| Project/Area Number |
15590333
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Experimental pathology
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| Research Institution | Niigata University |
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Principal Investigator |
HASEGAWA Go Niigata University, Graduate School of Medical and Dental Sciences, Lecturer, 大学院・医歯学総合研究科, 講師 (90251800)
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| Co-Investigator(Kenkyū-buntansha) |
NAITO Makoto Niigata University, Graduate School of Medical and Dental Sciences, Professor, 大学院・医歯学総合研究科, 教授 (30045786)
YAMAMOTO Takashi Niigata University, Graduate School of Medical and Dental Sciences, Assistant, 大学院・医歯学総合研究科, 助手 (70313517)
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| Project Period (FY) |
2003 – 2004
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| Project Status |
Completed (Fiscal Year 2004)
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| Budget Amount *help |
¥3,600,000 (Direct Cost: ¥3,600,000)
Fiscal Year 2004: ¥1,200,000 (Direct Cost: ¥1,200,000)
Fiscal Year 2003: ¥2,400,000 (Direct Cost: ¥2,400,000)
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| Keywords | ontogeny / hematopoietic / macrophages / hemangioblasts / yolk sac / placenta / 血管芽細胞 / 血管増殖因子 |
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| Research Abstract |
In this research, we try to clarify the in vivo ontogeny of the hematopoietic cells or blood vessels from hemangioblasts in the early stages of human placenta and yolk sac. About 20days of gestation, blood vessels appeared in the mesenchymal layer and started intravascular hematopoiesis. However, before the blood vesseles appeared in the yolk sac, macrophages presents in the mesenchimal layer, and villous vessels and macrophages were well developed in the placenta.
We observed that the placenta took lead in the hematopoiesis and vascular developement of the yolk sac, and trophoblastic Langhans layer in the early stage of the placenta might be play important roles.
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