| Project/Area Number |
15590479
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Laboratory medicine
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| Research Institution | Gunma University |
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Principal Investigator |
KUWABARA Atsushi GUNMA UNIVERSITY, Faculty of Medicine, Research Associate, 医学部, 助手 (90323344)
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| Co-Investigator(Kenkyū-buntansha) |
MURAKAMI Masami GUNMA UNIVERSITY, Faculty of Medicine, Professor, 大学院・医学系研究科, 教授 (30241871)
OKAJIMA Fumikazu GUNMA UNIVERSITY, Institute for Molecular and Cellular Regulatin, Professor, 生体調節研究所, 教授 (30142748)
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| Project Period (FY) |
2003 – 2005
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| Project Status |
Completed (Fiscal Year 2005)
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| Budget Amount *help |
¥3,500,000 (Direct Cost: ¥3,500,000)
Fiscal Year 2005: ¥1,100,000 (Direct Cost: ¥1,100,000)
Fiscal Year 2004: ¥1,100,000 (Direct Cost: ¥1,100,000)
Fiscal Year 2003: ¥1,300,000 (Direct Cost: ¥1,300,000)
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| Keywords | sphinaosine 1-phosphate / HDL-cholesterol / Atherosclerosis / lipoprotein / 脂質代謝 / 甲状腺ホルモン / リポタンパク / LDLコレステロール |
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| Research Abstract |
We reported that extracellular sphingosine 1-phosphate (S1P) contributed to the anti-atherogenic action of high density lipoprotein (HDL) on endothelial and smooth muscle cells. We also reported the relationship of lipoprotein-associated S1Pconcentrations with cholesterol and apolipoprotein contents of lipoprotein.
・HDL-induced endothelial cell migration and survival may be mediated by the lipoprotein component S1P and the lipid receptors S1P_1 and S1P_3.
・S1P component in HDL is responsible for the inhibition of vascular smooth muscle cells (VSMC) migration through S1P_2 receptors.
・S1P in HDL was associated with lipoprotein containing apolipoprotein A-I (LpA-I) and LpA-I/LpA-II particles, and correlated with serum levels of HDL-C and apo A-I. LDL-S1P was correlated with serum levels of LDL-C and apo B. It may be useful to investigate whether or not the balance between the HDL-S1P and LDL-S1P concentration could be important in predicting the risk of coronary heart disease, similar to the balance between HDL-C and LDL-C levels.
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