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Is the disturbed early phase insulin response prescribed by the genetical role?

Research Project

Project/Area Number 15590491
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Laboratory medicine
Research InstitutionThe University of Tokushima

Principal Investigator

MIZUNO Akira  The University of Tokushima, Medical and Dental Hospital, Instructor, 医学部・歯学部附属病院, 助手 (80219641)

Co-Investigator(Kenkyū-buntansha) NOMA Yoshihiko  The University of Tokushima, Medical and Dental Hospital, Assistant Professor, 医学部・歯学部附属病院, 講師 (10218349)
ARAI Hidekazu  The University of Tokushima, Graduate School Institute of Health Biosciences, Instructor, 大学院・ヘルスバイオサイエンス研究部, 助手 (60325256)
TSUKAGUCHI Hiroyasu  The University of Tokushima, Graduate School Institute of Health Biosciences, Instructor, 大学院・ヘルスバイオサイエンス研究部, 助手 (60335792)
Project Period (FY) 2003 – 2005
Project Status Completed (Fiscal Year 2005)
Budget Amount *help
¥3,600,000 (Direct Cost: ¥3,600,000)
Fiscal Year 2005: ¥900,000 (Direct Cost: ¥900,000)
Fiscal Year 2004: ¥1,100,000 (Direct Cost: ¥1,100,000)
Fiscal Year 2003: ¥1,600,000 (Direct Cost: ¥1,600,000)
KeywordsPortal glucose sensor / Clamp-CPR-OGL method / Early phase insulin response / Obese subject / Impaired glucose tolerance
Research Abstract

lesion but not in pancreas and cephalic lesion. Previous study would suggest that hindrance in early phase insulin response (EPIS) is strongly related to onset and worsen type 2 diabetes mellitus. Measurement of EPIS using Clamp-OGL-CPR method was underwent in over 70 patients with obese and impaired glucose tolerance, although it had been done in only 30 subjects without obesity and normal glucose tolerance. We analyzed the EIS during Clamp-OGL-CPR method in normal subject who were divided into two groups, one group with diabetic diathesis and the other group without that, after the measurement of insulinogenic index during 75g OGTT. The results suggested that responsiveness of EPIS correlated with insulinogenic index and the diathesis of type 2 DM did not relate to disturbance in EPIS. After these studies, we started genetic markers concerning hindrances in EPIS, which reported to be existing in intestine and portal vein. We evaluated the polymorphism of glucokinase (GK) gene, although no significant difference was not determined between the two groups. Now we have been searching the diadetic gene, which will be related to portal glucose sensor.

Report

(4 results)
  • 2005 Annual Research Report   Final Research Report Summary
  • 2004 Annual Research Report
  • 2003 Annual Research Report
  • Research Products

    (14 results)

All 2006 2004 2003 Other

All Journal Article (10 results) Book (2 results) Publications (2 results)

  • [Journal Article] インスリングラルギン・グリクラジド併用療法の検討2006

    • Author(s)
      水野 明
    • Journal Title

      Diabetes Frontier (印刷中)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Studies on the combination therapy of insulin glarugine and gliclazide.2006

    • Author(s)
      Akira Mizuno
    • Journal Title

      Diabetes Frontier (in press)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] インスリングラルギン・グリクラジド併用療法の検討2006

    • Author(s)
      水野 昭
    • Journal Title

      Diabetes Frontier (印刷中)

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Effect of anovel palatinose-based liquid balanced formula (MHN-01) on glucose and lipid metabolism in male sprague-dawley rats after short- and long- term ingestion.2004

    • Author(s)
      Hidekazu Arai
    • Journal Title

      Metabolism 53・8

      Pages: 977-983

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Effect of novel palatinose-based liquid balanced formula (MHN-01) on glucose and lipid metabolism in male splaque-dawley rats after short- and long-term ingestion.2004

    • Author(s)
      Hidekazu Arai
    • Journal Title

      Metabolism 53(8)

      Pages: 977-983

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Effect of a novel palatinose-based liquid balanced formula(MHN-01) on glucose and lipid metabolism in male Sprague-Dawley rats after short-and long-term ingestion.2004

    • Author(s)
      Arai H
    • Journal Title

      Metabolism 53・8

      Pages: 977-983

    • Related Report
      2004 Annual Research Report
  • [Journal Article] 新規流動食(MHN-01)および従来流動食(SBF)の食後血糖値およびインスリン分泌量の比較2003

    • Author(s)
      庄司 有里
    • Journal Title

      日本病態栄養学会誌 6・3

      Pages: 303-309

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] 耐糖能異常および肥満の改善効果が期待できる新規流動食(MHN-01)の開発2003

    • Author(s)
      新井 英一
    • Journal Title

      栄養評価と治療 20・6

      Pages: 87-89

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Effect of novel liquid balanced formula (MHN-01) and standard blanced formula (SBF) on postprandial plasma levels of glucose and insulin.2003

    • Author(s)
      Yuri Shoiji
    • Journal Title

      Japan Clincal Neutritin 6(3)

      Pages: 303-309

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Development of novel liquid balanced formula (MHN-01) possessing the ability to ameliorate glucose tolerance of obese subjects.2003

    • Author(s)
      Hidekazu Arai
    • Journal Title

      Lapanese Journal of Nutritional Assessment 20(6)

      Pages: 87-89

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Book] インスリン抵抗性2006

    • Author(s)
      門脇 孝
    • Publisher
      南光堂
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Book] インスリン抵抗性2006

    • Author(s)
      門脇 孝
    • Publisher
      南光堂(印刷中)
    • Related Report
      2005 Annual Research Report
  • [Publications] Arai E: "Effect of a novel palatinose-based liquid formula(MHN-01)on glucose and lipid metabolism in male Sprague-Dawley rats after short- and long- term ingestion"Metabolism. (In press).

    • Related Report
      2003 Annual Research Report
  • [Publications] Mizuno A: "Disturved early phase insulin secretion in prediabetic subjects"Diabetes(supple). (In press).

    • Related Report
      2003 Annual Research Report

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Published: 2003-04-01   Modified: 2016-04-21  

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