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PATHOLOGY, PATHOPHYSIOLOGY, AND DIAGNOSIS OF HELICOBACTER HEILMANNII INFEDTION

Research Project

Project/Area Number 15590482
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Laboratory medicine
Research InstitutionSHINSHU UNIVERSITY

Principal Investigator

OTA Hiroyoshi  SHINSHU UNIVERSITY, BIOMEDICAL LABORATORY SCIENCES, PROFESSOR, 医学部, 教授 (50273107)

Co-Investigator(Kenkyū-buntansha) FUJITA Kiyotaka  SHINSHU UNIVERSITY, BIOMEDICAL LABORATORY SCIENCES, ASSOCIATE PROFESSOR, 医学部, 助教授 (90313866)
KAWAKAMI Yoshiyuki  SHINSHU UNIVERSITY, BIOMEDICAL LABORATORY SCIENCES, PROFESSOR, 医学部, 教授 (90283275)
SANO Kenji  SHINSHU UNIVERSITY, LABORALORY MEDICINE, ASISTANT PROFESSOR, 医学部, 講師 (50205994)
KATSUYAMA Tsutomu  SHINSHU UNIVERSITY, LABORALORY MEDICINE, PROFESSOR, 医学部, 教授 (90020809)
Project Period (FY) 2003 – 2004
Project Status Completed (Fiscal Year 2004)
Budget Amount *help
¥3,500,000 (Direct Cost: ¥3,500,000)
Fiscal Year 2004: ¥1,300,000 (Direct Cost: ¥1,300,000)
Fiscal Year 2003: ¥2,200,000 (Direct Cost: ¥2,200,000)
Keywordsgastritis / Helicobacter heilmannii / Helicobacter pylori / MALToma / MALToma / ヘリコバクター・ハイルマニー / 慢性胃炎 / 胃潰瘍 / 胃MALTリンパ腫 / 動物モデル
Research Abstract

Gastric biopsy materials of 4074 consecutive Japanese patients undergoing esophagogastroduodenoscopy were reviewed, along with those of 15 patients with Helicobacter heilmannii (H.heilmannii) infection (1, chronic gastritis ; four, mucosa-associated lymphoid tissue (MALT) lymphoma]. The prevalence of H.heilmannii was 0.1% in the consecutive series. In chronic gastritis, the gastric mucosa was endoscopically normal (13.3%), had erythema (33.3%), or had erosions (53.3%) ; histologically, it showed no epithelial change, mild mononuclear cell infiltration, and slight and focal neutrophil infiltration. H.heilmannll was positive with anti-H.pylori antibody, and was detected in the mucous gel layer and in foveolae. In contrast, the serum and urinary antibody tests for H.pylori infection produced negative results in patients with H.heilmannii infection, suggesting the presence of relatively specific antigens in H.heilmannii : Eradication of H.heilmannii resulted in remission of MALT lymphoma. … More H.heilmannii infection is uncommon in Japanese adults, but is associated with chronic gastritis and gastric MALT lymphoma. A Mongolian gerbil model exhibited a high incidence of gastric MALT lymphoma-like lesion by H.heilmannii, whereas a Mongolian gerbil model of H.pylori infection exhibited hyperplastic polyps and ulcers. In Mongolian gerbils with H.pylori infection, high levels of mucosal IL-1β mRNA were observed early in the infection, reaching maximum at 4 weeks and then rapidly declining. Mucosal IFN-γ mRNA also reached maximal levels at 4 weeks but remained high there after. Both IL-1β and IFN-γ mRNA levels were consistently higher in the pyloric mucosa than in the fundic mucosa. In contrast, IL-4, IL-6, and IL-10 mRNA levels peaked at 8 to 26 weeks and levels were similar in the pyloric mucosa and the fundic mucosa. IFN-γ mRNA levels were significantly higher in gerbils with ulcers than in those with hyperplastic polyps. The different outcomes (e.g., ulcers or hyperplastic polyps) might relate to imbalances among cytokines. In Mongolian gerbils, loss of the virD4 gene in H.pylori temporally retarded but did not abrogate gastric inflammation, and loss of the cage gene in H.pylori abolished gastric inflammation partially via reduced ability to colonize. Unknown factors related to the type IV secretion system other than CagA may influence gastric inflammation. Less

Report

(3 results)
  • 2004 Annual Research Report   Final Research Report Summary
  • 2003 Annual Research Report
  • Research Products

    (59 results)

All 2005 2004 2003 Other

All Journal Article (52 results) Book (5 results) Publications (2 results)

  • [Journal Article] Natural History of Gastric Mucosal Cytokine Expression in Helicobacter pylori Gastritis in Mongolian Gerbils.2005

    • Author(s)
      Yamaoka Y, Yamauchi K, Ota H, Sugiyama A, Ishizone S, Graham DY, Maruta F, Murakami M, Katsuyama T
    • Journal Title

      Infect Immun 73

      Pages: 2205-2212

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Annual Research Report 2004 Final Research Report Summary
  • [Journal Article] Helicobacter heilmannii infection : clinical, endoscopic and histopathological features in Japanese patients2005

    • Author(s)
      Okiyama Y, Matsuzawa K, Hidaka E, Sano K, Akamatsu T, Ota H
    • Journal Title

      Pathol Int 55

      Pages: 398-404

    • NAID

      10019345023

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Roles of virD4 and cagG in the cag pathogenicity island of Helicobacter pylori in the gastric pathogenesis using a Mongolian gerbil model.2005

    • Author(s)
      Saito H, Yamaoka Y, Ishizone S, Maruta H, Sugiyama A, Graham DY, Ota H, Katsuyama T, Miyagawa S
    • Journal Title

      Gut 54

      Pages: 584-590

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Helicobacter heilmannii infection : clinical, endoscopic and histopathological features in Japanese patients.2005

    • Author(s)
      Okiyama Y, Matsuzawa K, Hidaka E, Sano K, Akamatsu T, Ota H
    • Journal Title

      Pathol Int 55

      Pages: 398-404

    • NAID

      10019345023

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Helicobacter heilmannii infection : clinical, endoscopic and histopathological features in Japanese patients2005

    • Author(s)
      Okiyama Y, Matsuzawa K, Hidaka E, Sano K, Akamatsu T, Ota H
    • Journal Title

      Pathol Int (in press)

    • NAID

      10019345023

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Roles of virD4 and cagG in the cag pathogenicity island of Helicobacter pylori in the gastric pathogenesis using a Mongolian gerbil model.2005

    • Author(s)
      Saito H, Yamaoka Y, Ishizone S, Maruta H, Sugiyama A, Graham DY, Ota H, Katsuyama T, Miyagawa S
    • Journal Title

      Gut (in press)

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Discrimination of Normal Gastric Mucosa from Helicobacter pylori Gastritis using Standard Endoscopes and a Single Observation Site : Studies in Children and Young Adults2004

    • Author(s)
      Nakayama Y, Horiuchi A, Kumagai T, Kubota S, Kobayashi M, Sano K, Ota H
    • Journal Title

      HELICOBACTER 9

      Pages: 95-99

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Annual Research Report 2004 Final Research Report Summary
  • [Journal Article] Histochemical, ultrastructural, and three-dimensional observation of smooth muscle cells in human gastric mucosa.2004

    • Author(s)
      Arai K, Ota H, Hidaka E, Hayama M, Sano K, Sugiyama A, Akamatsu T, Katsuyama T
    • Journal Title

      Histochem Cell Biol 121

      Pages: 229-237

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Annual Research Report 2004 Final Research Report Summary
  • [Journal Article] The Adherent Gastric Mucous Layer Is Composed of Alternating Layers of MUC5AC and MU C6 Mucin Proteins2004

    • Author(s)
      Ho SB, Takamura K, Anway R, Shekels LL, Toribara NW, Ota H
    • Journal Title

      Dig Dis Sci 49

      Pages: 1598-1606

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Eradication of Helicobacter pylori decreases mucosal alterations linked to gastric carcinogenesis in Mongolian gerbils.2004

    • Author(s)
      Maruta F, Sugiyama A, Ishizone S, Miyagawa S, Ota H, Katsuyama T
    • Journal Title

      J Gastroenterol 40

      Pages: 104-105

    • NAID

      10014371385

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Annual Research Report 2004 Final Research Report Summary
  • [Journal Article] Malignant granular cell tumor of the esophagus2004

    • Author(s)
      Yoshizawa A, Ota H, Sakaguchi N, Kanai S, Nakayama J, Matsuzawa K, Tsuzuki S, Takada R, Miyazawa F, Kasahara H, Katsuyama T
    • Journal Title

      Virchows Arch 444

      Pages: 304-306

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Annual Research Report 2004 Final Research Report Summary
  • [Journal Article] Degradation of pre-beta-high density lipoproteins and their binding activity to human blood monocytes.2004

    • Author(s)
      Nakabayashi T, Yamauchi K, Sugano M, Sano K, Tozuka M, Hidaka H.
    • Journal Title

      Ann Clin Lab Sci 34

      Pages: 287-298

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Annual Research Report 2004 Final Research Report Summary
  • [Journal Article] Comparison of thrombin-catalyzed fibrin polymerization and factor XIIIa-catalyzed cross-linking of fibrin among three recombinant variant fibrinogens, gamma 275C, gamma 275H, and gamma 275A2004

    • Author(s)
      Hirota-Kawadobora M, Terasawa F, Suzuki T
    • Journal Title

      J Thromb Haemost 2

      Pages: 1359-1367

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Annual Research Report 2004 Final Research Report Summary
  • [Journal Article] Autoimmune pancreatitis is closely associated with gastric ulcer presenting with abundant IgG4-bearing plasma cell infiltration2004

    • Author(s)
      Shinji A, Sano K, Hamano H, Unno H, Fukushima M, Nakamura N, Akamatsu T, Kawa S, Kiyosawa K.
    • Journal Title

      Gastrointest Endosc 59

      Pages: 506-511

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Lactate dehydrogenase (LD) extra isoenzyme electrophoretic band between LD1 and LD2 caused by a complex with a-lipoprotein2004

    • Author(s)
      Ishikawa J, Fujita K, Kanno T, Maekawa M
    • Journal Title

      Clin Chem Lab Med 42

      Pages: 102-104

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Annual Research Report 2004 Final Research Report Summary
  • [Journal Article] Natural antibiotic function of a human gastric mucin against Helicobacter pylori infection2004

    • Author(s)
      Kawakubo M, Ito Y, Okimura Y, Kobayashi M, Sakura K, Kasama S, Fukuda M N, Fukuda M, Katsuyama T, Nakayama J
    • Journal Title

      Science 305

      Pages: 1003-1006

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Annual Research Report 2004 Final Research Report Summary
  • [Journal Article] 受容体型プロテインチロシンホスファターゼζ(Ptprz)遺伝子欠損マウスはHelicobactor pyloriのVacAによる胃潰瘍形成に抵抗性である2004

    • Author(s)
      藤川顕寛, 白坂大輔, 山元勝一, 太田浩良, 八尋錦之助, 深田斉秀, 新谷隆史, 和田昭裕, 青山伸郎, 平山壽哉, 深町博史, 野田昌
    • Journal Title

      日本ヘリコバクター学会誌 5

      Pages: 5-8

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] H.pylori感染診断法 抗体測定法(血清,尿)2004

    • Author(s)
      熊谷俊子, 久保田聖子, 太田浩良
    • Journal Title

      Medical Technology メディカル・テクノロジー 32

      Pages: 786-790

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Annual Research Report 2004 Final Research Report Summary
  • [Journal Article] H.pylori感染診断法 便中抗原検査法2004

    • Author(s)
      熊谷俊子, 久保田聖子, 太田浩良
    • Journal Title

      Medical Technology メディカル・テクノロジー 32

      Pages: 791-795

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Annual Research Report 2004 Final Research Report Summary
  • [Journal Article] H.pylori感染診断法 培養法2004

    • Author(s)
      川上由行, 小穴こず枝, 太田浩良, 沖村幸枝, 岡部忠志, 山口 勝, 赤羽貴行
    • Journal Title

      Medical Technology メディカル・テクノロジー 32

      Pages: 801-807

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Annual Research Report 2004 Final Research Report Summary
  • [Journal Article] H.pylori感染診断法 鏡検法・病理組織学的検査法2004

    • Author(s)
      羽山正義, 太田浩良
    • Journal Title

      Medical Technology メディカル・テクノロジー 32

      Pages: 808-812

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Annual Research Report 2004 Final Research Report Summary
  • [Journal Article] Discrimination of Normal Gastric Mucosa from Helicobacter pylori Gastritis using Standard Endoscopes and a Single Observation Site Studies in Children and Young Adults.2004

    • Author(s)
      Nakayama Y, Horiuchi A, Kumagai T, Kubota S, Kobayashi M, Sano K, Ota H
    • Journal Title

      HELICOBACTER 9

      Pages: 95-99

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] The Adherent Gastric Mucous Layer Is Composed of Alternating Layers of MUCSAC and MUC6 Mucin Proteins.2004

    • Author(s)
      Ho SB, Takamura K, Anway R, Shekels LL, Toribara NW, Ota H
    • Journal Title

      Dig Dis Sci 49

      Pages: 1598-1606

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Malignant granular cell tumor of the esophagus.2004

    • Author(s)
      Yoshizawa A, Ota H, Sakaguchi N, Kanai S, Nakayama J, Matsuzawa K, Tsuzuki S, Takada R, Miyazawa F, Kasahara H, Katsuyama T
    • Journal Title

      Virchows Arch 444

      Pages: 304-306

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Degradation of pre-beta-high density lipoproteins and their binding activity to human blood monocytes.2004

    • Author(s)
      Nakabayashi T, Yamauchi K, Sugano M, Sano K, Tozuka M, Hidaka H
    • Journal Title

      Ann Clin Lab Sci 34

      Pages: 287-298

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Comparison of thrombin-catalyzed fibrin polymerization and factor XIIIa-catalyzed cross-linking of fibrin among three recombinant variant fibrinogens, gamma 275C, gamma 275H, and gamma 275A.2004

    • Author(s)
      Hirota-Kawadobora M, Terasawa F, Suzuki T, Tozuka M, Sano K, Okumura N
    • Journal Title

      J Thromb Haemost 2

      Pages: 1359-1367

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Autoimmune pancreatitis is closely associated with gastric ulcer presenting with abundant IgG4-bearing plasma cell infiltration.2004

    • Author(s)
      Shinji A, Sano K, Hamano H, Unno H, Fukushima M, Nakamura N, Akamatsu T, Kawa S, Kiyosawa K
    • Journal Title

      Gastrointest Endosc 59

      Pages: 506-511

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Lactate dehydrogenase (LD) extra isoenzyme electrophoretic band between LD1 and LD2 caused by a complex with a-lipoprotein.2004

    • Author(s)
      Ishikawa J, Fujita K, Kanno T, Maekawa M
    • Journal Title

      Clin Chem Lab Med 42

      Pages: 102-104

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Natural antibiotic function of a human gastric mucin against Helicobacter pylori infection.2004

    • Author(s)
      Kawakubo M, Ito Y, Okimura Y, Kobayashi M, Sakura K, Kasama S, Fukuda M N, Fukuda M, Katsuyama T, Nakayama J
    • Journal Title

      Science 305

      Pages: 1003-1006

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] The Adherent Gastric Mucous Layer Is Composed of Altemating Layers of MUC5AC and MUC6 Mucin Proteins2004

    • Author(s)
      Ho SB, Takamura K, Anway R, Shekels LL, Toribara NW, Ota H
    • Journal Title

      Dig Dis Sci 49

      Pages: 1598-1606

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Autoimmune pancreatitis is closely associated with gastric ulcer presenting with abundant IgG4-bearing plasma cell infiltration2004

    • Author(s)
      Shinji A, Sano K, Hamano H, Unno H, Fukushima M, Nakamura N, Akamatsu T, Kawa S, Kiyosawa K
    • Journal Title

      Gastrointest Endosc 59

      Pages: 506-511

    • Related Report
      2004 Annual Research Report
  • [Journal Article] 受容体型プロティンチロシンホスファターゼξ(Ptprz)遺伝子欠損マウスはHelicobacter pyloriのVacAによる胃潰瘍形成に抵抗性である2004

    • Author(s)
      藤川顕寛, 白坂大輔, 山元勝一, 太田浩良, 八尋錦之助, 深田斉秀, 新谷隆史, 和田昭裕, 青山伸郎, 平山壽哉, 深町博史, 野田昌
    • Journal Title

      日本ヘリコバクター学会誌 5

      Pages: 5-8

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Mice deficient in protein tyrosine phosphatase receptor type Z are resistant to gastric ulcer induction by VacA of Helicobacter pylori2003

    • Author(s)
      Fujikawa A, Shirasaka D, Yamamoto S, H Ota, Yahiro K, Fukada M, Shintani T, Wada A, Aoyama N, Hirayama T, Fukamachi H, Noda M
    • Journal Title

      Nature Genetics 33

      Pages: 375-381

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Usefulness of the real-time reverse transcription-polymerase chain reaction assay targeted to alpha1,4-N-acetylglucosaminyltransferase for the detection of gastric cancer2003

    • Author(s)
      Shimizu F, Nakayama J, Ishizone S, Zhang MX, Kawakubo M, Ota H, Sugiyama A, Kawasaki S, Fukuda M, Katsuyama T
    • Journal Title

      Lab Invest 83

      Pages: 187-197

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Duodenogastric reflux and Helicobacter pylori infection synergistically increase gastric mucosal cell proliferative activity in Mongolian gerbils2003

    • Author(s)
      Murakami M, Sugiyama A, Ota H, Maruta F, Ikeno T, Hayama M, Kumagai T, Okimura Y, Kawasaki S
    • Journal Title

      Scand J Gastroenterol 38

      Pages: 370-379

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Seroepidemiology of Helicobacter pylori and hepatitis A virus and the mode of transmission of infection : a 9-year cohort study in rural Japan2003

    • Author(s)
      Malaty HM, Tanaka E, Kumagai T, Ota H, Kiyosawa K, Graham DY, Katsuyama T
    • Journal Title

      Clin Infect Dis 37

      Pages: 1067-1072

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Expression of gastric gland mucous cell-type mucin in normal and neoplastic human tissues2003

    • Author(s)
      Nakajima K, Ota H, Zhang MX, Sano K, Honda T, Ishii K, Nakayama J
    • Journal Title

      J Histochem Cytochem 51

      Pages: 1689-1698

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Helicobacter pylori Infection Up-regulates Gland Mucous Cell-Type Mucins in Gastric Pyloric Mucosa2003

    • Author(s)
      Matsuzawa M, Ota H, Hayama M, Zhang MX, Sano K, Honda T, Ueno I, Akamatsu T, Nakayama J
    • Journal Title

      Helicobacter 8

      Pages: 594-600

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Implantation-dependent expression of trophinin by maternal Fallopian tube epithelia during tuba pregnancies : Possible role of human chorionic gonadotrophin on ectopic pregnancy2003

    • Author(s)
      Nakayama J, Aoki D, Suga T, Akama TO, Ishizone S, Yamaguchi H, Imakawa K, Nadano D, Fazleabas AT, Katsuyama T, Nozawa S, Fukuda M N
    • Journal Title

      Am J Pathol 163

      Pages: 2211-2219

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Myelination of a fetus with Pelizaeus-Merzbacher disease : immunopathological study2003

    • Author(s)
      Shiraishi K, Itoh M, Sano K, Takashima S, Kubota T
    • Journal Title

      Ann Neurol 54

      Pages: 259-562

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] フルクトサミン測定に影響を及ぼすIgA型M蛋白2003

    • Author(s)
      藤田清貴
    • Journal Title

      臨床検査 47

      Pages: 1068-1068

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] 抗イディオタイプ抗体によりLD結合能が阻害されないIgG1型M蛋白2003

    • Author(s)
      藤田清貴
    • Journal Title

      臨床検査 47

      Pages: 1478-1478

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] LDと結合するBence Jones蛋白の構造解析とその結合メカニズム2003

    • Author(s)
      藤田清貴
    • Journal Title

      臨床検査 47

      Pages: 1598-1598

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Helicobacter pyloriの薬剤感受性試験法の標準化とクラリスロマイシンに対する耐性機構研究の新しい展開2003

    • Author(s)
      川上由行
    • Journal Title

      信州医学雑誌 51

      Pages: 479-480

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Mice deficient in protein tyrosine phosphatase receptor type Z are resistant to gastric ulcer induction by VacA of Helicobacter pylori.2003

    • Author(s)
      Fujikawa A, Shirasaka D, Yamamoto S, H Ota, Yahiro K, Fukada M, Shintani T, Wada A, Aoyama N, Hirayama T, Fukamachi H, Noda M
    • Journal Title

      Nature Genetics 33

      Pages: 375-381

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Usefulness of the real-time reverse transcription-polymerase chain reaction assay targeted to alpha1,4-N-acetylglucosaminyltransferase for the detection of gastric cancer.2003

    • Author(s)
      Shimizu F, Nakayama J, Ishizone S, Zhang MX, Kawakubo M, Ota H, Sugiyama A, Kawasaki S, Fukuda M, Katsuyama T
    • Journal Title

      Lab Invest 83

      Pages: 187-197

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Duodenogastric reflux and Helicobacter pylori infection synergistically increase gastric mucosal cell proliferative activity in Mongolian gerbils.2003

    • Author(s)
      Murakami M, Sugiyama A, Ota H, Maruta F, Ikeno T, Hayama M, Kumagai T, Okimura Y, Kawasaki S
    • Journal Title

      Scand J Gastroenterol 38

      Pages: 370-379

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Seroepidemiology of Helicobacter pylori and hepatitis A virus and the mode of transmission of infection : a 9-year cohort study in rural Japan.2003

    • Author(s)
      Malaty HM, Tanaka E, Kumagai T, Ota H, Kiyosawa K, Graham DY, Katsuyama T
    • Journal Title

      Clin Infect Dis 37

      Pages: 1067-1072

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Expression of gastric gland mucous cell-type mucin in normal and neoplastic human tissues.2003

    • Author(s)
      Nakajima K, Ota H, Zhang MX, Sano K, Honda T, Ishii K, Nakayama J
    • Journal Title

      J Histochem Cytochem 51

      Pages: 1689-1698

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Helicobacter pylori Infection Up-regulates Gland Mucous Cell-Type Mucins in Gastric Pyloric Mucosa.2003

    • Author(s)
      Matsuzawa M, Ota H, Hayama M, Zhang M X, Sano K, Honda T, Ueno I, Akamatsu T, Nakayama J
    • Journal Title

      Helicobacter 8

      Pages: 594-600

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Implantation-dependent expression of trophinin by maternal Fallopian tube epithelia during tubal pregnancies : Possible role of human chorionic gonadotrophin on ectopic pregnancy.2003

    • Author(s)
      Nakayama J, Aoki D, Suga T, Akama TO, Ishizone S, Yamaguchi H, Imakawa K, Nadano D, Fazleabas AT, Katsuyama T, Nozawa S, Fukuda M N
    • Journal Title

      Am J Pathol 163

      Pages: 2211-2219

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Myelination of a fetus with Pelizaeus-Merzbacher disease : immunopathological study.2003

    • Author(s)
      Shiraishi K, Itoh M, Sano K, Takashima S, Kubota T
    • Journal Title

      Ann Neural 54

      Pages: 259-562

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Book] 胃炎のメカニズム 21世紀の胃の炎症学2005

    • Author(s)
      太田浩良, 吉澤明彦, 佐野健二
    • Total Pages
      373
    • Publisher
      メディカルレビュー社、東京
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Annual Research Report 2004 Final Research Report Summary
  • [Book] 胃粘液バリアー2005

    • Author(s)
      太田浩良(共同執筆)
    • Total Pages
      123
    • Publisher
      メディカルレビュー社、東京
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Annual Research Report 2004 Final Research Report Summary
  • [Book] 消化管の構造 看護のための最新医学講座(第2版) 第4巻 消化管疾患2005

    • Author(s)
      太田浩良, 中田りつ子
    • Total Pages
      494
    • Publisher
      中山書店、東京
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Annual Research Report 2004 Final Research Report Summary
  • [Book] IV 消化性潰瘍の病因 1.H.pylori(1)粘液との関わり 消化器病セミナー9 5消化性潰瘍-最新の治療2004

    • Author(s)
      太田浩良, 日高惠以子, 赤松泰次
    • Total Pages
      247
    • Publisher
      ヘルス出版,東京
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Book] IV 消化性潰瘍の病因 1.H.pylori (1)粘液との関わり 消化器病セミナー95消化性潰瘍-最新の治療2004

    • Author(s)
      太田浩良, 日高惠以子, 赤松泰次
    • Total Pages
      247
    • Publisher
      ヘルス出版,東京
    • Related Report
      2004 Annual Research Report
  • [Publications] Nakajima K, Ota H, Zhang MX, Sano K, Honda T, Ishii K, Nakayama J: "Expression of gastric gland mucous cell-type mucin in normal and neoplastic human tissues"J Histochem Cytochem. 51. 1689-1698 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Matsuzwa M, Ota H, Hayama M, Zhang MX, Sano K, Honda T, Ueno I, Akamatsu T, Nakayama J: "(2003) Helicobacter pylori Infection Up-regulates Gland Mucous Cell-Type Mucins in Gastric Pyloric Mucosa"Helicobacter. 8. 594-600 (2003)

    • Related Report
      2003 Annual Research Report

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Published: 2003-04-01   Modified: 2016-04-21  

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