Kanda M, Sonoda T, Sakamoto A, Tamura K
    • Journal Title

      J Gastroenterol 38

      Pages: 376-384

    • NAID

      10012737505

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Publications] Nabeshima K., Suzumiya J., et al.: "Emmprin, a cell surface inducer of matrix metalloproteinases (MMPs), is expressed in T-cell lymphomas"Journal of Pathology. 202. 341-351 (2004)

    • Related Report
      2003 Annual Research Report
  • [Publications] Tsuchiya T., Suzumiya J.(他8名): "Th1, Th2, and activated T-cell marker and clinical prognosis in peripheral T-cell lymphoma, unspecified : comparison with AILD, ALCL, lymphoblastic lymphoma, and ATLL"Blood. 103. 236-241 (2004)

    • Related Report
      2003 Annual Research Report
  • [Publications] Karube K., Suzumiya J.(他6名): "Non-B, non-T neoplasms with lymphoblast morphology : further clarification and classification"American Journal of Surgical Pathology. 27. 1366-1374 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Fujimura S., Suzumiya J.(他3名): "Downregulation of Bcl-xL and activation of caspases during retinoic acid-induced apoptosis in an adult T-cell leukemia cell line"The Hematology Journal. 4. 328-335 (2003)

    • Related Report
      2003 Annual Research Report

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Published: 2003-04-01   Modified: 2016-04-21  

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