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STUDY OF HUMAN PLACENTAL HEMATOPOIESIS

Research Project

Project/Area Number 15590333
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Experimental pathology
Research InstitutionNiigata University

Principal Investigator

HASEGAWA Go  Niigata University, Graduate School of Medical and Dental Sciences, Lecturer, 大学院・医歯学総合研究科, 講師 (90251800)

Co-Investigator(Kenkyū-buntansha) NAITO Makoto  Niigata University, Graduate School of Medical and Dental Sciences, Professor, 大学院・医歯学総合研究科, 教授 (30045786)
YAMAMOTO Takashi  Niigata University, Graduate School of Medical and Dental Sciences, Assistant, 大学院・医歯学総合研究科, 助手 (70313517)
Project Period (FY) 2003 – 2004
Project Status Completed (Fiscal Year 2004)
Budget Amount *help
¥3,600,000 (Direct Cost: ¥3,600,000)
Fiscal Year 2004: ¥1,200,000 (Direct Cost: ¥1,200,000)
Fiscal Year 2003: ¥2,400,000 (Direct Cost: ¥2,400,000)
Keywordsontogeny / hematopoietic / macrophages / hemangioblasts / yolk sac / placenta / 血管芽細胞 / 血管増殖因子
Research Abstract

In this research, we try to clarify the in vivo ontogeny of the hematopoietic cells or blood vessels from hemangioblasts in the early stages of human placenta and yolk sac. About 20days of gestation, blood vessels appeared in the mesenchymal layer and started intravascular hematopoiesis. However, before the blood vesseles appeared in the yolk sac, macrophages presents in the mesenchimal layer, and villous vessels and macrophages were well developed in the placenta.
We observed that the placenta took lead in the hematopoiesis and vascular developement of the yolk sac, and trophoblastic Langhans layer in the early stage of the placenta might be play important roles.

Report

(3 results)
  • 2004 Annual Research Report   Final Research Report Summary
  • 2003 Annual Research Report
  • Research Products

    (11 results)

All 2004 2003 Other

All Journal Article (9 results) Publications (2 results)

  • [Journal Article] Differentiation and function of Kupffer cells2004

    • Author(s)
      Naito M, G Hasegawa
    • Journal Title

      Med Electron Microsc 37

      Pages: 16-28

    • NAID

      10012836492

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Hepatocyte-specific Pten deficiency results in steatohepatitis and hepatocellular carcinomas2004

    • Author(s)
      Yasuo Horie, G Hasegawa, M Naito
    • Journal Title

      J CIin Invest 113

      Pages: 1774-1783

    • NAID

      120004837332

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Differentiation and function of Kupffer cells2004

    • Author(s)
      M.Naito
    • Journal Title

      Med Eletoron Microsc Vol.37

      Pages: 16-28

    • NAID

      10012836492

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Hepatocyte-specific Pten deficiency results in steatohepatitis and hepatocellular carcinomas2004

    • Author(s)
      Y.Horie
    • Journal Title

      J Clin Invest Vol.113

      Pages: 1774-1783

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Differentiation and function of Kupffer cells2004

    • Author(s)
      Naito M, G Hasegawa
    • Journal Title

      Med Electoron Microsc 37・1

      Pages: 16-28

    • NAID

      10012836492

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Hepatocyte-specific Pten deficiency results in steatohepatitis and hepatocellular carcinomas2004

    • Author(s)
      Yasuo Horie, G Hasegawa, M Naito
    • Journal Title

      J Clin Invest 113・12

      Pages: 1774-1783

    • NAID

      120004837332

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Expression of heme oxygenase-1 in rat ontogeny2003

    • Author(s)
      T Watanabe, G Hasegawa, M Naito
    • Journal Title

      Arch Histol Cytol 66

      Pages: 155-162

    • NAID

      10011992787

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Expression of heme oxygenase-1 in rat ontogeny2003

    • Author(s)
      T.Watanabe
    • Journal Title

      Arch Histol Cytol Vol.66

      Pages: 155-162

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Expression of heme oxygenase-1 in rat ontogeny2003

    • Author(s)
      T Watanabe, G Hasegawa, M Naito
    • Journal Title

      Arch Histol Cytol 66・2

      Pages: 155-162

    • NAID

      10011992787

    • Related Report
      2004 Annual Research Report
  • [Publications] Watanabe T: "Expression of heme oxygenase-1 in rat ontogeny"Arch Histol Cytol. 66・2. 155-162 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Naito M: "Differentiation and function of kupffer cells"Med Electron Microsc. 37・1. 16-28 (2004)

    • Related Report
      2003 Annual Research Report

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Published: 2003-04-01   Modified: 2016-04-21  

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