• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Structural differentiation of Helicobacter pylori lipopolysaccharide between peptic diseases

Research Project

Project/Area Number 15590381
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Bacteriology (including Mycology)
Research InstitutionAkita University

Principal Investigator

AMANO Ken-ichi  Akita University, Bioscience Education-Research Center, Associate Professor, バイオサイエンス教育・研究センター, 助教授 (40113766)

Project Period (FY) 2003 – 2004
Project Status Completed (Fiscal Year 2004)
Budget Amount *help
¥3,500,000 (Direct Cost: ¥3,500,000)
Fiscal Year 2004: ¥1,700,000 (Direct Cost: ¥1,700,000)
Fiscal Year 2003: ¥1,800,000 (Direct Cost: ¥1,800,000)
KeywordsHelicobacter / pylori / Endotoxin / LPS / Lewis antigen / Chronic gastritis / Peptic ulcer / Gastric Cancer / ルイス抗原 / 消化性疾患
Research Abstract

Since H.pylori was discovered in 1982, this bacterium has been thought to be pathogenic organism of chronic gastritis, peptic ulcer and gastric cancer. In this project we have done the research as follows.
1.I collected the sera from H.pylori-positive patients and strains in Japan and Poland.
2.The reactivities of patient sera to H. pylori lipopolysaccharides (LPS) were classified to 2 groups, highly antigenic epitope (HAE) and weakly antigenic epitope (WAE) in Japan. HAE containing LPS is related to the chronic gastritis, while WAE containing LPS is related to the gastric cancer.
3.The O-polysaccharides of H.pylori LPS are mimicking with the human Lewis blood antigens.
4.I tried the structural differentiation between HAE and WAE, but since these differentiation may be very little, I could not find them, using mass spectrometry and gas chromatography. However, their differentiation is detected with H.pylori-positive human sera.

Report

(3 results)
  • 2004 Annual Research Report   Final Research Report Summary
  • 2003 Annual Research Report
  • Research Products

    (14 results)

All 2004 2003 Other

All Journal Article (10 results) Book (2 results) Publications (2 results)

  • [Journal Article] Helicobacter pylori感染によると思われる人疾患患者のLPSとの反応性2004

    • Author(s)
      天野憲一
    • Journal Title

      エンドトキシン研究 7

      Pages: 133-137

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] The reactivity of human sera with several diseases after infected with Helicobacter pylori.2004

    • Author(s)
      K.Amano
    • Journal Title

      Endotoxin Research(In Japanese)

      Pages: 133-137

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Helicobacter pylori感染によると思われるヒト疾患患者血清のLPSとの反応性2004

    • Author(s)
      天野憲一
    • Journal Title

      エンドトキシン研究 7

      Pages: 133-137

    • Related Report
      2004 Annual Research Report
  • [Journal Article] ヒト血液型Lewis抗原を介したヒトと細菌のクロストーク2003

    • Author(s)
      天野憲一
    • Journal Title

      化学と生物 41

      Pages: 641-643

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Structure, biological activities and antigenic properties of Helicobacter pylori lipopolysaccharides2003

    • Author(s)
      S.Yokota
    • Journal Title

      Recent Research of Development Microbiology 7

      Pages: 251-267

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Cross-talking between humans and Helicobacter pylori through human Lewis blood antigens.2003

    • Author(s)
      K.Amano
    • Journal Title

      Chemistry and Biology(in Japanese) 41

      Pages: 641-643

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Structures, biological activities and antigenic properties of Helicobacter pylori Lipopolysaccharides.2003

    • Author(s)
      S.Yokota, K.Amano, S.Chiba, N.Fujii
    • Journal Title

      Recent Res.Devel.Microbiology 7

      Pages: 251-263

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] The role of human Lewis blood antigens for the Helicobacter pylori infection2003

    • Author(s)
      K.Amano
    • Journal Title

      Helicobacter pylori(Ed.Japanese Helicobacter Society)(Publishing by Sindan-to-Chiryousha)(In Japanese)

      Pages: 65-69

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] ヒト血液型Lewis抗原を介したヒトと細菌のクロストーク2003

    • Author(s)
      天野憲一
    • Journal Title

      化学と生物 41・10

      Pages: 641-643

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Structure, biological activities and antigenic properties of Helicobacter pylori lipopolysaccharides2003

    • Author(s)
      S.Yokota
    • Journal Title

      Recent Res.Devel.Microbiol. 7

      Pages: 251-267

    • Related Report
      2004 Annual Research Report
  • [Book] ヘリコバクター・ピロリ(Helicobacter pylori)2003

    • Author(s)
      天野憲一(共著)
    • Total Pages
      206
    • Publisher
      診断と診療社
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Book] ヘリコバクター・ピロリ(Helicobacter pylori)2003

    • Author(s)
      天野憲一(共著)
    • Total Pages
      206
    • Publisher
      診断と治療社
    • Related Report
      2004 Annual Research Report
  • [Publications] 天野憲一: "ヒト血液型Lewis抗原を介したヒトとピロリ菌のクロストーク"化学と生物. 41巻10号. 641-643 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] S.Yokota: "Structures, biological activities and antigenic properties of Helicobacter pylori lipopolysaccharides"Recent Res.Devel.Microbiology. 7巻. 251-267 (2003)

    • Related Report
      2003 Annual Research Report

URL: 

Published: 2003-04-01   Modified: 2016-04-21  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi