| Project/Area Number |
15590475
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Applied pharmacology
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| Research Institution | Fukuoka University |
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Principal Investigator |
KAI Mamiko Fukuoka University, Faculty of Pharmaceutical Sciences, Assistant Professor, 薬学部, 助手 (50289550)
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| Co-Investigator(Kenkyū-buntansha) |
KATAOKA Yasufumi Fukuoka University, Faculty of Pharmaceutical Sciences, Professor, 薬学部, 教授 (70136513)
KAI Hisashi Kurume University, School of Medicine, Associate Professor, 医学部, 助教授 (60281531)
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| Project Period (FY) |
2003 – 2004
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| Project Status |
Completed (Fiscal Year 2004)
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| Budget Amount *help |
¥2,900,000 (Direct Cost: ¥2,900,000)
Fiscal Year 2004: ¥1,400,000 (Direct Cost: ¥1,400,000)
Fiscal Year 2003: ¥1,500,000 (Direct Cost: ¥1,500,000)
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| Keywords | Ca^<2+> channel antagonist / nifedipine / ovariectomy / hot flushes / menopause / tail skin temperature / soybean isoflavones / estradiol replacement |
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| Research Abstract |
Hot flushes are the most frequent symptoms in menopausal women. Flushing, vasodilation-related adverse effect associated with Ca^<2+> channel antagonist treatment, occurs more frequently in women than men. We investigated effect of ovariectomy on nifedipine-induced flushing in mice. Ovariectomy markedly increased the tail skin temperature, a parameter of skin flushing, induced by nifedipine at a dose showing no influence on blood pressure. This event was blocked by estradiol replacement. Estrogen withdrawal is, therefore, included in the risk factors for nifedipine-induced flushing and this risk is lessened by estrogen replacement.
Next, we investigated effect of soybean isoflavones (Soyaflavone HG) on nifedipine-induced flushing in ovariectomized mice. Ovariectomy markedly aggravated nifedipine-induced increase in tail skin temperature. Soyaflavone HG (10 mg/kg, p.o., once a day for 5 days) inhibited nifedipine-induced flushing in ovariectomized mice. The inhibitory effect of Soyaflavone HG was significantly reversed by an estrogen-receptor antagonist, ICI 182,780, suggesting that Soyaflavone HG prevents nifedipine-induced flushing partially through estrogen receptors. We presented the experimental evidence suggesting that soybean isoflavones including Soyaflavone HG have the benefits for menopausal hot flushes.
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